A5101901012- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Ovarian cancer diagnosis and treatment
- Clusterin in disease pathology
- Ubiquitin and proteasome pathways
- Adsorption and biosorption for pollutant removal
- Cytokine Signaling Pathways and Interactions
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects of Natural Compounds
- Chronic Lymphocytic Leukemia Research
- DNA and Biological Computing
- Multiple Myeloma Research and Treatments
- Gout, Hyperuricemia, Uric Acid
- RNA modifications and cancer
- Calpain Protease Function and Regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- Moyamoya disease diagnosis and treatment
- Estrogen and related hormone effects
- Clostridium difficile and Clostridium perfringens research
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
Jiangnan University
2024
Jiangsu University
2024
Hangzhou Dianzi University
2023
Peking University
2019-2023
Sun Yat-sen University
2015-2022
Wuxi People's Hospital
2019-2022
The Seventh Affiliated Hospital of Sun Yat-sen University
2022
Second Affiliated Hospital of Nanjing Medical University
2021
Chemical Synthesis Lab
2020
Genomics (United Kingdom)
2020
Induction of protein degradation is emerging as a powerful strategy to modulate functions and alter cellular signaling pathways. Proteolysis-targeting chimeras (PROTACs) have been used degrade range diverse proteins in vitro vivo. Here we present type photo-caged PROTACs (pc-PROTACs) induce activity with light. Photo-removable blocking groups were added degrader Brd4, the resulting molecule pc-PROTAC1 showed potent live cells only after light irradiation. Furthermore, this efficiently...
Covalent inhibitor-based PROTACs were successfully developed for the degradation of target proteins in live cells to further extend application scope PROTACs.
Neuropathic pain is a serious clinical problem that needs to be solved urgently. ASK1 an upstream protein of p38 and JNK which plays important roles in neuroinflammation during the induction maintenance chronic pain. Therefore, inhibition may novel therapeutic approach for neuropathic Here, we aim investigate effects paeoniflorin on The mechanical thermal thresholds rats were measured using Von Frey test. Cell signaling was assayed western blotting immunohistochemistry. Chronic constrictive...
The pathogenesis of cerebral ischemia-reperfusion (I/R) is complex. Cx32 expression has been reported to be up-regulated in ischemic lesions aged human brain. Nevertheless, the function during I/R poorly understood. Autophagy vital importance I/R. In current study, we found that oxygen-glucose deprivation/reoxygenation (OGD/R) or insult significantly induced up-regulation and activation autophagy. Inhibition alleviated OGD/R injury, further activated addition, Nur77 was after After...
Interleukin-2-inducible T-cell kinase (ITK) is a promising therapeutic target for human autoimmune diseases and malignant lymphomas. This paper reports the development of series cereblon-recruiting ITK proteolysis targeting chimeras based on structure-based design strategy. The representative compounds 23 28 exhibited potent degradation IL-2 inhibition activities in Jurkat cells. Global proteomic profiling assays indicated that are highly selective degraders. Moreover, compound showed good...
A data backtracking operation was successfully realized by adding redundant modules to the circuit, greatly improving system reliability.
The objective of the present study is to determine role prostaglandin E2 (PGE2) and downstream EP receptors in development human papillary thyroid carcinoma (PTC). A total 90 specimens excised from patients undergoing or subtotal thyroidectomy Department General Surgery, Fifth Affiliated Hospital Sun Yat-sen University, China, August 2013 September 2014, were analyzed. quantitative reverse transcription–polymerase chain reaction (qRT-PCR) immunohistochemical analyses employed examine...
17a-Hydroxylase/17,20-lyase deficiency (17OHD) is caused by pathogenic mutations in CYP17A1. Female patients present with hypertension, hypokalemia, and sexual infantilism while males sex development disorder. Moyamoya disease (MMD) a chronic cerebrovascular that frequently results intracranial ischemia or hemorrhage. The study describes case of 17OHD MMD 27-year-old phenotypically female (46, XY) patient discusses the clinical features characteristics her genetic defect. Clinical, hormonal,...
Abstract Background: To analyse the value of C-reactive protein (CRP) kinetics and initial apolipoproteinA1 (apoA-I) level as prognostic parameters in advanced non-small Cell Lung Cancer (NSCLC). Methods : Within a retrospective single-center study, serum CRP apoA-I were measured at baseline start each platinum-based chemotherapy cycle for 125 NSCLC patients. Survival analysis, calculated by Kaplan–Meier method log-rank test, was used to assess significance Serum both levels. The...
Abstract Background: To analyse the value of C-reactive protein (CRP) kinetics and initial apolipoproteinA1 (apoA-I) level as prognostic parameters in advanced non-small Cell Lung Cancer (NSCLC). Methods : Within a retrospective single-center study, serum CRP apoA-I were measured at baseline start each platinum-based chemotherapy cycle for 125 NSCLC patients. Survival analysis, calculated by Kaplan–Meier method log-rank test, was used to assess significance Serum both levels. The...
Objective To evaluate Chinese long-term economic impact of universal human leukocyte antigen B (HLA-B)*58:01 genotyping-guided urate-lowering therapy or febuxostat initiation for gout patients with mild to moderate chronic kidney disease (CKD) from perspective healthcare system. Methods A Markov model embedded in a decision tree was structured including four mutually exclusive health states (uncontrolled-on-therapy, controlled-on-therapy, uncontrolled-off-therapy, and death). Mainly based on...
Abstract Purpose : This study was to evaluate the value of C-reactive protein (CRP) kinetics and initial apolipoproteinA1 (apoA-I) level as prognostic parameters in advanced non-small Cell Lung Cancer (NSCLC). Methods: Within a retrospective single-center study, serum CRP apoA-I were measured at baseline start each platinum-based chemotherapy cycle for 125 NSCLC patients. Survival analysis, calculated by Kaplan–Meier method log-rank test, used assess significance Serum both levels. The...