A5001875128- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Hidradenitis Suppurativa and Treatments
- Acne and Rosacea Treatments and Effects
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Sarcoma Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
Institut de Biologie Moléculaire et Cellulaire
2022-2024
Institut Polytechnique de Bordeaux
2022
Centre National de la Recherche Scientifique
2022
Immunologie, Immunopathologie et Chimie Thérapeutique
2022
Université de Strasbourg
2022
Abstract Osteosarcoma (OS) is the most common primary bone cancer, where overall 5‐year surviving rate below 20% in resistant forms. Accelerating cures for those poor outcome patients remains a challenge. Nevertheless, several studies of agents targeting abnormal cancerous pathways have yielded disappointing results when translated into clinic because lack accurate OS preclinical modeling. So, any effort to design drug testing may consider all inter‐, intra‐, and extra‐tumoral...
Abstract Hidradenitis suppurativa (HS) is a recurrent inflammatory skin disease with complex etiopathogenesis whose treatment poses challenge in the clinical practice. Here, we present novel integrated pipeline produced by European consortium BATMAN (Biomolecular Analysis for Tailored Medicine Acne iNversa) aimed at investigating molecular pathways involved HS developing new diagnosis algorithms and building cellular models to pave way personalized treatments. The objectives of our european...
Macroautophagy (often-named autophagy), a catabolic process involving autophagy-related (Atg) genes, prevents the accumulation of harmful cytoplasmic components and mobilizes energy reserves in long-lived self-renewing cells. Autophagy deficiency affects antigen presentation conventional dendritic cells (DCs) without impacting their survival. However, previous studies did not address epidermal Langerhans (LCs). Here, we demonstrate that deletion either Atg5 or Atg7 LCs leads to gradual...
ABSTRACT Macroautophagy (often-named autophagy), a catabolic process involving autophagy-related ( Atg ) genes, prevents accumulation of harmful cytoplasmic components and mobilizes energy reserves in long-lived self-renewing cells. Autophagy deficiency affects antigen presentation conventional dendritic cells (DCs) without impacting their survival. However, previous studies did not address epidermal Langerhans (LCs). Here, we demonstrate that deletion either Atg5 or Atg7 LCs leads to...