A5076654307- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Phytochemistry Medicinal Plant Applications
- Protein Interaction Studies and Fluorescence Analysis
- Advanced Drug Delivery Systems
- Pancreatic and Hepatic Oncology Research
- Photochemistry and Electron Transfer Studies
- Mesoporous Materials and Catalysis
- Electrochemical Analysis and Applications
- Photoacoustic and Ultrasonic Imaging
- Heavy Metal Exposure and Toxicity
- Lanthanide and Transition Metal Complexes
- Nanoparticles: synthesis and applications
- ATP Synthase and ATPases Research
- Advanced Nanomaterials in Catalysis
- Genomic variations and chromosomal abnormalities
- Copper-based nanomaterials and applications
- Neurogenesis and neuroplasticity mechanisms
- Luminescence and Fluorescent Materials
- Geography and Environmental Studies
- Biochemical and biochemical processes
- Gold and Silver Nanoparticles Synthesis and Applications
Italian Institute of Technology
2024
Universidade de São Paulo
2020-2023
Nanomed (Brazil)
2018-2022
Universidade Estadual de Maringá
2012-2021
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2014-2021
Institut de Science et d'Ingénierie Supramoléculaires
2020
Université de Strasbourg
2020
Centre National de la Recherche Scientifique
2020
Azienda Sanitaria Locale Alessandria
2015-2016
Universidade Estadual de Londrina
2012
Abstract Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB‐modified MSNs have shown relevant photostability and high efficiency in the photoproduction delivery of singlet oxygen ( 1 O 2 ), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests evidenced that RB‐MSNs are able to reduce cell proliferation one most aggressive skin cancer types (SK‐MEL‐28) after...
Rose Bengal incorporated into mesostructured silica nanoparticles exhibits efficient singlet oxygen (<sup>1</sup>O<sub>2</sub>) generation when illuminated with 540 nm light which is particularly promising for PDT applications.
The synthesis and characterization of amino-functionalized mesoporous silica nanoparticles are presented following two different synthetic methods: co-condensation post-synthesis grafting 3-aminopropyltriethoxysilane. amino groups' distribution on the was evaluated considering aggregation state a grafted photosensitizer (Verteporfin) by using spectroscopic techniques. homogeneous groups within network is key factor to avoid during further organic functionalization optimize performance...
A theranostic nanoplatform coupling optical-imaging with photodynamic-therapy was prepared by using Rhodamine B as a contrast agent and verteporfin photosensitizer.
Cancer is the second leading cause of death globally and responsible, where about 1 in 6 deaths world. Therefore, there a need to develop effective antitumor agents that are targeted only specific site tumor improve efficiency cancer diagnosis treatment and, consequently, limit unwanted systemic side effects currently obtained by use chemotherapeutic agents. In this context, due its unique physical chemical properties graphene oxide (GO), it has attracted interest biomedicine for therapy.
It was evaluated the properties of xanthene dyes Erythrosin B, Eosin Y and theirs Methyl, Butyl Decyl ester derivatives as possible photosensitizers (PS) for photodynamic treatments. The more hydrophobic self-aggregate in water/ethanol solutions above 70% water (vol/vol) mixture. In buffered water, these PS were encapsulated Pluronic polymeric surfactants P-123 F-127 by two methodologies: direct addition thin-film solid dispersion methods. method provided formulations with higher stabilities...
Orange wood biomass is an interesting lignocellulosic material, but its lignin has been little explored. As a structural macromolecule present in the plant cell wall, used nanoencapsulation and nanomedicine, standing out as good drug carrier. In this study, was extracted by soda pulping process to produce nanoparticles for curcumin encapsulation subsequent application photodynamic therapy (PDT). The were synthesized solvent shifting characterized with UV–vis, fluorescence, dynamic light...
Astonishingly, 3-hydroxyisonicotinealdehyde (HINA) is despite its small size a green-emitting push–pull fluorophore in water (QY of 15%) and shows ratiometric emission response to biological relevant pH differences (p K a2 ∼ 7.1).
A highly efficient nanoplatform for photodynamic therapy was obtained by covalent conjugation of verteporfin with mesoporous silica nanoparticles. Verteporfin has an intense absorption band in the red region Vis spectrum ensuring a deeper tissue penetration; this feature makes verteporfin-based formulations particularly attractive vivo PDT applications. The loading, dispersion and efficiency photoproduction delivery singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced...
Sol-gel synthesis is commonly used to modify the surface of mesoporous silica nanoparticles (MSN) with organic groups through co-condensation method.The template removal, and site-controlled addition their partial occlusion inside framework walls are still a challenge in one-pot synthesis.Here, we optimize amino-modified MSN by combination efficient removal methodology precise time amino precursor achieve superb material.The after growth process produces sample significantly higher amount NH...
Photodynamic therapy (PDT) is promising for bacterial inactivation since cellular internalization of photosensitizers (PS) not crucial the treatment effectiveness. Photoinduced damage in lipid envelope may already induce microbial inactivation, which requires PS capable easily penetrating into membrane. Herein, we report on insertion eosin decyl ester (EosDec) Langmuir films 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (DOPG), and...
pK a .An experiment was proposed applying the Chemometric approach of Multivariate Analysis for inclusion in undergraduate Chemistry courses to promote and expand use this analytical-statistical tool.The entails determination acid dissociation constant dyes via UV-Vis electronic spectrophotometry.The used show from simple equilibrium very complex systems involving up four protolytic species with high spectral overlap.The methodology more efficient than univariate methods.For classes, it is...
Plasmonic nanoparticles (NPs) have been extensively investigated as active materials for application in the optoelectronics, photocatalysis, and electrochemistry fields. In particular, doped metal oxides attracted significant interest because of their optical electrical properties. this study, we influence aluminum, gallium, indium on doping process zinc oxide (ZnO) NPs. Physicochemical characterization revealed that, upon doping, ZnO NPs exhibited enhanced optoelectronic properties,...
PHOTODYNAMIC ACTION AGAINST Artemia salina