A5021708646- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Aortic Disease and Treatment Approaches
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Aortic aneurysm repair treatments
- Nitric Oxide and Endothelin Effects
- Polyamine Metabolism and Applications
- Sepsis Diagnosis and Treatment
- Patient-Provider Communication in Healthcare
- Artificial Intelligence in Healthcare and Education
- Thermal Regulation in Medicine
- Neuroscience and Neuropharmacology Research
- Migraine and Headache Studies
- Kawasaki Disease and Coronary Complications
- Optical Imaging and Spectroscopy Techniques
- Frailty in Older Adults
- Bacterial Infections and Vaccines
- Eicosanoids and Hypertension Pharmacology
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2008-2025
Amsterdam UMC Location University of Amsterdam
2013-2025
Amsterdam Neuroscience
2019-2024
University Medical Center Utrecht
2009-2022
Utrecht University
2022
Radboud University Medical Center
2016
Radboud University Nijmegen
2016
University Medical Center
2016
Medisch Centrum Haaglanden
2015
Induced hypertension is widely used to treat delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but a literature review shows that its presumed effectiveness based on uncontrolled case-series only. We here report clinical outcome of hemorrhage patients with DCI included in randomized trial the induced hypertension.Aneurysmal symptoms were or no hypertension. Risk ratios for poor (modified Rankin Scale score >3) at 3 months, 95% confidence intervals, calculated and...
Recently, two randomized controlled phase II studies showed that acute initiation of statin treatment directly after aneurysmal subarachnoid hemorrhage (SAH) decreases the incidence radiologic vasospasm and clinical signs delayed cerebral ischemia (DCI), even reduces mortality. It was hypothesized beneficial effect resulted from pleiotropic effects statins. The purpose this study to investigate biologic in patients with SAH. We performed an exploratory single-center, prospective, randomized,...
Decompressive neurosurgery is recommended for patients with cerebral venous thrombosis (CVT) who have large parenchymal lesions and impending brain herniation. This recommendation based on limited evidence. We report long-term outcomes of CVT treated by decompressive in an international cohort.
Patients with fusiform aneurysms can present subarachnoid hemorrhage (SAH), mass effect, ischemia, or unrelated symptoms. The absence of an aneurysm neck impedes the direct application a clip and endovascular coil deployment. To evaluate effects their treatments, authors retrospectively analyzed consecutive series patients posterior circulation treated at Stanford University Medical Center between 1991 2005.Forty-nine (mean age 53 years, male/female ratio 1.2:1) authors' medical center form...
The presumed effectiveness of induced hypertension for treating delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage is based on uncontrolled case-series only. We assessed the effect blood flow (CBF) in patients with a randomized clinical trial.Aneurysmal were to or no (control group) at onset. CBF was assessed, blinded treatment allocation, computed tomographic perfusion standardized predefined regions onset and 24 36 hours study treatment. Mean arterial pressure compared...
Abstract Background A frequent complication in patients with subarachnoid hemorrhage (SAH) is recurrent bleeding from the aneurysm. The risk highest within first 6 hours after initial hemorrhage. Securing aneurysm this timeframe difficult owing to logistical delays. rate of can also be reduced by ultra-early administration antifibrinolytics, which probably improves functional outcome. aim study investigate whether and short-term antifibrinolytic agent tranexamic acid (TXA), as add-on...
Background and Purpose— Delayed cerebral ischemia (DCI) is an important cause of poor outcome after aneurysmal subarachnoid hemorrhage. If clinical signs DCI occur, induced hypertension a plausible but unproven therapeutic intervention. There equipoise if the use induction useful or not with consequence that this strategy irregularly used. We explored effect blood pressure augmentation in preventing infarction patients DCI. Methods— performed retrospective observational study, totaling 1647...
Abstract Objective To prevent complications following decompressive craniectomy (DC), such as sinking skin flap syndrome, studies suggested early cranioplasty (CP). However, several groups reported higher complication rates in CP. We studied the clinical characteristics associated with patients undergoing CP, special emphasis on timing. Methods A single-center observational cohort study was performed, including all CP from 2006 to 2018, identify predictors of complications. Results 145...
Small retrospective case series suggest that decompressive hemicraniectomy can be life saving in patients with cerebral venous thrombosis (CVT) and impending brain herniation. Prospective studies of consecutive cases are lacking. Thus, a single centre, prospective study was performed. In 2006 we adapted our protocol for CVT treatment to perform acute herniation, whom the prognosis conservative considered infaust. We included all between 2010 who underwent hemicraniectomy. Outcome assessed at...
OBJECTIVES: To perform a detailed examination of sodium levels, hyponatremia and fluctuations, their association with delayed cerebral ischemia (DCI) poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). DESIGN: An observational cohort study from prospective SAH Registry. SETTING: Tertiary referral center focused on treatment in the Amsterdam metropolitan area. PATIENTS: A total 964 adult patients confirmed aSAH were included between 2011 2021. INTERVENTIONS: None. MEASUREMENTS AND...
The results of the ULTRA trial showed that ultra-early and short-term treatment with tranexamic acid (TXA) does not improve clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH). Possibly, lack a beneficial effect in all patients aSAH is masked by antagonistic effects TXA certain subgroups. In this post hoc subgroup analysis, we investigated on good-grade poor-grade aSAH.
ABSTRACT Background and Aims Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune‐mediated disorder characterized by peripheral nerve damage. Although T lymphocytes (T‐cells) are implicated in the pathogenesis of CIDP, we previously observed that frequency highly expanded T‐cell clones (HECs) blood CIDP patients was not different from healthy controls. To investigate if local T‐cells might be pathogenic, employed next‐generation sequencing to compare TCRβ repertoire between...
Decompressive craniectomy (DC) can be lifesaving, but many survivors do not regain independence in daily life. Recovery of consciousness the first post-operative days is regarded as a prognostic factor, however, literature on relation between early recovery and long-term scarce. To analyse 14 post-DC functional outcome. Glasgow Coma Scale (GCS) motor (M) scores during 188 consecutive adult patients undergoing DC for various pathologies were retrospectively extracted from hospital records,...
Background Anticoagulation is the mainstay acute therapy for cerebral venous thrombosis (CVT). Decompressive surgery required in a small minority of patients with large parenchymal lesions and impending herniation, which requires temporary suspension anticoagulation. Aims The objective this study was to identify optimal timing starting or resuming anticoagulation following decompressive surgery. Methods Data were collected from Surgery CVT Study 2 (DECOMPRESS2), prospective multinational...
Abstract Background and objectives The modified Rankin Scale (mRS) is one of the most frequently used outcome measures in trials patients with an aneurysmal subarachnoid hemorrhage (aSAH). assessment method mRS often not clearly described trials, while might influence score. aim this study to evaluate inter-method reliability different methods mRS. Methods This a prospective, randomized, multicenter follow-up at 6 weeks months. Patients aged ≥ 18 years aSAH were randomized either structured...
<h3>BACKGROUND AND PURPOSE:</h3> Endovascular treatment has been increasingly used for anterior cranial fossa dural AVFs. Evidence on the safety and efficacy of different endovascular strategies is limited. We report clinical angiographic outcomes patients with AVFs who underwent using transarterial embolization <i>n-</i>BCA as a first-line approach. <h3>MATERIALS METHODS:</h3> Consecutive undergoing at Amsterdam University Medical Centers between 2010 2023 were retrospectively included....
BACKGROUND AND OBJECTIVES: Treatment of patients who present with poor clinical condition is often postponed until neurological improvement observed. Despite previous studies, it still unclear how survivors perceive their quality life (QoL). This study aimed to evaluate self-perceived QoL in aneurysmal subarachnoid hemorrhage condition, as defined by World Federation Neurosurgical Societies (WFNS) grades 4 5, compared those more favorable (WFNS 1-3). METHODS: Between 2011 and 2021, 1160 were...