A5050723989- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Radiopharmaceutical Chemistry and Applications
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Hemoglobin structure and function
- Antibiotic Resistance in Bacteria
- Polyamine Metabolism and Applications
- Antimicrobial Resistance in Staphylococcus
- Synthesis and Biological Evaluation
- Sulfur Compounds in Biology
- Heme Oxygenase-1 and Carbon Monoxide
- Electron Spin Resonance Studies
- Streptococcal Infections and Treatments
- Advanced Chemical Sensor Technologies
- Liver physiology and pathology
- Biopolymer Synthesis and Applications
- Cannabis and Cannabinoid Research
- Tuberculosis Research and Epidemiology
- Molecular Sensors and Ion Detection
- Lanthanide and Transition Metal Complexes
- Supramolecular Self-Assembly in Materials
- Photochromic and Fluorescence Chemistry
University of Turin
2018-2025
Torino e-district
2021
King's College London
2021
University of Catania
2018-2020
D-galactose, a simple natural compound, has been investigated as powerful scaffold for drug delivery, diagnostics, and theranostics due to its distinctive properties interactions with specific cell receptors. In the field of galactose functions ligand selectively target cells expressing receptors, such hepatocytes, macrophages, cancer cells. The direct attachment main or drug-loaded nanoparticles liposomes enhances cellular uptake, thereby improving delivery intended Galactose also found be...
Hydrogen peroxide (H
Siderophore production, along with heme scavenging by hemophores, is one of the main mechanisms exploited bacteria to achieve an adequate iron supply. Staphylococcus aureus produces two siderophores, staphyloferrin A (SA) and B (SB), latter produced only most invasive, coagulase-positive S. strains. Along seven steps SB biosynthetic pathway, N-(2-amino-2-carboxyethyl)-l-glutamate synthase (SbnA) catalyzes crucial formation intermediate from O-phospho-L-serine glutamate. Our functional...
Two novel NO photodonors (NOPDs) based on BODIPY and Rhodamine antennae activatable with the highly biocompatible green light are reported. Both NOPDs exhibit considerable fluorescence emission release remarkable quantum efficiencies. The combination of photoreleasing emissive performance for both compounds is superior to those exhibited by other similar light-harvesting centres, making them very intriguing image-guided phototherapeutic applications. Preliminary biological data prove their...
Excitation of a molecular hybrid with highly biocompatible red light generates cytotoxic peroxynitrite, produces fluorescence useful for cell tracking and induces remarkable cancer death at very low concentrations doses.
The biological activity of a molecular hybrid (DXNO-GR) joining doxorubicin (DOX) and an N-nitroso moiety releasing nitric oxide (NO) under irradiation with the biocompatible green light has been investigated against DOX-sensitive (MCF7) -resistant (MDA-MB-231) breast cancer cells in vitro. DXNO-GR shows significantly higher cellular internalization than DOX both cell lines and, contrast to DOX, does not experience efflux MDR overexpressing MDA-MB-231 cells. seems be mediated by bovine serum...
Abstract A few compounds in which the nitric oxide (NO) photodonor N ‐[4‐nitro‐3‐(trifluoromethyl)phenyl]propane‐1,3‐diamine is joined to mitochondria‐targeting alkyltriphenylphosphonium moiety via flexible spacers of variable length were synthesized. The lipophilicity products was evaluated by measuring their partition coefficients n ‐octanol/water. obtained values, markedly lower than those calculated, are consistent with likely collapsed conformation assumed solution, as suggested...
In this contribution, we report a novel entirely photocontrolled nanoplatform comprising binary mixture of pluronic copolymers capable self-assembling into core-shell micelles and co-entrapping two photoactivatable components: benzoporphyrin photosensitizer for photodynamic therapy (PDT) coumarin-photocaged chemotherapeutic agent Chlorambucil (CAB). The resulting supramolecular micellar assembly is about 30 nm in diameter with polydispersity index <0.1, stable more than 72 h, exhibits...
A novel NO photodonor operates through excitation with highly biocompatible green light of the widely used chemotherapeutic agent doxorubicin as light-harvesting antenna without precluding its typical red emission and DNA binding properties.
The application of gaseous signaling molecules like NO, H2S or CO to overcome the multidrug resistance in cancer treatment has proven be a viable therapeutic strategy. development CO-releasing (CORMs) controlled manner and targeted tissues remains challenge medicinal chemistry. In this paper, we describe design, synthesis chemical enzymatic stability novel non-metal CORM (1) able release intracellularly and, simultaneously, facilitate fluorescent degradation products under action esterase....
Abstract Human hemoglobin (Hb) is the preferred iron source of Staphylococcus aureus . This pathogenic bacterium exploits a sophisticated protein machinery called Iron-regulated surface determinant (Isd) system to bind Hb, extract and internalize heme, finally degrade it complete acquisition. IsdB, exposed Hb receptor, proven virulence factor S. inhibition its interaction with can be pursued as strategy develop new classes antimicrobials. To identify small molecules able disrupt IsdB:Hb...
The worldwide emergence and dissemination of Gram-negative bacteria expressing metallo-β-lactamases (MBLs) menace the efficacy all β-lactam antibiotics, including carbapenems, a last-line treatment usually restricted to severe pneumonia urinary tract infections. Nonetheless, no MBL inhibitor is yet available in therapy. We previously identified series 1,2,4-triazole-3-thione derivatives acting as micromolar inhibitors MBLs vitro, but devoid synergistic activity microbiological assays. Here,...
Core-shell micelles of pluronic copolymers co-entrap a benzoporphyrin photosensitizer and the chemotherapeutic Chlorambucil, which is temporarily inactivated, through coumarin photocage. Photoexcitation this nanoassembly with visible light leads to simultaneous generation cytotoxic singlet oxygen uncaging in its active form, resulting an amplified anticancer activity against MCF-7 human breast adenocarcinoma cells. More information can be found Full Paper by S. Sortino et al. on page 7664.
Photoactivation of two novel BODIPY and Rhodamine-based molecular hybrids with the highly biocompatible green light triggers NO release from nitroso aniline-derivative appendages without precluding typical orange-green fluorescence emission antennae units, making them intriguing systems for image-guided phototherapeutic applications where controlled delivery is required. More information can be found in Full Paper by L. Lazzarato, S. Sortino, et al. on page 11080.
c-Met is a receptor tyrosine kinase which, after activation by its ligand, the hepatocyte growth factor (HGF), mediates range of intracellular signalling pathways including some related to proliferation, motility, migration and invasion cancer cells. Aberrant HGF/c-Met involved in development metastatic progression several tumour types. Thus, this protein key player initiation progression. For reason, monitoring expression real time likely assist diagnosis response therapy. Positron emission...