A5040495555- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Dyeing and Modifying Textile Fibers
- Cancer, Hypoxia, and Metabolism
- Skin Protection and Aging
- Layered Double Hydroxides Synthesis and Applications
- HIV/AIDS drug development and treatment
- Advanced Drug Delivery Systems
- Ferroelectric and Piezoelectric Materials
- Cancer therapeutics and mechanisms
- Supramolecular Self-Assembly in Materials
- Bone Tissue Engineering Materials
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
Institute of Organic Synthesis and Photoreactivity
2016-2024
National Research Council
2018-2024
University of Parma
2018
National Academies of Sciences, Engineering, and Medicine
2016
The potential anticancer effect of fluoroquinolone antibiotics has been recently unveiled and related to their ability interfere with DNA topoisomerase II. We herein envisioned the design synthesis novel Ciprofloxacin Norfloxacin nitric oxide (NO) photo-donor hybrids explore synergistic antitumor exerted by scaffold NO eventually produced upon light irradiation. Anticancer activity, evaluated on a panel tumor cell lines, showed encouraging results IC50 values in low micromolar range. Some...
Chlorin e6-conjugated keratin nanoparticles were obtained and their effectiveness as carriers for cancer photodynamic therapy was demonstrated<italic>in vitro</italic>.
Triple-negative breast cancer (TNBC) is an aggressive subtype of still lacking effective treatment options. Chemotherapy in combination with immunotherapy can restrict tumor progression and repolarize the microenvironment towards anti-tumor milieu, improving clinical outcome TNBC patients. The chemotherapeutic drug paclitaxel has been shown to induce immunogenic cell death (ICD), whereas inhibitors indoleamine 2,3- dioxygenase 1 (IDO1) enzyme, whose expression shared immune regulatory cells,...
Exploiting the tumor environment features (EPR effect, elevated glutathione, reactive oxygen species levels) might allow attaining a selective and responsive carrier capable of improving therapeutic outcome. To this purpose, in situ covalent binding drugs nanoparticles to circulating human serum albumin (HSA) represent pioneering approach achieve an effective strategy. This study describes synthesis, vitro vivo evaluation bioresponsive HSA-binding (MAL-PTX2S@Pba), co-delivering two different...
Hydrotalcites-like compounds, also known as anionic clays or layered double hydroxides, represent the only example of lamellar solid with positively charged layers and exchangeable interlayer anions. In this study, a nanostructured HTlc formula [Zn0.72Al0.28(OH)2] Br0.28·0.69 H2O was used inorganic drug delivery system for anticancer therapy. Two different molecules were selected being separately intercalated into ZnAl-HTlc: norcantharidin, inducing cell cycle arrest at G2/M phase,...
Triple-negative breast cancer (TNBC) is an aggressive subtype of still lacking effective treatment options. Chemotherapy in combination with immunotherapy can restrict tumor progression and repolarize the microenvironment towards anti-tumor milieu, improving clinical outcome TNBC patients. The chemotherapeutic drug paclitaxel had been shown to induce immunogenic cell death (ICD), whereas inhibitors indoleamine 2,3-dioxygenase 1 (IDO1), whose expression shared immune regulatory cells, have...