A5046660957- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photochromic and Fluorescence Chemistry
- Chemical Synthesis and Analysis
- Molecular Junctions and Nanostructures
- RNA Interference and Gene Delivery
- Dyeing and Modifying Textile Fibers
- Hydrogels: synthesis, properties, applications
- Luminescence and Fluorescent Materials
- Glycosylation and Glycoproteins Research
- Calcium Carbonate Crystallization and Inhibition
- Lipid Membrane Structure and Behavior
- Bone Tissue Engineering Materials
- Bone and Dental Protein Studies
- 2D Materials and Applications
- Skin Protection and Aging
- DNA and Nucleic Acid Chemistry
- Nanocomposite Films for Food Packaging
- Advanced Drug Delivery Systems
- Silk-based biomaterials and applications
- Flame retardant materials and properties
- Spectroscopy and Quantum Chemical Studies
- Membrane Separation and Gas Transport
University of Bologna
2018-2025
Ospedale San Giacomo Apostolo
2019-2021
Alma Mater Europaea
2021
Institute of Organic Synthesis and Photoreactivity
2016-2019
National Research Council
2016-2019
Keratin/hydrotalcites hybrid nanofibers loaded with diclofenac were proposed as a potential drug delivery system and scaffold for cells growth.
It is well assessed that the charge transport through a chiral potential barrier can result in spin-polarized charges. The possibility of driving this process visible photons holds tremendous for several aspects quantum information science, e.g., optical control and readout qubits. In context, direct observation phenomenon via spin-sensitive spectroscopies utmost importance to establish future guidelines photo-driven spin selectivity structures. Here, we provide proof time-resolved electron...
Cosmetic formulations are complex mixtures of ingredients that must fulfil several requirements. One the challenges cosmetic industries is to find natural alter-natives replace synthetic polymers, preserving desirable sensory characteristics. The aim this work induce formation gels, by replacing polymers with a low-molecular-weight gelator (LMWG), small molecule able self-assemble and form supramolecular networks. impact on environment gelators much reduced, as they highly biodegradable....
We prepared three simple molecules, that we chose as representative examples of amphiphilic and bolamphiphilic amino acid derivatives: N-lauroyl-L-phenylalanine (Lau-Phe-OH), N-palmitoyl-L-phenylalanine (Pal-Phe-OH), N,N-azeloyl-L-diphenylalanine Az-(Phe-OH)2, to study the influence aliphatic side chain on formation supramolecular materials. found Pal-Phe-OH is a very efficient gelator in contrast with Az-(Phe-OH)2 efficiently forms crystals, while Lau-Phe-OH metastable hydrogels slowly...
Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead wide variety of formulations useful for many different topical applications compatible the skin pH. An in vitro viability/cytotoxicity test gel components demonstrated that they are non-toxic, as cells continue proliferate after 48 h. analysis mechanical properties demonstrates have moderate strength an excellent linear viscoelastic range absence proper breaking point, confirmed thixotropy experiments....
Seashells are a calcium-carbonate-based material that can be converted into valuable advanced functional materials. also waste from aquaculture. They produced in millions of tonnes per year and represent an environmental issue. uniquely contain intraskeletal organic matrix rich carboxylate groups so far has not been exploited or even removed, when they were used as calcium carbonate substitutes. The allows for never reported covalent functionalization. Such process strengthens the surface...
Most supramolecular gels are stable or assumed to be over time, and aging effects often not studied.
Imines or Schiff bases (SB) are formed by the condensation of an aldehyde a ketone with primary amine, removal water molecule. central molecules in several biological processes for their ability to form and cleave small variation medium. We report here controlled hydrolysis four SBs that may be applied fragrance industry, as they profragrances all containing odorant molecules: methyl anthranilate aldehydes (cyclamal, helional, hydroxycitronellal triplal) very volatile odorants. The SB...
Photoactivatable keratin sponges were prepared from protein aqueous solutions by the freeze-drying method, followed photofunctionalization with two different photosensitizers (PS): Azure A (AzA) and 5,10,15,20-tetrakis [4-(2-N,N,N-trimethylethylthio)-2,3,5,6-tetrafluorophenyl]porphyrin tetraiodide salt (TTFAP). The have a porosity between 49% 80% mean pore size in 37-80 μm range. As compared to AzA, TTFAP interacts more strongly as demonstrated lower PS release (6% vs 20%), decreased...
Physical hydrogels are supramolecular materials obtained by self-assembly of small molecules called gelators. Aromatic amino acids and peptides containing aromatic rings good candidates as gelators due to their ability form weak bonds π-π interactions hydrogen between NH CO the peptide chain. In this paper we show our results in preparation a transparent hydrogel that was fluorine-containing dipeptide relies on additional formation halogen fluorine atoms contained dipeptide. We used...
Antioxidants are important substances used in the cosmetic and pharmaceutical fields that able to block free radicals. These compounds can be incorporated into formulations for many reasons, such as release over time or preservation of formulation activity applicability. In present study, a low-molecular-weight gel made with Boc-L-DOPA(Bn)2-OH was studied suitable material host antioxidants improve their activity. The solvent change (DMSO/H2O) combination temperature technological procedure...
Solar light-activated photocatalyst nanoparticles (NPs) are promising environment-friendly low cost tools for water decontamination, but their dispersion in the environment must be minimized. Here, we propose incorporation of TiO2-NPs (also combination with graphene platelets) into highly biocompatible hydrogels as a approach production photoactive materials treatment. We also convenient fluorescence-based method to investigate hydrogel photocatalytic activity real time conventional...
We prepared the small pseudopeptide Lau-l-Dopa(OBn)2-d-Oxd-OBn (Lau = lauric acid; l-Dopa l-3,4-dihydroxyphenylalanine; d-Oxd (4R,5S)-4-methyl-5-carboxyl-oxazolidin-2-one; Bn benzyl) through a number of coupling reactions between acid, protected and with an excellent overall yield. The ability product to form supramolecular organogels has been tested different organic solvents increasing polarity compared results obtained Fmoc-l-Dopa(OBn)2-d-Oxd-OBn. mechanical rheological properties...
Boc-L-DOPA(OBn)2-OH is a simple synthetic molecule that promotes hydrogelation through electrostatic and π-π stacking interactions. Hydrogelation can occur in alkaline conditions by the use of triggers. Four hydrogels were prepared varying base, NaOH or Na2CO3, trigger, GdL CaCl2. When hydrogel formed presence Na2CO3 CaCl2, concomitant production CaCO3 crystals occurred, generating an organic/inorganic composite material. It was observed once self-assembled preserved its status even if...
Abstract The removal of Diclofenac sodium from waste waters has a high relevance since it belongs to the therapeutic group most commonly found in wastes. An aromatic‐free and low‐impact technology that efficiently entraps aqueous pollutants is highly desirable. We synthesised two Boc‐protected tripeptides (Boc‐L‐Ala‐Aib‐L‐Val‐OH Boc‐L‐Val‐Aib‐L‐Val‐OH) studied their ability form gels with mixtures water alcohols, such as methanol, ethanol 2‐propanol. Boc‐L‐Ala‐Aib‐L‐Val‐OH forms strong...
Multicomponent supramolecular gels provide opportunities to form materials that are not accessible when using the single components alone. Different scenarios possible mixing multiple components, from complete co-assembly (mixing of within self-assembled structures formed) self-sorting such each structure contains only one components. Most examples multicomponent currently exist stable gels. Here, we show this can be used control mechanical properties gels, but what is probably most exciting...
The three gelators presented in this work (Boc-D-Phe-L-Oxd-OH F0, Boc-D-F1Phe-L-Oxd-OH F1 and Boc-D-F2Phe-L-Oxd-OH F2) share the same scaffold differ number of fluorine atoms linked to aromatic ring phenylalanine. They have been applied preparation gels 0.5% or 1.0% w/v concentration, using methodologies: solvent switch, pH change calcium ions addition. general trend is an increased tendency form structured materials from F0 F2. This property ends up formation stronger when are present. Some...
Supramolecular hydrogels, obtained from small organic molecules, may be advantageous over polymeric ones for several applications, because these materials have some peculiar properties that differentiate them the traditional such as elasticity, thixotropy, self-healing propensity, and biocompatibility. We report here preparation of strong supramolecular pseudopeptide-based hydrogels owe their strength to introduction graphene in gelling mixture. These proved strong, stable, thermoreversible...
Fragrances are volatile organic compounds widely used in our daily life. Unfortunately, the high volatility required to reach human receptors reduces their persistency air. To contrast this effect, several strategies may be used. Among them, we present here combination of two techniques: microencapsulation supramolecular gels and use profragrances. We report a study on controlled lactonization four esters derived from o-coumaric acid. The ester spontaneously occurs after exposure solar...
Over the past two decades, chirality-induced spin selectivity (CISS) effect was reported in several experiments disclosing a unique connection between chirality and electron spin. Recent theoretical works highlighted time-resolved Electron Paramagnetic Resonance (trEPR) as powerful tool to directly detect polarization resulting from CISS. Here, we report first attempt CISS at molecular level by linking pyrene donor fullerene acceptor with chiral peptide bridges of different length electric...
The ability of mussels to adhere underwater surfaces has attracted a lot attention from the scientific community. As proteins containing L‐DOPA (3,4‐dihydroxyphenyl‐ l ‐alanine) are involved in their adhesion, common strategy synthesize adhesives is incorporation this amino acid into other compounds. Herein, we report study on four compounds family Boc x ‐(L‐DOPA) n ‐OMe ( = 1–3; 1,2), that prepared through simple synthetic steps. Three them showed capability adhesion: while they not...
None to declare.