A5086336375- Nanoplatforms for cancer theranostics
- Prostate Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoparticle-Based Drug Delivery
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- RNA Research and Splicing
- Immune cells in cancer
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
Institut d'Investigació Biomédica de Bellvitge
2023-2024
Cyceron
2019
PSA screening has led to an over-diagnosis of prostate cancer (PCa) and unnecessary biopsies benign conditions due its low specificity. Consequently, more accurate, preferentially non-invasive, tests are needed. We aim evaluate the potential semen sEV (small extracellular vesicles) tsRNAs (tRNA-derived small RNAs) as PCa indicators. Initially, following a literature review in OncotRF database high-throughput RNA-sequencing studies tissue together with sncRNA profile sEVs, we selected four...
Small RNA-sequencing (small RNA-seq) has revealed the presence of small RNA-naturally occurring variants such as microRNA (miRNA) isoforms or isomiRs. Due to their size and sequence similarity among miRNA isoforms, validation by RT-qPCR is challenging. We previously identified two miR-31-5p isomiRs-the canonical a 3'isomiR variant (3' G addition)-which were differentially expressed between individuals with azoospermia different origin. Here, we sought determine discriminatory capacity these...