A5055778401- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Cancer Immunotherapy and Biomarkers
- Child Development and Digital Technology
- IL-33, ST2, and ILC Pathways
- Impact of Technology on Adolescents
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Esophagitis
- Health, psychology, and well-being
- Antimicrobial Peptides and Activities
- Bioinformatics and Genomic Networks
- Genetic diversity and population structure
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Helicobacter pylori-related gastroenterology studies
- RNA and protein synthesis mechanisms
- Dermatology and Skin Diseases
- Social Media and Politics
- Cell Adhesion Molecules Research
University of Akureyri
2013-2025
deCODE Genetics (Iceland)
2001-2010
University of Iceland
2004
Karolinska Institutet
1992-2001
Children's Hospital of Philadelphia
2001
University of Pennsylvania
2001
Bambino Gesù Children's Hospital
1997
University of Rome Tor Vergata
1997
Sapienza University of Rome
1995
KTH Royal Institute of Technology
1993
The variable clinical response seen with most cancer immunotherapy suggests that there is a large interindividual variation in immunologic to tumors. One of the key functional parameters an immune local production cytokines. As method survey status tumor-infiltrating cells, we have investigated constitutive expression cytokine mRNA biopsies from epithelial ovarian carcinomas by using PCR-assisted amplification assay. Using set cytokine-specific primers for 10 different cytokines, found...
We have compared the variable region 3 sequences from 10 human immunodeficiency virus type 1 (HIV-1)-infected infants to corresponding mothers. The were derived DNA of uncultured peripheral blood mononuclear cells (PBMC), cultured PBMC, and RNA serum collected at or shortly after delivery. infected infants, in contrast mothers, harbored homogeneous populations. Comparison children clones mothers showed that transmitted represented either a minor major population mother. In an earlier study,...
Gene expression profiles were examined in freshly isolated peripheral blood mononuclear cells (PBMC) from two independent cohorts (training and test sets) of glucocorticoid (GC)-sensitive ( n = 64) GC-resistant 42) asthma patients search genes that accurately predict responders nonresponders to inhaled corticosteroids. A total 11,812 with high-density oligonucleotide microarrays both resting PBMC (106 patients) treated vitro IL-1β TNF-α combined (88 patients), or without GC. 5,011 expressed...
Abstract Freshly isolated tumor‐infiltrating lymphocytes (TIL) are often functionally deficient. Since one of the key functional parameters an immune response is local production cytokines, we studied expression cytokine genes in freshly renal cancer tissue. Using a PCR‐assisted mRNA amplification assay, constitutive for 10 different cytokines was assessed We compared samples carcinomas, cell lines established from tumor samples, peripheral blood mononuclear cells (PBMC) and non‐tumor kidney...
Increased levels of serum IgE and eosinophilia have been described in human immunodeficiency virus (HIV) infection, almost exclusively patients with CD4+ cell count < 200 cells/microliters. production is regulated by T helper type 2 (Th-2) lymphocytes, producing interleukin 4 (IL-4) expressing a ligand for the B cell-specific CD40 molecule (CD40 [L]). A shift to Th-2-like pattern cytokine secretion has postulated be associated progression toward acquired syndrome (AIDS). We studied...
Abstract Little information is available about the generation and specificity of cytotoxic cells that eliminate human monocytes/macrophages infected with mycobacteria. To address this we have developed a cytotoxicity assay in which 51 Cr‐labeled monocytes pulsed bacillus Calmette Guérin (BCG) or Myco‐bacterium leprae , were used as target overnight assays. As effector cells, peripheral blood mononuclear from healthy occupational contacts leprosy patients stimulated antigen for 7 days used....
Numerous asthma and atopy loci have been reported in studies demonstrating associations of the asthma-related phenotypes atopy, elevated IgE levels, bronchial hyperresponsiveness with alleles microsatellite markers single-nucleotide polymorphisms (SNPs) within specific cytokine/chemokine IgE-regulating genes. Although reporting these observations are compelling, most them lack statistical power. We assessed nature, pattern, frequency SNPs 24 candidate genes Iceland looked for atopy....
Background As parental burnout is increasingly recognised for its severe impact on parents and children, identifying factors that exacerbate or alleviate this condition crucial. Reliable assessment tools in clinical settings are essential to detect those at risk of experiencing burnout, enabling timely intervention.
Abstract Objectives The ICEPAIN study is a longitudinal research project focused on building an extensive database health-related quality of life (HRQoL), lifestyle, and pain among the general population in Iceland. started with cross-sectional data collection will be followed by similar after 5 10 years from participants who have agreed to contacted again. In this article, descriptive prevalence nature chronic Icelandic presented relation sociodemographic factors, adverse experiences,...
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Abstract The T cell receptor (TCR) variable (V) gene repertoire was analyzed in patients with monoclonal gammopathy of undetermined significance (MGUS) ( n = 17), multiple myeloma (MM) stage I 16), MM stages II/III 31) and agematched controls 27) by immunofluorescence flow cytometry using a panel mouse antibodies (mAb) 10) against TCR Vα Vβ products. expansion defined as value ⩾ thrice the normal median for each respective V mAb. Fifty‐three percent all displayed CD8 + expansion(s) compared...
Psychological distress can cause burnout, which affects mental and physical well-being. It is important to identify factors associated with psychological discomfort how nurses deal these problems.
Objective To determine viral characteristics and the protective effect of virus neutralizing antibodies in mother-to-child transmission HIV-1. Molecular studies Ten HIV-1-infected mother-child pairs were sampled within 4 months delivery. Variable region 3 envelope was amplified by nested polymerase chain reaction sequenced, directly and/or after cloning, solid-phase DNA sequencing. The amino acid sequence variable from all 10 children homogeneous, whereas mothers showed varying degrees...
We have previously reported a preferential usage of V delta 1/V gamma 8 on TCR-gamma-delta-bearing intraepithelial lymphocytes the normal human intestine as well in inflamed synovial tissue patients with rheumatoid arthritis. The aim present study was to analyze gene segment by T cells and peripheral blood (PB) from inflammatory bowel disease. Freshly isolated were analyzed flow cytometry using panel subset-specific mAbs. relative proportion PB TCR-gamma delta+ increased Crohn's disease...
We have analyzed the V-gene usage in gamma delta T cells of human gut and joint by using a new mAb (B18) specific for V 8 TCR-gamma delta+ cells. The B18+ population constituted minor subset peripheral blood (PB) healthy persons (6 +/- 5%) only 1 35 cell clones was positive. In contrast, dominant among intraepithelial lymphocytes (IEL) derived from intestine (74 29, p < 0.002), two three IEL patients with coeliac disease were B18+. Interestingly, higher proportion found synovial fluid...
We have analysed the ability of T cells from synovial fluid mononuclear (SFMC) and peripheral blood (PBMC) inflammatory arthritic diseases to proliferate in response mycobacterial antigens (65‐kDa heal shock protein [hsp] BCG. whole BCG) rat collagen type II. The SFMC demonstrated a significantly greater respond 65‐kDa hsp BCG, compared with PBMC same patients, With II, only small proportion patients showed proliferative response, although this antigen also responded better than PBMC. There...
Objective: To evaluate sequence evolution in relation to different rates of disease progression infants infected with HIV-1. Design: Variability the gp120 V3 region was analysed HIV-1-infected children clinical courses, slow (n = 2) versus progressive 3). Methods: Cloning and sequencing virus-derived DNA from uncultured peripheral blood mononuclear cells performed at two three timepoints birth up fifth year life. Sequence variability estimated by calculating genetic distance proportion ratio...