A5093242808- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Antibiotic Resistance in Bacteria
- Fluorine in Organic Chemistry
- Neurotransmitter Receptor Influence on Behavior
- Allergic Rhinitis and Sensitization
- Oral Health Pathology and Treatment
- Mass Spectrometry Techniques and Applications
- Synthesis and Biological Evaluation
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Per- and polyfluoroalkyl substances research
- Metabolomics and Mass Spectrometry Studies
- Trypanosoma species research and implications
- Lichen and fungal ecology
- Cannabis and Cannabinoid Research
- Aldose Reductase and Taurine
- Research on Leishmaniasis Studies
University of Modena and Reggio Emilia
2023-2025
University of Turin
2024
AKR1C3 is an enzyme that overexpressed in several types of radiotherapy- and chemotherapy-resistant cancers. Despite a validated target for drug development, no inhibitor has been approved clinical use. In this manuscript, we describe our study new series potent AKR1C3-targeting 3-hydroxybenzoisoxazole based inhibitors display high selectivity over the AKR1C2 isoform low micromolar activity inhibiting 22Rv1 prostate cancer cell proliferation. silico studies suggested proper substituents to...
p-Cresol, an environmental contaminant and endogenous metabolite derived primarily from the conversion of l-tyrosine by intestinal microflora, is gaining increasing attention, due to its potential impact on human health. Recent studies have highlighted elevated levels p-cresol metabolites, including p-cresyl sulfate glucuronide, in various populations, suggesting a correlation with neurodevelopmental neurodegenerative conditions. While role this compound as uremic toxin well established,...
Abstract Cannabidiol (CBD) is the main non-psychoactive phytocannabinoid derived from Cannabis sativa L. It now an active pharmaceutical ingredient (API), given its usage in treating some types of pediatric epilepsy. For this reason, compound requires a deep characterization terms purity and origin. Previous research work has shown two impurities CBD samples hemp inflorescences, namely, cannabidivarin (CBDV) cannabidibutol (CBDB), while abnormal-cannabidiol (abn-CBD) been described as...
Abstract Per- and poly-fluorinated compounds constitute a wide group of fluorocarbon chemicals with widespread industrial applications, ranging from non-stick coating in cookware to water surfactants, fire-fighting foams water-repellent coatings on textiles. Presently, over 12,000 PFAS are known worldwide. In recent years, extensive research has focused investigating the biological effects these molecules various organisms, including humans. Here, we conducted silico simulations examine...
The worldwide emergence and dissemination of Gram-negative bacteria expressing metallo-β-lactamases (MBLs) menace the efficacy all β-lactam antibiotics, including carbapenems, a last-line treatment usually restricted to severe pneumonia urinary tract infections. Nonetheless, no MBL inhibitor is yet available in therapy. We previously identified series 1,2,4-triazole-3-thione derivatives acting as micromolar inhibitors MBLs vitro, but devoid synergistic activity microbiological assays. Here,...