A5058631092- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- S100 Proteins and Annexins
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Cerebrospinal fluid and hydrocephalus
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Family and Patient Care in Intensive Care Units
- Tracheal and airway disorders
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury Research
- Neurological Disorders and Treatments
University of Salento
2024-2025
University of Bologna
2010-2023
King's College London
2023
University of Turin
2009-2020
Sapienza University of Rome
2016-2020
Policlinico Umberto I
2015-2017
Medico
2016
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2014
Marymount University
2013
CSI Piemonte
2013
Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly nonaerated compartments that may be hyperinflated by tidal inflation.We hypothesized despite limitation, patients with larger are exposed to hyperinflation compartment.Pulmonary computed at end-expiration end-inspiration was obtained 30 ventilated low (6 ml/kg predicted body weight). Cluster...
Background Tidal hyperinflation may occur in patients with acute respiratory distress syndrome who are ventilated a tidal volume (VT) of 6 ml/kg predicted body weight develop plateau pressure (PPLAT) 28 < or = PPLAT 30 cm H2O. The authors verified whether VT lower than enhance lung protection and that consequent acidosis be managed by extracorporeal carbon dioxide removal. Methods PPLAT, morphology computed tomography, pulmonary inflammatory cytokines (bronchoalveolar lavage) were...
Tracheotomy is used to replace endotracheal intubation in patients requiring prolonged ventilation; however, there considerable variability the time considered optimal for performing tracheotomy. This of clinical importance because timing a key criterion tracheotomy and who receive one require large amount health care resources.To determine effectiveness early (after 6-8 days laryngeal intubation) compared with late 13-15 reducing incidence pneumonia increasing number ventilator-free...
A lung-protective ventilatory strategy with low tidal volume (VT) has been proposed for use in acute respiratory distress syndrome (ARDS). Alveolar derecruitment may occur during the of a and be prevented by recruiting maneuvers. This study examined hypothesis that effectiveness maneuver to improve oxygenation patients ARDS would influenced elastic properties lung chest wall.Twenty-two were studied ARDSNet strategy: VT was set at 6 ml/kg predicted body weight positive end-expiratory pressure...
Many potential donor lungs deteriorate between the time of brain death and evaluation for transplantation suitability, possibly because ventilatory strategy used after death.To test whether a lung protective increases number available transplantation.Multicenter randomized controlled trial patients with beating hearts who were organ donors conducted at 12 European intensive care units from September 2004 to May 2009 in Protective Ventilatory Strategy Potential Lung Donors Study....
Recent data have suggested that the elastic properties of chest wall (CW) may be compromised in patients with ARDS because abdominal distension (4). We partitioned CW and lung (L) mechanics, assessed role distension, verified whether underlying disease responsible for affects impairment respiratory mechanics. Volume-pressure (V-P) curves (interrupter technique) were nine surgical medical ARDS. Relative to undergoing heart surgery, V-P system (rs) L or showed a rightward displacement. an...
To understand the role of patient-ventilator asynchrony in etiology sleep disruption and determine whether optimizing interactions by using proportional assist ventilation improves sleep.Randomized crossover clinical trial.A tertiary university medical-surgical intensive care unit.Thirteen patients during weaning from mechanical ventilation.Patients were randomized to receive pressure support or on first night then crossed over alternative mode for second night. Polysomnography measurement...
Objective To evaluate whether the shape of airway pressure-time (Paw-t) curve during constant flow inflation corresponds to radiologic evidence tidal recruitment or hyperinflation in an experimental model acute lung injury. Design Prospective randomized laboratory animal investigation. Setting Department Clinical Physiology, University Uppsala, Sweden. Subjects Anesthetized, paralyzed, and mechanically ventilated pigs. Interventions Acute injury was induced by lavage. During inspiratory...
Although a significant number of patients with severe brain injury develop acute lung injury, only intracranial risk factors have previously been studied. We investigated the role extracranial predisposing factors, including hemodynamic and ventilatory management, as independent predictors in brain-injured patients.Prospective multicenter observational study.Four European intensive care units university-affiliated hospitals.Eighty-six severely enrolled 13 months.None.All (Glasgow Coma Scale...
Background We tested the hypothesis that pressure-time (P-t) curve during constant flow ventilation can be used to set a noninjurious ventilatory strategy. Methods In an isolated, nonperfused, lavaged model of acute lung injury, tidal volume and positive end-expiratory pressure were obtain: (1) straight P-t (constant compliance, minimal stress); (2) downward concavity in (increasing low (3) upward (decreasing high stress). The was fitted to: P = a. tb +c, where b describes shape curve, 1...
Abstract Introduction The impact of gender on outcome in critically ill patients is unclear. Weinvestigated the influence epidemiology severe sepsis andassociated morbidity and mortality a large cohort ICU regionof Piedmont Italy. Methods This was post-hoc analysis data from prospective, multicenter,observational study which all admitted to one 24 participatingmedical and/or surgical ICUs between 3 April 2006 29 September wereincluded. Results Of 3,902 included study, 63.5% were male. Female...
To assess efficacy and safety of noninvasive ventilation-plus-extracorporeal Co2 removal in comparison to ventilation-only prevent endotracheal intubation patients with acute hypercapnic respiratory failure at risk failing ventilation.Matched cohort study historical control.Two academic Italian ICUs.Patients treated ventilation for due exacerbation chronic obstructive pulmonary disease (May 2011 November 2013).Extracorporeal CO2 was added when (arterial pH ≤ 7.30 arterial PCO2 > 20%...
The objective of this study was to compare patient-ventilator interaction during pressure-support ventilation (PSV) and proportional-assist (PAV) in the course increased ventilatory requirement obtained by adding a dead space 12 patients on weaning from mechanical ventilation. With PSV, level unloading provided setting inspiratory pressure at 20 10 cmH2O, whereas with PAV 80 40% elastic resistive load. Hypercapnia (P < 0.001) tidal swing esophageal pressure-time product per breath both...
In patients with acute respiratory distress syndrome (ARDS), the ventilatory approach is based on tidal volume (VT) of 10-15 ml/kg and positive end-expiratory pressure (PEEP). To avoid further pulmonary injury, decreasing VT allowing PaCO2 to increase (permissive hypercapnia) has been suggested. Effects 10 cmH2O PEEP mechanics, hemodynamics, gas exchange were compared during mechanical ventilation conventional (10-15 ml/kg) low (5-8 VT.Nine sedated paralyzed studied. was decreased gradually...