A5026303160- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Contact Dermatitis and Allergies
- Silk-based biomaterials and applications
- Cell Adhesion Molecules Research
- Dermatology and Skin Diseases
- Chemokine receptors and signaling
- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Structural Characterization
- Synthesis and properties of polymers
- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Pharmaceutical studies and practices
- Surfactants and Colloidal Systems
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Surgical Sutures and Adhesives
- Analytical Chemistry and Chromatography
- Chemical Reactions and Isotopes
- Antimicrobial Peptides and Activities
- Botulinum Toxin and Related Neurological Disorders
University of Milan
2016-2025
Mylan (South Africa)
2019
Ospedale San Pietro Fatebenefratelli
2010
Context: The selection of a proper taste-masking agent (TMA) is critical issue in the development fast‐dissolving films containing bitter drugs. Objective: This work aimed to evaluate suppression taste maltodextrin fast-dissolving film loaded with 13.4 mg sodium diclofenac (DS) by adding TMAs. Methods: were prepared casting and drying aqueous mixtures (DE = 6), glycerin, sorbitan oleate, DS. Films characterized terms thickness, tensile properties, disintegration time, drug dissolution time....
Keratin/hydrotalcites hybrid nanofibers loaded with diclofenac were proposed as a potential drug delivery system and scaffold for cells growth.
This work aims to elucidate the mechanism by which N-methylpyrrolidone (NMP) enhances skin permeation of a compound combining experimental data with molecular dynamic (MD) simulations. The addition 10% NMP significantly increased propranolol (PR) through human epidermis (∼15 μg/cm2 vs ∼30 μg/cm2) while resulting inefficacious on hydrocortisone (HC) diffusion. No significant alterations in stratum corneum structure were found after vitro treatment dispersed mineral oil or water attenuated...
Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit® E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) plasticizers tributylcitrate, glycerine, triacetin PEG 400). Methods: physicochemical mechanical properties the FFS dried films were evaluated terms formation time, stickiness, Tg, tensile strength, break elongation Young’s modulus. vitro skin permeation studies conducted...
This study aimed to identify a new skin penetrating peptide (SPP) able enhance unfractionated heparin (UFH) permeation through human epidermis by screening phage display library. The effects of the synthesized heptapeptide (DRTTLTN) on stratum corneum organization were investigated ATR-FTIR spectroscopy and molecular dynamics simulation. DRTTLTN penetration within caused both fluidization lipids extension keratins due increase contribution α-helices. coadministration with UFH resulted...
This work aimed to investigate the feasibility design: (a) a mucoadhesive interpolyelectrolyte complex (IPEC) loaded with clobetasol propionate (CP) intended treat oral lichen planus and (b) individuate an orodispersible dosage form suitable for its administration. IPECs were synthesized by mixing Eudragit® E PO (EPO) different grades of cross-linked polyacrylate derivatives, in molar ratios, namely 1:1, 1:2, 2:1. All resulted at nanoscale independently their composition (120⁻200 nm). Both...
Eosinophilic esophagitis (EE) is a chronic immune/antigen-mediated esophageal inflammatory disease for which off-label topical corticosteroids (e.g., budesonide) are widely used in clinic. In general, thickening excipients mixed with industrial products to improve the residence time of drug on mucosa. The compounding procedures empirical and composition not supported by real physicochemical technological characterization. current study aimed propose standardized budesonide oral formulation...
The literature data suggest the capacity of biomacromolecules to permeate human skin, even though such a transdermal permeation appears be governed by physicochemical parameters which are significantly different compared those ruling skin small molecules. On these grounds, present study was undertaken investigate in vitro diffusion properties through epidermis hyaluronic acid and their sulfates. Low- medium-molecular-weight acids corresponding derivatives at two degrees sulfation were then...
The aim of this study is to compare three different dissolution methods assess the drug release from oral lyophilisates, based on interpolyelectrolyte complexes (IPECs). IPECs were prepared by mixing solutions a linear polymer, Eudragit® EPO, with polymer cross-linked structure, Noveon® AA-1 or Carbopol® 10 Ultrez (in ratios 1:2 and 1:1, respectively). Metformin metronidazole used as model drugs achieve systemic local effect. A comparative assessment kinetics was carried out using artificial...
The data presented in this article are an update of the dataset provided by Musazzi et al. [1] and related to research entitled "Equivalence assessment creams with quali-quantitative differences light EMA FDA regulatory framework" [2]. In vitro permeation study (IVPT) is typically conducted using method Franz's diffusion cell for assessing biopharmaceutical performance topically applied products. While human epidermis considered benchmark, various animal models (for instance, pig ear) have...
To evaluate the feasibility of a transdermal patch containing propranolol (PR).Skin penetration enhancers (SPEs) able to improve skin permeability PR were selected and quality by design approach was applied development 2(4) full factorial design. The permeation profile from formulations assessed in vitro studies performed using Franz diffusion cells human epidermis as membrane. Finally, irritation evaluated Draize test.N-methyl pyrrolidone (NMP) resulted best SPE: addition, critical factors...