A5058709121- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Synthesis of Organic Compounds
- Skin Protection and Aging
- Antimicrobial Peptides and Activities
- Genomics, phytochemicals, and oxidative stress
- Bee Products Chemical Analysis
- Forensic Toxicology and Drug Analysis
- Graphene and Nanomaterials Applications
- Synthesis and biological activity
- Plant chemical constituents analysis
- Porphyrin and Phthalocyanine Chemistry
- Biochemical and Structural Characterization
- Photochromic and Fluorescence Chemistry
- Light effects on plants
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Psychedelics and Drug Studies
- Retinoids in leukemia and cellular processes
- Synthesis and Reactivity of Heterocycles
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
Pharmacy Research UK
2025
Istituto Oncologico Veneto
2024-2025
University of Padua
2017-2024
Institute of Ionized Gas
2021
The development of new photodynamic therapy (PDT) agents designed for bladder cancer (BC) treatments is utmost importance to prevent its recurrence and progression towards more invasive forms. Here, three different porphyrinic photosensitizers (PS) (TMPyP, Zn-TMPyP, P1-C5) were non-covalently loaded onto graphene oxide (GO) or quantum dots (GQDs) in a one-step process. cytotoxic effects the free PS corresponding hybrids compared upon blue (BL) red-light (RL) exposure on T24 human BC cells....
Excitation of a molecular hybrid with highly biocompatible red light generates cytotoxic peroxynitrite, produces fluorescence useful for cell tracking and induces remarkable cancer death at very low concentrations doses.
Nineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to 6,7-dihydroindolizin-8(5H)-one 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]azepine-9-one moieties obtain potential photosensitizing agents. They tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, dark under UVA light (2.0 J/cm2). We demonstrated that toxicity, only when...
In the last years, monoclonal antibodies (mAbs) have rapidly escalated as biopharmaceuticals into cancer treatments, mainly for their target specificity accompanied by less side effects than traditional chemotherapy, and stimulation of reliable long-term anti-tumoral responses. They are potentially unstable macromolecules under shaking, temperature fluctuations, humidity, indoor outdoor light exposure, all stressors occurring throughout production, transport, storage, handling,...
Triple-negative breast cancer (TNBC) is an aggressive subtype of still lacking effective treatment options. Chemotherapy in combination with immunotherapy can restrict tumor progression and repolarize the microenvironment towards anti-tumor milieu, improving clinical outcome TNBC patients. The chemotherapeutic drug paclitaxel has been shown to induce immunogenic cell death (ICD), whereas inhibitors indoleamine 2,3- dioxygenase 1 (IDO1) enzyme, whose expression shared immune regulatory cells,...
Exploiting the tumor environment features (EPR effect, elevated glutathione, reactive oxygen species levels) might allow attaining a selective and responsive carrier capable of improving therapeutic outcome. To this purpose, in situ covalent binding drugs nanoparticles to circulating human serum albumin (HSA) represent pioneering approach achieve an effective strategy. This study describes synthesis, vitro vivo evaluation bioresponsive HSA-binding (MAL-PTX2S@Pba), co-delivering two different...
Skin is the essential barrier of human body which performs multiple functions. Endogenous factors, in concert with external assaults, continuously affect skin integrity, leading to distinct structural changes that influence not only appearance but also its various physiological Alterations functions lead an increased risk developing disease and side reactions, thus importance maintaining integrity epidermal slowing down aging process evident. Salvia haenkei (SH) has been recently identified...
Cancer therapy is still a challenging issue. To address this, the combination of anticancer drugs with other therapeutic modalities, such as light-triggered therapies, has emerged promising approach, primarily when both active ingredients are provided within single nanosystem. Herein, we describe unprecedented preparation tumor microenvironment (TME) responsive nanoparticles exclusively composed paclitaxel (PTX) prodrug and photosensitizer pheophorbide A (PheoA), e.g., PheoA≅PTX2S. This...
The biological activity of a molecular hybrid (DXNO-GR) joining doxorubicin (DOX) and an N-nitroso moiety releasing nitric oxide (NO) under irradiation with the biocompatible green light has been investigated against DOX-sensitive (MCF7) -resistant (MDA-MB-231) breast cancer cells in vitro. DXNO-GR shows significantly higher cellular internalization than DOX both cell lines and, contrast to DOX, does not experience efflux MDR overexpressing MDA-MB-231 cells. seems be mediated by bovine serum...
Drugs incorporated into hair are exposed to the environment, and cosmetic chemical treatments, with possible decreases in their content. Knowledge concerning effect of sunlight on drug content can be helpful forensic toxicologists, particular, when investigating concentrations above or below pre-determined cut-offs. Twenty authentic positive samples were selected which had previously tested for amphetamines and/or ketamine. Washed divided two identical strands, former at 765 W/m² (300⁻800 nm...
In the large field of bioactive peptides, peptaibols represent a unique class compounds. They are membrane-active produced by fungi genus Trichoderma and known to elicit plant defenses. Among short-length peptaibols, trichogin GA IV is nonhemolytic, proteolysis-resistant, antibacterial, cytotoxic. Several analogs endowed with potent activity against phytopathogens, thus representing sustainable alternative copper for protection. this work, we tested breast cancer cell line normal same...
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium responsible for severe nosocomial infections and considered a critical pulmonary pathogen both immunocompromised cystic fibrosis patients. Planktonic cells of P. possess intrinsic acquired resistances, inactivating several classes conventional antibiotics. Additionally, this can grow, forming biofilms, complex structures, further hampering the action multiple Here, we report biological properties D-Q53 CecB, all-D enantiomer...
Drugs incorporated into hair are exposed to the environment, and cosmetic chemical treatments, with possible decreases in their content. Knowledge concerning effect of sunlight on drug content can be helpful forensic toxicologists, particular, when investigating concentrations above or below pre-determined cut-offs. Twenty-eight authentic positive samples were selected which had previously tested for ethyl glucuronide (EtG). Washed divided two identical tufts, former at 13,219 J/cm2 (300-800...
Abstract Objectives Furocoumarins (psoralens and angelicins) have been already used under ultraviolet A light ( UVA ) for the treatment of skin diseases cutaneous T‐cell lymphoma. Besides their high anti‐proliferative activity, some severe long‐term side effects observed, example genotoxicity mutagenicity, likely strictly related to formation crosslinks. It has demonstrated that blue BL activation 8‐methoxypsoralen, an FDA ‐approved drug, leads less mutagenic monoadducts in DNA . So far,...
A coordinated action between nuclear and mitochondrial activities is essential for a proper cellular response to genotoxic stress. Several transcription factors, including STAT3, translocate mitochondria exert function regulation; however, the role of STAT3 (mitoSTAT3) under stressed conditions still poorly understood. In this study, we examined whether stable expression mitoSTAT3 wild-type or mutated at conserved serine residue (Ser727), which involved in can affect DNA damage UVC...
Triple-negative breast cancer (TNBC) is an aggressive subtype of still lacking effective treatment options. Chemotherapy in combination with immunotherapy can restrict tumor progression and repolarize the microenvironment towards anti-tumor milieu, improving clinical outcome TNBC patients. The chemotherapeutic drug paclitaxel had been shown to induce immunogenic cell death (ICD), whereas inhibitors indoleamine 2,3-dioxygenase 1 (IDO1), whose expression shared immune regulatory cells, have...
Peptaibols are proteolysis-resistant, membrane-active peptides. Their remarkably stable helical 3D-structures key for their bioactivity. They can insert themselves into the lipid bilayer as barrel staves, or lay on its surface like carpets, depending both length and thickness of bilayer. Medium-length peptaibols particular interest studying peptide-membrane interaction because allows them to adopt either orientation a function membrane thickness, which, in turn, might even result an enhanced...
Background: Drug incorporated in hair are exposed to the environment and cosmetic chemical treatments, with possible decrease of their content. Knowledge concerning effect sun light on drug content can be helpful forensic toxicologist, particular when investigating concentrations above or below pre-determined cut-offs. Materials Methods: Twenty authentic positive samples were selected that had previously tested for amphetamines and/or ketamine. Washed hairs divided into two identical...