A5033107853- interferon and immune responses
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Antimicrobial Resistance in Staphylococcus
- Cancer-related molecular mechanisms research
- Bacterial Identification and Susceptibility Testing
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Clostridium difficile and Clostridium perfringens research
- MicroRNA in disease regulation
- Spaceflight effects on biology
- Whipple's Disease and Interleukins
- HIV Research and Treatment
- Circular RNAs in diseases
- vaccines and immunoinformatics approaches
- Immunotoxicology and immune responses
- Bacterial biofilms and quorum sensing
- RNA regulation and disease
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Antimicrobial Peptides and Activities
- Cellular Mechanics and Interactions
- Autophagy in Disease and Therapy
- Tuberculosis Research and Epidemiology
Institut Pasteur
2020-2022
Istituto Superiore di Sanità
2015-2021
Toxicologie, Pharmacologie et Signalisation Cellulaire
2021
Inserm
2020
Roma Tre University
2017
Weatherford College
2015
Autophagy is a primordial eukaryotic pathway, which provides the immune system with multiple mechanisms for elimination of invading pathogens including Mycobacterium tuberculosis (Mtb). As consequence, Mtb has evolved different strategies to hijack autophagy process. Given crucial role human primary dendritic cells (DC) in host immunity control, we characterized Mtb-DC interplay by studying contribution cellular microRNAs (miRNAs) post-transcriptional regulation related genes. From...
Background: B cells are key pathogenic effectors in multiple sclerosis (MS) and several therapies have been designed to restrain cell abnormalities by directly targeting this lymphocyte population. Objectives: Moving from our data showing a Toll-like receptor (TLR)7-driven dysregulation of response relapsing–remitting (RRMS) having found low serum level Thymosin-α1 (Tα1) patients, we investigated whether the addition molecule peripheral blood mononuclear (PBMCs) would influence expansion...
The opportunistic pathogen Staphylococcus aureus (S. aureus) is a major cause of nosocomial- and community-acquired infections. In addition, many antibiotic-resistant strains are emerging worldwide, thus, there an urgent unmet need to pinpoint novel therapeutic prophylactic strategies. the present study, we characterized impact infection with pandemic methicillin-resistant USA300 S. strain on human primary dendritic cells (DC), key initiators regulators immune responses. particular, among...
Modern strategies to develop vaccines against Mycobacterium tuberculosis (Mtb) aim improve the current Bacillus Calmette-Guerin (BCG) vaccine or attenuate virulence of Mtb candidates. In present study, impact wild type mutated region difference 1 (RD1) variants on immunogenicity and BCG recombinants was investigated in human primary dendritic cells (DC). A comparative analysis transcriptome, signalling pathway activation, maturation, apoptosis, cytokine production capacity promote Th1...
Objectives: Thymosin α 1 (Tα1) recently gained interest as immune adjuvant for vaccines because of its ability to modulate the T-cell/dendritic cell (DC) axis and improve antibody production. The objective this study was determine whether Tα1 would address in vitro response human primary monocyte-derived DC, crucial regulators vaccine-induced immunity, upon exposure different toll-like receptor (TLR) agonists or infection with viruses bacteria.
Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation downstream JAK/STAT pathway. In any given cell type, level USP18 is a key determinant output IFN-stimulated transcripts. How baseline finely tuned in different types remains ill defined. Here, we identified microRNAs (miRNAs) that efficiently target through 3’untranslated region (3’UTR). Among these, three miRNAs are...
Regulation of innate immune responses is essential for maintenance homeostasis and development an appropriate immunity against microbial infection. We show here that miR-3614-5p , product the TRIM25 host gene, induced by type I interferon (IFN-I) in several human non-immune cell types, particular primary myeloid cells. Studies HeLa cells showed represses both p110 p150 ADAR1 reduces constitutive IFN-induced A-to-I RNA editing. In line with this, activation sensors expression IFN-β...
Journal Article Teicoplanin in the treatment of infections by staphylococci, Clostridium difficile and other Gram-positive bacteria Get access F. de LaDa, LaDa Corresponding author: Fausto Lalla, Divisone Malattie Infettive Ospedale S. Anna, Via Napoleona 60, 22100 Como, Italy Search for works this author on: Oxford Academic PubMed Google Scholar D. Santoro, Santoro E. Rinaldi, Rinaldi Suter, Suter aDepartment Infectious Diseases, Busto Arsizio General HospitalBusto Arsizio, Milan M....
Understanding Staphylococcus aureus (S. aureus)-host immune system interaction is crucial to meet the tremendous medical need associated with this life-threatening bacterial infection. Given role of dendritic cells (DC) in dictating responses upon microbial challenge, we investigated how viability and conservation structural integrity influence response human DC S. aureus. To end, primary were stimulated methicillin-resistant USA300 live strain, inactivated by heat (HI), ultraviolet...
In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the block induced by Mycobacterium tuberculosis (Mtb) promotes a Th1 response via IL-12 secretion. Here, immunostimulatory activity of rapamycin in Mtb-infected DC was further investigated analyzing both transcriptome translatome gene profiles. Hundreds differentially expressed genes (DEGs) were identified analyses DC, some these found modulated rapamycin. The majority...
ABSTRACT Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation downstream JAK/STAT pathway. In any given cell type, level USP18 is a key determinant output interferon-stimulated transcripts. How baseline finely tuned in different types remains ill defined. Here we explored post-transcriptional regulation microRNAs (miRNAs) identified four miRNAs ( miR-24-3p, miR-191-5p,...