A5062483864- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Biochemical and Structural Characterization
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- Diet and metabolism studies
- Chemical Synthesis and Analysis
- Microbial metabolism and enzyme function
- Toxic Organic Pollutants Impact
- Influenza Virus Research Studies
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Phenothiazines and Benzothiazines Synthesis and Activities
- Mitochondrial Function and Pathology
- Computational Drug Discovery Methods
- Adipose Tissue and Metabolism
- Enzyme Structure and Function
- Antibiotic Use and Resistance
- Per- and polyfluoroalkyl substances research
- Microbial Metabolism and Applications
- Monoclonal and Polyclonal Antibodies Research
University of Padua
2020-2025
The current trend dealing with the production of per- and polyfluoroalkyl substances (PFASs) involves shifting toward branched short-chain fluorinated compounds known as new-generation PFASs. A key aspect to be clarified, address adverse health effects associated exposure PFASs, is their binding mode human serum albumin (hSA), most abundant protein in plasma. In this study, we investigated interaction between hSA two representative namely, HPFO-DA C6O4. In-solution studies revealed that both...
Antimicrobial resistance poses a severe threat to human health and Pseudomonas aeruginosa stands out among the pathogens responsible for this emergency. The SOS response DNA damage is crucial in bacterial evolution, influencing development adaptability challenging environments, especially under antibiotic exposure. Recombinase A (RecA) transcriptional repressor LexA are key players that orchestrate process, determining either silencing or active transcription of genes their control. By...
Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed preserve these important antibacterial drugs. Here, we describe a series 1,2,4-triazole-3-thione-based displaying an α-amino acid substituent, which amine was mono- or disubstituted by (hetero)aryl groups. Compounds certain nitrogen-containing heterocycles showed submicromolar activities against VIM-type enzymes strong...
SARS-CoV-2 is the pathogen responsible for most recent global pandemic, which has claimed hundreds of thousands victims worldwide. Despite remarkable efforts to develop an effective vaccine, concerns have been raised about actual protection against novel variants. Thus, researchers are eager identify alternative strategies fight this pathogen. Like other opportunistic entities, a key step in lifecycle maturation envelope glycoprotein at RARR685↓ motif by cellular enzyme Furin. Inhibition...
Abstract Macrocyclic peptides provide an attractive modality for drug development due to their ability bind challenging targes, small size, and amenability powerful in vitro evolution techniques such as phage or mRNA display. While these technologies proved capable of generating screening extremely large libraries yielded ligands already many targets, they often do not identify the best binders within a library difficulty monitoring performance controlling selection pressure. Furthermore,...
Aiming at expanding the portfolio of Old Yellow Enzymes (OYEs), which have been systematically studied to be employed in chemical and pharmaceutical industries as useful biocatalysts, we decided explore immense reservoir filamentous fungi. We drew from genome two Ascomycetes Aspergillus niger Botryotinia fuckeliana four new members OYE superfamily belonging classical thermophilic-like subfamilies. The BfOYEs show wider substrate spectra than AnOYE homologues, appear more specialized...
Abstract Antimicrobial resistance represents a major threat to human health and Pseudomonas aeruginosa stands out among the pathogens responsible for this emergency. The SOS response DNA damage plays pivotal role in bacterial evolution, driving development of mechanisms influencing adaptability populations challenging environments, particularly context antibiotic exposure. Recombinase A (RecA) transcriptional repressor LexA are key players that orchestrate process, determining either...
The worldwide emergence and dissemination of Gram-negative bacteria expressing metallo-β-lactamases (MBLs) menace the efficacy all β-lactam antibiotics, including carbapenems, a last-line treatment usually restricted to severe pneumonia urinary tract infections. Nonetheless, no MBL inhibitor is yet available in therapy. We previously identified series 1,2,4-triazole-3-thione derivatives acting as micromolar inhibitors MBLs vitro, but devoid synergistic activity microbiological assays. Here,...