A5101493282- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Medicinal Plants and Bioactive Compounds
- Reproductive tract infections research
- Plant-based Medicinal Research
- Flowering Plant Growth and Cultivation
- Biological and pharmacological studies of plants
- Herbal Medicine Research Studies
- Virology and Viral Diseases
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Viral Infections and Outbreaks Research
- Cancer-related Molecular Pathways
- Nail Diseases and Treatments
- Circular RNAs in diseases
- Complementary and Alternative Medicine Studies
- Herpesvirus Infections and Treatments
- Genomics and Chromatin Dynamics
- Plant tissue culture and regeneration
Chhatrapati Shahu Ji Maharaj University
2022
Monash University Malaysia
2018
Heidelberg University
2014-2017
German Cancer Research Center
2014-2017
DKFZ-ZMBH Alliance
2014-2015
Defence Institute of Physiology and Allied Sciences
2009
Tamoxifen is an endocrine therapy which administered to up 70% of all breast cancer patients with oestrogen receptor alpha (ERα) expression. Despite the initial response, most eventually acquire resistance drug. MicroRNAs (miRNAs) are a class small non-coding RNAs have ability post-transcriptionally regulate genes. Although role few miRNAs has been described in tamoxifen at single gene/target level, little known about how concerted actions targeting biological networks contribute resistance....
Amplified HER2, which encodes a member of the epidermal growth factor receptor (EGFR) family, is target effective therapies against breast cancer. In search for similarly targetable genomic aberrations, we identified copy number gains in SYNJ2, 5'-inositol lipid phosphatase synaptojanin 2, as well overexpression small fraction human tumors. Copy gain and correlated with shorter patient survival low abundance tumor suppressor microRNA miR-31. SYNJ2 promoted cell migration invasion culture...
Crosstalk between growth factors (GFs) and steroid hormones recurs in embryogenesis is co-opted pathology, but underlying mechanisms remain elusive. Our data from mammary cells imply that the crosstalk epidermal GF glucocorticoids (GCs) involves transcription like p53 NF-κB, along with reduced pausing traveling of RNA polymerase II (RNAPII) at both promoters bodies GF-inducible genes. Essentially, GCs inhibit positive feedback loops activated by GFs stimulate reciprocal inhibitory loops. As...
In the present study we have evaluated immunopotentiating activity of Rhodiola aqueous extract (RAE) in rats. The efficacy RAE was determined by using strong antigen tetanus toxoid (TT) and weak Ovalbumin (OVA). dynamic changes humoral cell-mediated immune response were measured. results indicated that TT specific immunoglobulin levels significantly enhanced at par with complete Freund's adjuvant (CFA). level OVA induced antibody also RAE. It observed combination CFA or could evoke a...
In the present study we have evaluated immunopotentiating activity of Rhodiola aqueous extract (RAE) in rats. The efficacy RAE was determined by using strong antigen tetanus toxoid (TT) and weak Ovalbumin (OVA). dynamic changes humoral cell-mediated immune response were measured. results indicated that TT specific immunoglobulin levels significantly enhanced at par with complete Freund’s adjuvant (CFA). level OVA induced antibody also RAE. It observed combination CFA or could evoke a...
This study was undertaken to evaluate the performance of cut Dendrobium pink sunshine under various holding solutions at post graduate lab Department Horticulture, Faculty Agriculture, Annamalai University, Tamil Nadu, India, during February 2016. The treatments with three replications were carried out in completely randomized design 3 spikes each replication. Nine chemical preservative used for extending vase life and are T1 8-HQC (200-ppm), T2 Citric Acid T3 STS T4 GA T5 Al2 (SO4)3...
Abstract microRNAs (miRNAs) sind kleine, nicht für Proteine codierende RNAs, die wichtige biologische Prozesse regulieren. Neben Funktionen in der natürlichen Entwicklung von Lebewesen auch Beteiligungen an Kranksheitsprozessen wie Krebs beschrieben worden. Diese Regulation erfolgt durch Basenpaarung mit mRNAs Zielgenen, und führt entweder zu deren Abbau oder einer Blockade Herstellung diesen codierten Proteinen. Da innerhalb miRNAs nur eine sehr kurze, etwa 6‐7 Nukleotide lange...