A5048212753- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Prostate Cancer Diagnosis and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- DNA Repair Mechanisms
- Genital Health and Disease
- Prostate Cancer Treatment and Research
- Sexual function and dysfunction studies
- Protein Kinase Regulation and GTPase Signaling
- Hormonal and reproductive studies
- Urological Disorders and Treatments
- Virus-based gene therapy research
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Metal complexes synthesis and properties
- Silk-based biomaterials and applications
- Infectious Disease Case Reports and Treatments
- Effects of Radiation Exposure
University of Insubria
2015-2025
University of Milan
1998-1999
Centro de Neumologia Pediatrica
1988
In the present study we explored with a multidisciplinary approach, role of anandamide (AEA) in modulation anxiety behavior at level prefrontal cortex (PFC). Low doses metabolically stable AEA analog, methanandamide, microinjected into PFC, produced an anxiolytic-like response rats, whereas higher induced anxiety-like behaviors. Pretreatment selective antagonist CB1 or TRPV1 receptors (AM251 and capsazepine, respectively) suggested that anxiolytic effect evoked by might be due to interaction...
It has been recently reported that cannabidiol (CBD), a non-psychoactive cannabinoid, is able to kill glioma cells, both in vivo and vitro, independently of cannabinoid receptor stimulation. However, the underlying biochemical mechanisms were not clarified. In present study, we performed analysis effect CBD vivo, by using tumor tissues excised from nude mice, U87 cells. exposure significantly decreased activity content 5-lipoxygenase (LOX, approximately 40%), its end product leukotriene B4 (...
Patients with chronic prostatitis-chronic pelvic pain syndrome are difficult to treat due the unknown etiology and complex clinical presentation. Clinical phenotyping may better correlate multimodal treatment concepts than a current diagnosis. We evaluated novel system in database of patients at 2 European institutions correlated it patient symptoms. also investigated addition sexual dysfunction domain regard symptom correlation internal consistency.We retrospectively classified 937 from...
The complex network of etiological factors, signals and tissue responses involved in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) cannot be successfully targeted by a single therapeutic agent. Multimodal approaches to the therapy CP/CPPS have been are currently being tested, as frame diagnostic‑therapeutic phenotypic such urinary, psychosocial, organ‑specific, infection, neurological muscle tenderness (UPOINTS) system. In this study, effect combination on 914 patients...
Photodynamic therapy (PDT) is a therapeutic option for cancer, in which photosensitizer (PS) drugs, light, and molecular oxygen generate reactive species (ROS) induce cell death. First- second-generation PSs presented with problems that hindered their efficacy, including low solubility. Thus, loaded into nanocarriers were produced to enhance cellular uptake efficacy. Among other compounds investigated, the dye methylene blue (MB) showed potential as PS, its photodynamic activity tumor cells...
Abstract As enhanced chromosomal radiosensitivity (CRS) results from non‐ or misrepaired double strand breaks (DSBs) and is a hallmark for breast cancer single nucleotide polymorphisms (SNPs) in DSB repair genes, such as non homologous end‐joining (NHEJ) could be involved CRS genetic predisposition to cancer. In this study, we investigated the association of five SNPs three different NHEJ genes with population‐based case‐control setting. The total patient population composed selected group...
We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category II chronic bacterial prostatitis (CBP). The aim this study is to retrospectively compare microbiological clinical findings two treatment schemes for CBP based on azithromycin (500 mg, thrice-weekly) with a once-daily 500- or 750-mg dose ciprofloxacin (Cipro-500 Cipro-750 cohort, respectively). Combined administration (1500 mg week(-1)) at rate 750 day(-1) 4 weeks rather than 500 6...
Antibacterial fluoroquinolones have emerged as potential anticancer drugs, thus prompting the synthesis of novel molecules with improved cytotoxic characteristics. Ciprofloxacin and norfloxacin derivatives, previously synthesized by our group, showed higher potency than their progenitors. However, no information about mechanisms action was reported. In this study, we selected most active among these promising evaluated, on a panel breast (including those triple-negative) bladder cancer cell...
The potential anticancer effect of fluoroquinolone antibiotics has been recently unveiled and related to their ability interfere with DNA topoisomerase II. We herein envisioned the design synthesis novel Ciprofloxacin Norfloxacin nitric oxide (NO) photo-donor hybrids explore synergistic antitumor exerted by scaffold NO eventually produced upon light irradiation. Anticancer activity, evaluated on a panel tumor cell lines, showed encouraging results IC50 values in low micromolar range. Some...
Inflammatory processes are important components in the pathogenesis of many human cancers. According to 'injury and regeneration' model for prostate carcinogenesis, injury caused by pathogens or pro-inflammatory cytotoxic agents would trigger proliferation prostatic glandular cells, leading appearance epithelial lesions named 'Proliferative Atrophy' (PIA). cells infiltrating release genotoxic reactive oxygen species, atrophic neoplastic progression. The hypothesis pointing PIA as risk-lesion...
There is no consensus on the efficacy of antithrombotic drugs available for patients with intermittent claudication.A Medline and manual search was used to identify relevant publications. Uncontrolled or retrospective studies, double reports trials without clinical outcomes were excluded. Included studies graded as level 1 (randomised double- assessor-blind), 2 (open randomised), 3 (non-randomised comparative). Mortality, cerebro- cardiovascular events, amputations, arterial occlusions...
More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, clinical use AGs is hampered by nephrotoxicity ototoxicity, which often develop as a consequence prolonged courses therapy, administration increased doses these drugs. The discovery non-ototoxic antibacterial agents, showing wider spectrum activity, has gradually decreased first line...
Abstract Background A better understanding of the underlying mechanisms DNA repair after low- and high-LET radiations represents a research priority aimed at improving outcome clinical radiotherapy. To date however, our knowledge regarding importance DSB proteins in response human cells to radiation, is far from being complete. Methods We investigated radiosensitizing effect interfering with capacity mammary epithelial cell line (MCF10A) by lentiviral-mediated RNA interference (RNAi) Ku70...
Photoactivatable keratin sponges were prepared from protein aqueous solutions by the freeze-drying method, followed photofunctionalization with two different photosensitizers (PS): Azure A (AzA) and 5,10,15,20-tetrakis [4-(2-N,N,N-trimethylethylthio)-2,3,5,6-tetrafluorophenyl]porphyrin tetraiodide salt (TTFAP). The have a porosity between 49% 80% mean pore size in 37-80 μm range. As compared to AzA, TTFAP interacts more strongly as demonstrated lower PS release (6% vs 20%), decreased...
Photodynamic therapy (PDT) relies on the combined action of a photosensitizer (PS), light at an appropriate wavelength, and oxygen, to produce reactive oxygen species (ROS) that lead cell death. However, this therapeutic modality presents some limitations, such as poor water solubility PSs their limited selectivity. To overcome these problems, research has exploited nanoparticles (NPs). This project aimed synthesize PS, belonging BODIPY family, covalently link it two NPs differ in lipophilic...
Photodynamic therapy (PDT) is a minimally invasive treatment that uses the combination of photosensitizing agent (PS) and light to selectively target solid tumors, as well several non-neoplastic proliferating cell diseases. After systemic administration, PSs are activated by localized irradiation with visible light; in presence adequate concentrations molecular oxygen, this causes formation reactive oxygen species (ROS) subsequent tissue damage. In study, two series...