A5025434991- Hemoglobin structure and function
- Protein Interaction Studies and Fluorescence Analysis
- Per- and polyfluoroalkyl substances research
- Lipoproteins and Cardiovascular Health
- Analytical Chemistry and Sensors
- Helicobacter pylori-related gastroenterology studies
- Bone and Dental Protein Studies
- Electrochemical sensors and biosensors
- Microbial metabolism and enzyme function
- Reproductive tract infections research
- Folate and B Vitamins Research
- Molecular spectroscopy and chirality
- Spectroscopy and Laser Applications
- Sexual function and dysfunction studies
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
- Toxic Organic Pollutants Impact
- Urinary Tract Infections Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Periodontal Regeneration and Treatments
- Protease and Inhibitor Mechanisms
University of Pavia
2024
University of Padua
2021-2022
Ca' Foscari University of Venice
2020-2021
The Royal Free Hospital
2004
State Hospital
2004
University College London
2004
General Hospital of Attica
1999
The determination of per- and polyfluoroalkyl substances (PFAS) in environmental samples, such as drinking waters, requires the design high performing versatile sensing strategies. Label-free biosensing platforms based on specialty fiber optics are a valid option to face this challenge. Among them, lossy mode resonance (LMR) optic biosensors showing remarkable performance terms detection limit, selectivity, reproducibility. small molecules, perfluorooctanoic acid (PFOA), can be achieved with...
The current trend dealing with the production of per- and polyfluoroalkyl substances (PFASs) involves shifting toward branched short-chain fluorinated compounds known as new-generation PFASs. A key aspect to be clarified, address adverse health effects associated exposure PFASs, is their binding mode human serum albumin (hSA), most abundant protein in plasma. In this study, we investigated interaction between hSA two representative namely, HPFO-DA C6O4. In-solution studies revealed that both...
Abstract Perfluorooctanoic acid (PFOA) is a toxic compound that absorbed and distributed throughout the body by noncovalent binding to serum proteins such as human albumin (hSA). Though interaction between PFOA hSA has been already assessed using various analytical techniques, high resolution detailed analysis of mode still lacking. We report here crystal structure in complex with medium‐chain saturated fatty (FA). A total eight distinct sites, four occupied PFOAs FAs, have identified. In...
Gemfibrozil (GEM) is an orally administered lipid-regulating fibrate derivative drug sold under the brand name Lopid®, among others. Since its approval in early 80s, GEM has been largely applied to treat hypertriglyceridemia and other disorders of lipid metabolism. Though generally well tolerated, can alter distribution free, active concentration some co-administered drugs, leading adverse effects. Most them appear be related ability bind with high affinity human serum albumin (HSA), major...
Familial hypercholesterolaemia (FH) is associated with premature coronary heart disease (CHD). Post-prandial hypertriglyceridaemia has also been cardiovascular disease. Thus, an abnormal post-prandial triglyceride (TG) clearance may contribute to the heterogeneity in risk of CHD heterozygous (h) FH. Therefore, we investigated response TG levels a fatty meal men hFH. We studied 26 Greek divided into two groups: hFH group 14 men, mean age 39 (SD = 11) years and control 12 healthy 43 (50:5)...
ABSTRACT During biosynthesis, collagen lysine residues undergo extensive post-translational modifications essential for the stability and functions of supramolecular assemblies. In endoplasmic reticulum, two distinct metal ion dependent enzyme families (i.e., multifunctional lysyl hydroxylases-glucosyltransferases LH/PLODs galactosyltransferases GLT25D/COLGALT) alternatively operate on side chains ultimately generating highly conserved α-(1,2)-glucosyl-β-(1,O)-galactosyl-5-hydroxylysine...