A5064363902- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Hormonal and reproductive studies
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Genomics and Chromatin Dynamics
- Ion Channels and Receptors
- FOXO transcription factor regulation
- Prostate Cancer Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Carcinogens and Genotoxicity Assessment
- Steroid Chemistry and Biochemistry
- Chemical Synthesis and Analysis
- Cancer, Lipids, and Metabolism
- Advanced Breast Cancer Therapies
- Peptidase Inhibition and Analysis
- Reproductive System and Pregnancy
- Effects and risks of endocrine disrupting chemicals
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
University of Campania "Luigi Vanvitelli"
2013-2024
University of Naples Federico II
2007-2016
Magna Graecia University
2016
University of Turin
2016
University of Palermo
2016
University of Salerno
2016
Abstract Breast cancer (BC) is still characterized by high morbidity and mortality. A specific BC subtype named triple negative (TNBC) lacks estrogen progesterone receptors (ER PR, respectively) the absence of overexpression/amplification human epidermal growth factor receptor 2 (HER2). The androgen (AR) expressed in TNBC, although its function these cancers debated. Moreover, few therapeutic options are currently available for treatment TNBC. In this study, we have used TNBC-derived...
Abstract Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or acquired property prostate cells over-activate signaling pathways. Tumor microenvironment plays a critical role progression. However, mechanism involving androgen/androgen associated fibroblasts consequences for progression still remains elusive. We...
Background Androgen receptor (AR) controls male morphogenesis, gametogenesis and prostate growth as well development of cancer. These findings support a role for AR in cell migration invasiveness. However, the molecular mechanism involved AR-mediated still remains elusive. Methodology/Principal Findings Mouse embryo NIH3T3 fibroblasts highly metastatic human fibrosarcoma HT1080 cells harbor low levels transcriptionally incompetent AR. We now report that, through extra nuclear action,...
Abstract This report offers direct evidence that association of the estradiol receptor (ER) with Src triggered by steroid agonists or growth factors controls breast and prostate cancer cell growth. is abolished in whole cells vitro a six-amino-acid peptide mimics sequence around phosphotyrosine residue position 537 human ERα. The phosphorylated peptide, at nanomolar concentrations, taken up MCF-7 LNCaP derived from mammary cancers, respectively. In addition, to block ER/Src interaction,...
Bisphenol A (BPA) belongs to the class of chemicals known as endocrine disruptors and has been also involved in pathogenesis progression related cancer such breast prostate cancers. Here, we have investigated effect BPA human LNCaP cells non-transformed epithelial EPN cells. Our data showed that induces down regulation cyclin D1 expression upregulation cell cycle inhibitors p21 p27, leading arrest. Interestingly, found anti-proliferative response depends on a strong rapid activation...
The functions of androgen receptor (AR) in stromal cells are still debated spite the demonstrated importance these organ development and diseases. Here, we show that physiological concentration (10 nM R1881 or DHT) fails to induce DNA synthesis, while it consistently stimulates cell migration mesenchymal transformed cells. Ten nanomolar triggers p27 Ser10 phosphorylation its stabilization NIH3T3 fibroblasts. Activation Rac downstream effector DYRK 1B is responsible for quiescence. also...
Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear. Here, we have characterized and investigated the effects TRPM8 modulators cancer aggressiveness disclosing molecular underlying their biological activity. Patch-clamp calcium fluorometric assays were used to characterize synthesized compounds. Androgen-stimulated cancer-derived cells challenged with compounds DNA synthesis was a preliminary...
Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive the disease’s aggressiveness and pharmacological response, challenge for more tailored approach in clinical management patients. Nerve growth factor, initially identified as key factor neuronal survival differentiation, turned out to be multifaceted molecule with pleiotropic effects quite divergent cell types, including cells. Many solid...
Breast cancer is a heterogeneous disease that represents the most common around world; it comprises 12% of new cases according to World Health Organization. Despite approaches in early diagnosis and current treatment, breast still leading cause death for mortality. New targeted therapies against key signalling transduction molecules are required. Phosphoinositide 3-kinase (PI3K) regulates multiple biological functions such as proliferation, survival, migration, growth. It well established...