A5032519390- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Pharmacological Receptor Mechanisms and Effects
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Prostate Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Cancer Cells and Metastasis
- Mathematical Biology Tumor Growth
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Receptor Mechanisms and Signaling
- Nonmelanoma Skin Cancer Studies
- Peptidase Inhibition and Analysis
- Head and Neck Cancer Studies
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
GNA University
2024
Azienda USL di Bologna
2023
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2014-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2022
University of Bologna
2018-2019
Policlinico S.Orsola-Malpighi
2018-2019
March of Dimes
2018
The potential of a spheroid tumor model composed cells in different proliferative and metabolic states for the development new anticancer strategies has been amply demonstrated. However, there is little or no information literature on problems reproducibility data originating from experiments using 3D models. Our analyses, carried out novel open source software capable performing an automatic image analysis colonies, showed that number morphology parameters affect response large spheroids to...
Abstract Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or acquired property prostate cells over-activate signaling pathways. Tumor microenvironment plays a critical role progression. However, mechanism involving androgen/androgen associated fibroblasts consequences for progression still remains elusive. We...
Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with temozolomide standard treatment, but nevertheless, relapse occurs nearly all cases. Understanding mechanisms underlying radiation resistance may help to find more effective therapies. After ATP released into microenvironment where it binds and activates purinergic P2 receptors, mainly of P2X7 subtype. Two main splice variants, P2X7A P2X7B, are expressed cell types, they associate distinct biochemical...
The androgen receptor (AR) represents the primary target for prostate cancer (PC) treatment even when disease progresses toward androgen-independent (AIPC) or castration-resistant (CRPC) forms. Because small chemical changes in structure of nonsteroidal AR ligands determine pharmacological responses AR, we developed a novel stereoselective synthetic strategy that allows sterically hindered C2-substituted bicalutamide analogues to be obtained. Biological and theoretical evaluations...
Prostate cancer (PC) is the fifth leading cause of death in men, and androgen receptor (AR) represents primary target for PC treatment, even though disease frequently progresses toward androgen-independent forms. Most commercially available nonsteroidal antiandrogens show a common scaffold consisting two aromatic rings connected by linear or cyclic spacer. By taking advantage facile, one-pot click chemistry reaction, we report herein preparation small library novel 1,4-substituted triazoles...
Abstract Background Recent developments in abscopal effect strongly support the use of radiotherapy for treatment metastatic disease. However, deeper understanding molecular mechanisms underlying are required to best benefit a larger proportion patients with metastasis. Several groups including ours, reported involvement wild-type (wt) p53 radiation-induced effects, however very little is known on role wtp53 dependent mechanisms. Methods We investigated through vivo and vitro approaches how...
Cisplatin‑pemetrexed is a frequently adopted first‑line treatment for patients with advanced non‑small cell lung cancer (NSCLC) ineligible biological therapy, notwithstanding its limited efficacy. In the present study, RAL line, an epidermal growth factor receptor (EGFR)‑wild‑type, p53‑ and KRAS‑mutated model of NSCLC, was used to investigate novel biomarkers resistance this treatment. Cells were analyzed 96 h (96 h‑post wo) 21 days (21 d‑post after combined washout. Following initial...
Human glioblastoma (GBM) is one of the most feared primary malignant brain tumors. We investigated effect hyperbaric oxygen (HBO) on GBM patient-derived cells and microglia cell biology (CHME-5). HBO administered to inhibited proliferation, downregulated hypoxia-inducible factor 1 α (HIF-1α) expression, induced glucose metabolism reprogramming (glucose rewiring). It also affected ability a perpetuate its lineage, give rise differentiated interact with environment maintain balance between...
Pancreatic cancer (PC) remains one of the most lethal cancers worldwide. Sigma receptors (SRs) have been proposed as therapeutic targets. Their main localization suggests they play a potential role in ER stress and triggering unfolded protein response (UPR). Here, we investigated mechanisms action RC-106, novel pan-SR modulator, to characterize therapeutically exploitable SRs tumors. Two PC cell lines were used all experiments. Terminal UPR activation was evaluated by quantifying BiP, ATF4...
A Correction to this paper has been published: https://doi.org/10.1038/s41419-021-03483-4
Abstract Background. Recent developments in abscopal effect strongly support the use of radiotherapy for treatment metastatic disease. However, deeper understanding molecular mechanisms underlying are required to best benefit a larger proportion patients with metastasis. Several groups including ours, reported involvement wild-type (wt) p53 radiation-induced effects, however very little is known on role wtp53 dependent mechanisms. Methods . We investigated through vivo and vitro approaches...
The past two decades have seen a shift from cytotoxic drugs to targeted therapy in medical oncology. Although therapeutic agents shown more impressive clinical efficacy and minimized adverse effects than traditional treatments, drug resistance has become the main limitation their benefits. Several preclinical vitro/in vivo models of acquired practice been developed mainly by using strategies: i) genetic manipulation for modeling genotypes resistance, ii) selection resistant models. In...