A5077013671- Protein Structure and Dynamics
- Nutrition and Health in Aging
- Machine Learning in Bioinformatics
- COVID-19 Clinical Research Studies
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 diagnosis using AI
- Long-Term Effects of COVID-19
- Frailty in Older Adults
- RNA and protein synthesis mechanisms
- Spectroscopy and Chemometric Analyses
- COVID-19 and healthcare impacts
- Text and Document Classification Technologies
- Hip and Femur Fractures
- Colorectal Cancer Surgical Treatments
- Aortic Disease and Treatment Approaches
- Algorithms and Data Compression
- Intracranial Aneurysms: Treatment and Complications
- Advanced Image and Video Retrieval Techniques
- Respiratory Support and Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Cavitation Phenomena in Pumps
- Cancer survivorship and care
- Optical Systems and Laser Technology
- Vascular Malformations Diagnosis and Treatment
The First Hospital of Changsha
2024
Huazhong University of Science and Technology
2020-2024
Union Hospital
2020-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2020-2024
Anhui University
2024
Union Hospital
2021-2024
Xidian University
2014-2016
Iowa State University
2005-2009
Abstract Background Understanding the molecular details of protein-DNA interactions is critical for deciphering mechanisms gene regulation. We present a machine learning approach identification amino acid residues involved in interactions. Results start with Naïve Bayes classifier trained to predict whether given residue DNA-binding based on its identity and identities sequence neighbors. The input consists target 4 neighbors each side residue. evaluated (using leave-one-out...
Abstract Background The body composition of patients with rectal cancer potentially affects postoperative outcomes. This study explored the correlations between skeletal muscle and adipose tissue quantified by computed tomography (CT) complications long‐term prognosis in after surgical resection. Methods retrospective cohort included who underwent resection at Wuhan Union Hospital 2014 2018. CT images within 3 months prior to surgery were used quantify indices levels third lumbar vertebra...
3D digital subtraction angiography (DSA) reconstruction from rotational 2D projection X-ray is an important basis for diagnosis and treatment of intracranial aneurysms (IAs). The gold standard requires approximately 133 different views reconstruction. A method to significantly reduce the radiation dosage while ensuring quality yet be developed. We propose a self-supervised learning realize 3D-DSA using ultra-sparse projections. 202 cases (100 one hospital training testing, 102 two other...
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Background and Objectives: To investigate whether coronavirus disease 2019 (COVID-19) survivors who had different severities have levels of pulmonary sequelae at 3 months post-discharge. Methods: COVID-19 patients discharged from four hospitals previously, recovered asymptomatic an isolation hotel, uninfected healthy controls (HCs) the community were prospectively recruited. Participants recruited Wuhan Union Hospital underwent examinations, including quality-of-life evaluation (St. George...
Abstract Objective To investigate the prognostic value of preoperative body composition and serum tumor markers (STM) in patients undergoing surgical treatment for colorectal cancer (CRC) to establish score with CRC. Methods This study enrolled 365 (training set 245, validation 120) CRC who underwent resection. The predictive various features STM determining prognosis were compared. A novel index based on independent risk factors from Cox regression was established evaluated its usefulness....
Abstract Background Chest computed tomography (CT) has been widely used to assess pulmonary involvement in COVID-19. We aimed investigate the correlation between chest CT and clinical features COVID-19 suspected patients with or without fever. Methods retrospectively enrolled 211 who underwent both reverse transcription polymerase chain reaction Wuhan, China. The performance of relevant onset symptoms, fever (n = 141) 70), was assessed respectively. Results sensitivity for 97.3%, area under...
Sarcopenia is a progressive generalized loss of skeletal muscle mass commonly observed in advanced stages cancer.To assess the relationship between sarcopenia and prognosis patients with hepatocellular carcinoma (HCC) treated programmed cell death 1 (PD-1) inhibitor.This retrospective study.This study included HCC camrelizumab March 2020 December 2021. The area at L3 vertebra middle level was used to calculate index. Propensity score matching (PSM) analysis balance variables two groups.In...
In order to improve the precision of visible and infrared (VIS/IR) image registration, an registration method based on visual salient (VS) features is presented. First, a VS feature detector modified attention model presented extract points. Because iterative, within-feature competition used in models time consuming, alternative fast (FVS) proposed make more efficient. Then, descriptor-rearranging (DR) strategy adopted describe This combines information both IR its negative overcome contrast...
The ability to identify protein binding sites and detect specific amino acid residues that contribute the specificity affinity of interactions has important implications for problems ranging from rational drug design analysis metabolic signal transduction networks. Support vector machines (SVM) related kernel methods offer an attractive approach predicting sites. An appropriate choice function is critical performance SVM. Kernel functions a way incorporate domain-specific knowledge into...
In this study, our focus was on pulmonary sequelae of coronavirus disease 2019 (COVID-19). We aimed to develop and validate CT-based radiomic models for predicting the presence residual lung lesions in COVID-19 survivors at three months after discharge.We retrospectively enrolled 162 confirmed patients hospital (84 with 78 without lesions, discharge). The were all randomly allocated a training set (n = 114) or test 48). Radiomic features extracted from chest CT images different regions...
To provide the quantitative volumetric data of total lung and lobes in inspiration expiration from healthy adults, to explore value paired inspiratory-expiratory chest CT scan pulmonary ventilatory function further influence each lobe on ventilation.A 65 adults (29 males 36 females) with normal clinical test (PFT) were retrospectively enrolled. The inspiratory expiratory indexes (TL) 5 (left upper [LUL], left lower [LLL], right [RUL], middle [RML], [RLL]) obtained by Philips IntelliSpace...
As the electronic image stabilization (EIS) algorithm based on SIFT feature matching has problem of complex computation and time consuming, a modified EIS PCA-SIFT self-adaptive high-pass filtering is proposed in this paper. Firstly, points are extracted by using reference frame current frame. And corresponding matched between these two images. Then Random Sample Consensus (RANSAC) used to eliminate error pairs reduce influence local motion scene improve estimation accuracy global...
Abstract The pumped-storage power stations (PSPSs) with variable speed units (VSUs) have been emerging in recent years, and the research on transient processes of those PSPSs is great significance. In this paper, a PSPS four units, i.e. three fixed (FSUs) one VSU, sharing tunnel are numerically simulated under conditions large fluctuation small fluctuation. Firstly, combining calculation method hydraulic basic equations pump turbine, doubly-fed induction motor (DFIM) governor,...
Abstract Recently, the efficacy of two low-invasive treatments, ablation, and radiotherapy, has been fully compared for patients with early-stage hepatocellular carcinoma (HCC). However, comparison between radiotherapy plus ablation alone less frequently reported. Data from Surveillance, Epidemiology, End Results (SEER) database were searched HCC treated or alone. The outcome measures overall survival (OS) cancer-specific (CSS). propensity score matching (PSM) was used to reduce selection...
To explore the general clinical features and treatment outcomes of patients with AIDS-related diffuse large B-cell lymphoma (AIDS-DLBCL) provide a theoretical basis for diagnosis treatment, survival prognosis, prevention management AIDS-DLBCL patients. who received combined antiretroviral therapy (cART) at Changsha First Hospital from January 2017 to 2020 were selected in this study. The curves plotted using Kaplan-Meier method, Cox proportional hazards regression model was used analyze...