A5100372517- Crystallization and Solubility Studies
- Advanced Fiber Optic Sensors
- X-ray Diffraction in Crystallography
- Zeolite Catalysis and Synthesis
- Chemical and Physical Properties in Aqueous Solutions
- Analytical Chemistry and Chromatography
- Mesoporous Materials and Catalysis
- Optical Coherence Tomography Applications
- Photonic and Optical Devices
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Phase Equilibria and Thermodynamics
- Advanced Fiber Laser Technologies
- Polyoxometalates: Synthesis and Applications
- Analytical Chemistry and Sensors
- Crystallography and molecular interactions
- Catalysis and Hydrodesulfurization Studies
- Computational Drug Discovery Methods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Characterization
- Neural Networks and Reservoir Computing
- Photonic Crystal and Fiber Optics
- Freezing and Crystallization Processes
- Optical Systems and Laser Technology
- Advanced Nanomaterials in Catalysis
Tianjin University
2014-2024
Purdue University West Lafayette
2020
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015-2020
State Key Laboratory of Chemical Engineering
2015-2020
Tianjin Institute of Pharmaceutical Research (China)
2020
Crystallization, as a solid–liquid separation process, is employed to purify and isolate great diversity of crystalline pharmaceutical products. In recent years, continuous crystallization has attracted increasing attention because the product process robustness well higher productivity. this work, we review use novel crystallizers or modified conventional for preparation polymorphs, chiral enantiomers, solvates/hydrates, cocrystals, spherical crystals. addition, theoretical framework...
Generally, 3,3',5,5'-tetramethylbenzidine (TMB) cannot react with hydrogen peroxide (H2O2) in neutral pH or water at room temperature and pressure. Herein, we found that hexavalent chromium (Cr6+) can trigger TMB reacting H2O2 (TMB-H2O2) ultrapure along a weak signal output. Then, to implement amplification effectively, designed ternary nanohybrid material containing graphene oxide (GO) nanosheets, gold nanoparticles (Au NPs), hyperbranched polyethylenimine (PEI) form rGO/PEI/Au nanohybrids...
Compensating the temperature dependency and slight nonlinearity of magneto-optic response a fiber optic current sensor (FOCS) are crucial to improve its accuracy. In this article, originations FOCS with static-biasing scheme for compensation analyzed characterized. We found that static bias varying magnetic domains Faraday crystal two main sources nonlinearity. A back-propagation neural network (BPNN) aided by whale optimization algorithm (WOA) is developed compensate nonlinear sensor....
The growth of thiamine nitrate, in supersaturated aqueous solutions the absence and presence sodium alkyl sulfates CH3(CH2)nSO4Na sulfonates CH3(CH2)nSO3Na was studied by a single seed crystal experiment. It surprisingly found that a-axis nitrate is significantly inhibited CH3(CH2)nSO4Na, thus reducing aspect ratio while remains almost constant. Furthermore, mechanism additives to modify morphology proposed: both can inhibit hindering solute diffusion. However, their unusual behavior due...
The solubility of benzoin in monosolvents (acetone, ethyl acetate, methanol, ethanol, 1-propanol, and 1-butanol) binary solvent mixtures (ethyl acetate + ethanol) was measured using UV–vis spectroscopy at temperatures ranging from 283.15 K to 323.15 K. It can be seen the data that increases expectedly as temperature a given or mixture, acetone is maximum among six which could well explained by existence strong H-bonds, rather than "like dissolves like" rule. In mixtures, reaches when mole...
At present, the reconstruction error of optical fiber shape sensing is commonly represented by Euclidean distance error. However, Euclidian will be dependent on complexity, which depends length, curvature and torsion. In this paper, we establish a model distributed in frequency domain reflectometry (OFDR) based Frenet-Serret frame delivering theory, illustrates relationship between parameters such as curvature, torsion, length strain measurement We experimentally verify feasibility...
A gravimetric method was used to determine the solubility of azoxystrobin in seven monosolvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, and ethyl acetate) two binary mixed solvents (n-propanol + acetate methanol at different temperatures from 288.15 328.15 K. The is positively related with temperature all selected solvents. Moreover, solvent reaches a maximum when mole fraction 0.8, differing that n-propanol solvent. Apelblat, λh, combined nearly ideal...
In this paper, fiber sensor based on Vernier effect for simultaneous measurement of relative humidity (RH) and temperature is proposed. The fabricated by coating two kinds ultraviolet (UV) glue with different refractive indexes (RI) thicknesses the end face a patch cord. films are controlled to generate effect. inner film formed cured lower-RI UV glue. exterior higher-RI glue, which thickness much thinner than film. Through analysis Fast Fourier Transform (FFT) reflective spectrum, polymer...
Reactive crystallization and polymorphic transformation of clopidogrel hydrogen sulfate (CHS) in nine pure solvents were studied at 313.15 K. It is found that thermodynamically stable form tends to be obtained with higher solubility CHS the conversion rates from I II are also mainly increased increasing solubility. The solvent bond donor ability essential for determining effects on formation CHS. Besides, reactive different supersaturations 2-propanol 2-butanol was monitored online by using...
In this article, we introduce an intensity demodulation method for the optical Vernier effect based on intelligent algorithm. To reduce requirement a large number of pre-collected raw spectra training three-layer neural network, spectrum interpolation scheme was incorporated. With proposed method, measurand can be demodulated by simply measuring relative at three wavelengths. A Vernier-effect temperature sensor consisting two parallel fiber Fabry–Perot interferometers (FPIs) fabricated and...
A gravimetric method was used to determine the solubility of maltitol in five pure solvents, methanol–water mixtures, and ethanol–water mixtures at different temperatures from 298.15 323.15 K. At a given temperature, solvents follows this order: 2-propanol < ethanol methanol DMF water. Compared with modified Van't Hoff equation, Apelblat equation presents better consistence solvents. The increases rising but decreases increase initial mole fraction or ethanol. It is found that can give...
In this work, an ethanol solvate of argatroban was first discovered and fully characterized. The ternary phase diagrams for ethanol–water–argatroban at 35.0, 40.0, 45.0 °C were established to determine the thermodynamic stability. situ Raman IR spectroscopy applied analysis solution-mediated transformation from monohydrate in ethanol–water solvent. It is evident that rate-controlling step growth initial stage dissolution later stage. To further understand control process, effects solvent...
Abstract Clopidogrel hydrogen sulfate is a famous antiplatelet agent for vascular disease. Forms I and II can be used as medicine. However, both forms exhibit low density flowability. In addition, form shows polymorph stability. To solve these problems, spherical crystallization technologies were developed the two forms. For I, mechanism was studied turned out to 2D nucleation spherulitic crystal growth. case of II, process based on agglomeration. The influence temperature, acid, seed...
We present a long distance distributed strain sensing in optical frequency domain reflectometry (OFDR) by shape-adaptive principal component analysis Block-Matching three-dimensional filter (BM3D-SAPCA) image denoising, which uses correlated patterns and high degree redundancy of data for enhancing the performance processing removing noise increasing signal-to-noise ratio (SNR) noisy measurements. Compared with 2D denoising methods, BM3D-SAPCA method searches similar blocks stacks them...
We demonstrate a short-time long distance distributed high-temperature sensing by non-local Haar transform (NLH) in optical frequency domain reflectometry (OFDR). By searching similar pixels across region, NLH makes good use of incomplete space similarity information contained 3D cross-correlation distribution local Rayleigh scattering spectra measured OFDR, which can be used to enhance image denoising performance and retain rare details original data. With the proposed method, we have...