A5100368174- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neural dynamics and brain function
- Anesthesia and Sedative Agents
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Vagus Nerve Stimulation Research
- Acupuncture Treatment Research Studies
- Enhanced Recovery After Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Cerebrovascular and Carotid Artery Diseases
- Resilience and Mental Health
- Neurological Disease Mechanisms and Treatments
- Bipolar Disorder and Treatment
- Ultrasound and Cavitation Phenomena
- Veterinary Pharmacology and Anesthesia
- Ion channel regulation and function
- Infant Development and Preterm Care
- Drug Transport and Resistance Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal and fetal brain pathology
- Pharmacological Receptor Mechanisms and Effects
Center for Pain and the Brain
2025
Massachusetts General Hospital
2025
Chinese Institute for Brain Research
2024
Capital Medical University
2024
Huazhong University of Science and Technology
2018-2024
Kunming Medical University
2018-2024
First Affiliated Hospital of Kunming Medical University
2018-2024
Jiangsu Hengrui Medicine (China)
2024
Union Hospital
2018-2024
First Affiliated Hospital of Xi'an Jiaotong University
2022
Abstract What We Already Know about This Topic Article Tells Us That Is New Background Xenon is an elemental anesthetic with nine stable isotopes. Nuclear spin a quantum property which may differ among 131 (131Xe) has nuclear of 3/2, xenon 129 (129Xe) 1/2, and the other seven isotopes have no spin. study was aimed to explore effect on potency. Methods Eighty C57BL/6 male mice (7 weeks old) were randomly divided into four groups, 132 (132Xe), 134 (134Xe), 131Xe, 129Xe groups. Due xenon’s low...
Abstract Background The prognostic significance of the CRAFITY score ( CR P and AF in I mmuno T herap Y ) has been demonstrated hepatocellular carcinoma (HCC) patients receiving immunotherapy. purpose this study was to investigate utility predictive value HCC after transarterial chemoembolization (TACE) combination with tyrosine kinase inhibitors (TKIs) Materials methods Data from advanced treated TACE plus TKIs PD-1 inhibitor January 2019 June 2022 were collected analyzed retrospectively....
Microtubules (MTs) have been postulated as one of the molecular targets underlying loss consciousness induced by inhalational anesthetics. Microtubule-targeting chemotherapy drugs and opioids affect MT stability function. However, impact prolonged administration these on anesthetic potency anesthesia induction emergence times remain unelucidated. Epothilone D, paclitaxel, vinblastine or opioid morphine were administered alone for a period (> 2 weeks) to male CD1 mice their sensitivity...
Abstract Background To compare the outcomes of ultra-fast-track anesthesia (UFTA) and conventional in cardiac surgery for children with congenital heart disease (CHD) low birth weight. Methods One hundred ninety-four CHD children, aged 6 months to 2 years, weighting 5 10 kg, were selected this study. The 94 boys 100 girls American Society Anesthesiologists (ASA) physical status III IV randomly divided into two groups each consisting 97 patients, subjected surgery. For UFTA group, sevoflurane...
Several miRNAs have been recently suggested as potential therapeutic targets for anesthesia-related diseases. This study was carried out to explore the biological roles of miR-24 in isoflurane-treated rat hippocampal neurons. Isoflurane used induce neurotoxicity a model. Gain- and loss-of-function performed, size Ca 2+ permeability mitochondria, well cell proliferation apoptosis, levels oxidative-stress-related factors were measured both vivo vitro. Dual luciferase reporter gene assays...
Sevoflurane is widely used as an inhalational anesthetic in clinical practice. However, sevoflurane can cause cytotoxicity and induce learning capacity decline patients. A previous publication indicated that miR-204-5p might have a close relationship with sevoflurane-induced neurotoxicity. When exposed to sevoflurane, the expression of neonatal hippocampus rats was significantly increased. Hence, we aimed investigate role neurotoxicity using mouse hippocampal neuronal cell line (HT22).The...
Phosphorus-31 nuclear-spin entanglements within Ca9(PO4)6 molecules (Posner molecules) have been proposed to be central for neural processing. However, this has yet proven experimentally. Relatedly, increasing calcium ion concentration in the cerebrospinal fluid enhance consciousness by accelerating Posner molecules' creation. A dependence on isotope is also expected. Here we test these predictions experimentally measuring loss of righting reflex ED50 mice sevoflurane - an increase indicates...
It is widely accepted that the induction dose of anesthetics higher in infants than adults, although relevant molecular mechanism remains elusive. We previously showed neuronal hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to hypnotic actions propofol and ketamine. Interestingly, expression HCN neocortex significantly changes during postnatal periods. Thus, we postulated might sensitivity intravenous anesthetics. Here EC50 for propofol- ketamine-induced...
<title>Abstract</title> 【Background】 To dynamically monitor the plasma melatonin and cortisol levels in patients with bipolar depressive episodes, to improve polysomnography, analyze circadian rhythm characteristics of depression, we explore value disorders diagnosed depression.【Methods】A total 54 subjects were included, comprising 16 cases 12 unipolar 11 depression remission, 15 healthy controls. High-performance liquid chromatography-tandem mass spectrometry was used detect four groups at...
SHR-1707 is a novel humanized anti-Aβ IgG1 monoclonal antibody that binds to Aβ fibrils and monomers block the formation of plaques or promote microglial phagocytosis Aβ. Preclinical studies showed reduced brain deposition in 5xFAD transgenic mice. Herein, we conducted two phase 1 evaluate safety, tolerability, pharmacokinetics (PK) pharmacodynamics (PD) single intravenous dose healthy adult subjects.
OBJECTIVE To observe the effect of electroacupuncture (EA) pretreatment on hippocampal oxidative stress in aged mice with postoperative cognitive dysfunction (POCD) and explore relevant mechanism EA improvement learning memory POCD mice. METHODS A total 72 healthy male were randomized into a blank group, model medication group an 18 each one. In 1-day, 3-day 7-day subgroups divided separately, 6 subgroup. Baihui (GV 20) Dazhui 14) selected stimulated EA, using continuous wave (15 Hz, 1 mA),...
Purpose: To determine the apoptotic effect of sevoflurane on lung cancer cells, and underlying mechanism action.Methods: Lung adenocarcinoma A549 cells were cultured for 24 h divided into control group, 1% group 3% group. The two levels provided through a gas monitor connected to each groups. was not treated. Flow cytometry used analyze cell apoptosis, while qRT-PCR assay miRNA155 in cells. protein expression Bcl-2 determined with immunoblotting. percentage apoptosis lines compared.Results:...
Objective To investigate the effect and mechanism of low-dose remifentanil(RF)on systemic artery tension baby rabbit with septic shock.Methods Thirty-six strips were prepared from 12 rabbits randomly divided into 6 groups:control group,lipopoly-saccharide(LPS)group,RF group,LPS + RF group,NG-nitro-L-arginine(L-NNA)pretreated L-NNA pretreated group.Each group had six rings(n =6).The on shock was observed isolated vascular ring technique.The change also obversed after pretreatment.Results In...
Objective To evaluate the effect of isoflurane on expression hippocampal ubiquitin C-terminal hydrolase-L1(UCH-L1)mRNA in aged rats. Methods Thirty-six pathogen-free healthy male Sprague-Dawley rats, 20 months, weighing 500-700 g, were divided into 2 groups using a random number table: control group(group C, n=12)and I, n=24). In group 2% was continuously inhaled for h. Twelve rats selected at 24 and 72 h after stopping inhalation(T1, 2), Y-maze test performed to cognitive...
Objective Effect of fluoxetine on the expression angiogenic factors in hippocampus depressive rats. Methods 32 male SD rats (3 month) SPF level were randomly divided into group (n=8), + LY294002 intervention model (n=8) and control (n=8). Control without any treatment was free to eat water for 5 weeks.The other groups modeled by chronic, mild unpredictable multiphase stress.The treated with 2 weeks after modeling, given intervention, then weeks, drink weeks.At end 5th week, all...
Objective To evaluate the effect of electric stimulation vagus nerves on expression aquaporin-4 (AQP-4) in brain tissues rats with endotoxemia. Methods Forty-eight adult male Sprague-Dawley rats, aged 2 months, weighing 200-250 g, were divided into 4 groups (n=12 each) using a random number table: sham operation group (S group), endotoxemia (E nerve transection (VNT group) and plus (VNT+ VNS group). The model endoxemia was established by injection lipopolysaccharide 10 mg/kg via...
Objective To investigate whether the male adulthood brain volumes changes are correlated to their prenatal earthquake stress experience or suffering depression after birth. Methods A total of 956 adult males born in Tangshan during were visited, and finally 41 subjects recruited with 10 stress-depression group (experienced developed birth), 18 stress-health but no history mental disorders 13 blank control. 3.0 T magnetic resonance imaging was conducted on all record T1-weighted...
Objective To explore the effects of early psychological trauma and corticotropin-releasing factor receptor 1(CRHR1) gene polymorphism on working memory. Methods 1 534 healthy adult volunteers were recruited divided into 3 groups according to whether ever being exposed Tangshan earthquake in their life: infant exposure group (IEG, n=176), fetal (FEG, n=172), control (n=182). The was further three subgroups: first trimester (1~3months, n=50), second (4~6months, n=59), third (7~9months,...
Abstract It is believed that inhaled anesthetics occupy hydrophobic pockets within target proteins, but how with diverse shapes and sizes fit into highly structurally selective unknown. For hydroxide ions are hydrophobic, we determined whether could bridge protein pockets. We found small additional load of cerebral decreases anesthetic potency. Multiple-water entanglement network, derived from Ising model, has a great ability to amplify ultralow changes in the ion concentration,...