A5103213168- Vagus Nerve Stimulation Research
- Neuropeptides and Animal Physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Receptor Mechanisms and Effects
- Anesthesia and Neurotoxicity Research
- Spinal Cord Injury Research
- Pain Mechanisms and Treatments
- Patient Safety and Medication Errors
- Healthcare Technology and Patient Monitoring
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Pediatric Pain Management Techniques
Massachusetts General Hospital
2020-2025
Shriners Hospitals for Children - Erie
2020-2025
First Affiliated Hospital of Zhengzhou University
2017-2022
Shriners Hospitals for Children - Boston
2020-2022
Harvard University
2020-2022
University of Toronto
2020
Microtubules (MTs) have been postulated as one of the molecular targets underlying loss consciousness induced by inhalational anesthetics. Microtubule-targeting chemotherapy drugs and opioids affect MT stability function. However, impact prolonged administration these on anesthetic potency anesthesia induction emergence times remain unelucidated. Epothilone D, paclitaxel, vinblastine or opioid morphine were administered alone for a period (> 2 weeks) to male CD1 mice their sensitivity...
Background: Burn injury (BI) pain consists of inflammatory and neuropathic components activates microglia. Nicotinic alpha 7 acetylcholine receptors (α7AChRs) expressed in microglia exhibit immunomodulatory activity during agonist stimulation. Efficacy selective α7AChR GTS-21 to mitigate BI spinal pain-mediators was tested. METHODS: Anesthetized rats after hind-paw received intraperitoneal or saline daily. Allodynia hyperalgesia were tested on contralateral paw for 21 days. Another group...
Abstract Introduction Burn-induced systemic inflammation (BISI) can induce inflammatory responses in peripheral nervous system and also cause neuroinflammation the central system, leading to morbidity mortality. The mechanisms of neuromotor impairment involving CCL2/CCR2 signaling axis are largely unknown. We hypothesized that BISI causes spinal cord, this response lead motor neuronal damage, disintegration nerve termini eventually muscle wasting. Methods Cytokines/chemokines were estimated...