A5067717488- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Dyeing and Modifying Textile Fibers
- Nanoparticle-Based Drug Delivery
- Skin Protection and Aging
- Prostate Cancer Treatment and Research
- Silk-based biomaterials and applications
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Enzyme Production and Characterization
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Photonic Crystals and Applications
- Hormonal and reproductive studies
- 3D Printing in Biomedical Research
- Advanced Photocatalysis Techniques
- Bone Tissue Engineering Materials
- Immunotherapy and Immune Responses
- Photochromic and Fluorescence Chemistry
- Radiopharmaceutical Chemistry and Applications
- Skin and Cellular Biology Research
- Enzyme function and inhibition
Institute of Organic Synthesis and Photoreactivity
2016-2025
National Research Council
2015-2025
Istituto Ortopedico Rizzoli
2018
University of Bologna
2018
National Academies of Sciences, Engineering, and Medicine
2016
Consorzio Roma Ricerche
2015
Institute of Organic Synthesis
2014
Bologna Research Area
2014
The androgen receptor (AR) represents the primary target for prostate cancer (PC) treatment even when disease progresses toward androgen-independent (AIPC) or castration-resistant (CRPC) forms. Because small chemical changes in structure of nonsteroidal AR ligands determine pharmacological responses AR, we developed a novel stereoselective synthetic strategy that allows sterically hindered C2-substituted bicalutamide analogues to be obtained. Biological and theoretical evaluations...
We studied the chemical-physical nature of interactions involved in formation adducts two-dimensional black phosphorus (2D BP) with organoboron derivatives a conjugated fluorescent molecule (pyrene). Time-resolved fluorescence spectroscopy showed stabilization effect 2D BP on all derivatives, particular for endowed boronic functionalities. Also, stronger modulation decay oxygen was registered one compared to corresponding derivative alone. Nuclear magnetic resonance experiments suspension...
Prostate cancer (PC) is the fifth leading cause of death in men, and androgen receptor (AR) represents primary target for PC treatment, even though disease frequently progresses toward androgen-independent forms. Most commercially available nonsteroidal antiandrogens show a common scaffold consisting two aromatic rings connected by linear or cyclic spacer. By taking advantage facile, one-pot click chemistry reaction, we report herein preparation small library novel 1,4-substituted triazoles...
Keratin is a structural protein of mammalian tissues and birds, representing the principal constituent hair, nails, skin, wool, hooves, horns, beaks, feathers, playing an essential role in protecting body from external harassment. Due to its intrinsic features such as biocompatibility, biodegradability, responsiveness specific biological environment, physical–chemical properties, keratin has been extensively explored production nanocarriers active principles for different biomedical...
Beatrice Costa was not included as a first co-author in the original publication [...]
Osteosarcoma therapy might be moving toward nanotechnology-based drug delivery systems to reduce the cytotoxicity of antineoplastic drugs and improve their pharmacokinetics. In this paper, we present, for first time, an extensive chemical in vitro characterization dual-loaded photo- chemo-active keratin nanoparticles as a novel system treat osteosarcoma. The are prepared from high molecular weight hydrosoluble keratin, suitably functionalized with photosensitizer Chlorin-e6 (Ce6) then loaded...
Taxanes are highly effective cytotoxic drugs for progressing breast cancer treatment. However, their poor solubility and high toxicity urge the development of innovative formulations potential clinical relevance.By using a simple straightforward aggregation method, we have generated paclitaxel (PTX) loaded in keratin nanoparticles (KER-NPs-PTX). Their activities were tested against human MCF-7 MDA MB 231 cell lines conventional two-dimensional (2D) cultures dynamic three-dimensional (3D)...
Prostate cancer (PC) represents the most common type of among males and is second leading cause death in men Western society. Current options for PC therapy remain unsatisfactory, since they often produce uncomfortable long-term side effects, such as impotence (70%) incontinence (5-20%) even first stages disease. Light-triggered therapies, photodynamic therapy, have potential to provide important advances treatment localized partially metastasized prostate cancer. We designed a novel...
The potential anticancer effect of fluoroquinolone antibiotics has been recently unveiled and related to their ability interfere with DNA topoisomerase II. We herein envisioned the design synthesis novel Ciprofloxacin Norfloxacin nitric oxide (NO) photo-donor hybrids explore synergistic antitumor exerted by scaffold NO eventually produced upon light irradiation. Anticancer activity, evaluated on a panel tumor cell lines, showed encouraging results IC50 values in low micromolar range. Some...
Chlorin e6-conjugated keratin nanoparticles were obtained and their effectiveness as carriers for cancer photodynamic therapy was demonstrated<italic>in vitro</italic>.
Photoactivatable keratin sponges were prepared from protein aqueous solutions by the freeze-drying method, followed photofunctionalization with two different photosensitizers (PS): Azure A (AzA) and 5,10,15,20-tetrakis [4-(2-N,N,N-trimethylethylthio)-2,3,5,6-tetrafluorophenyl]porphyrin tetraiodide salt (TTFAP). The have a porosity between 49% 80% mean pore size in 37-80 μm range. As compared to AzA, TTFAP interacts more strongly as demonstrated lower PS release (6% vs 20%), decreased...
Triple-negative breast cancer (TNBC) is an aggressive subtype of still lacking effective treatment options. Chemotherapy in combination with immunotherapy can restrict tumor progression and repolarize the microenvironment towards anti-tumor milieu, improving clinical outcome TNBC patients. The chemotherapeutic drug paclitaxel has been shown to induce immunogenic cell death (ICD), whereas inhibitors indoleamine 2,3- dioxygenase 1 (IDO1) enzyme, whose expression shared immune regulatory cells,...
Exploiting the tumor environment features (EPR effect, elevated glutathione, reactive oxygen species levels) might allow attaining a selective and responsive carrier capable of improving therapeutic outcome. To this purpose, in situ covalent binding drugs nanoparticles to circulating human serum albumin (HSA) represent pioneering approach achieve an effective strategy. This study describes synthesis, vitro vivo evaluation bioresponsive HSA-binding (MAL-PTX2S@Pba), co-delivering two different...