A5102812458- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury Research
- Spinal Hematomas and Complications
- Cardiac Arrest and Resuscitation
- S100 Proteins and Annexins
- Child Abuse and Related Trauma
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Blood donation and transfusion practices
- Radiation Dose and Imaging
- Trauma Management and Diagnosis
- Tryptophan and brain disorders
- Cardiovascular Syncope and Autonomic Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Electrolyte and hormonal disorders
- Autopsy Techniques and Outcomes
- Head and Neck Surgical Oncology
- Hallucinations in medical conditions
- Psychosomatic Disorders and Their Treatments
- Hepatitis B Virus Studies
- Heart Rate Variability and Autonomic Control
- Folate and B Vitamins Research
- Blood disorders and treatments
University of Groningen
2020-2024
University Medical Center Groningen
2012-2024
Erasmus MC
2023
Radboud University Nijmegen
2009
Radboud University Medical Center
2009
The role of glucocorticoids without surgical evacuation in the treatment chronic subdural hematoma is unclear.In this multicenter, open-label, controlled, noninferiority trial, we randomly assigned symptomatic patients with a 1:1 ratio to 19-day tapering course dexamethasone or burr-hole drainage. primary end point was functional outcome at 3 months after randomization, as assessed by score on modified Rankin scale (range, 0 [no symptoms] 6 [death]). Noninferiority defined lower limit 95%...
Surgery and specifically burr hole craniostomy is the most common first choice treatment of patients with Chronic Subdural Hematoma (CSDH). However, several aspects neurosurgical peri-operative management are still a subject research, such as how to treat bilateral CSDH anesthetic approach. We aim investigate effect surgical approach anesthesia modality on outcome patients.
Abstract Purpose Chronic subdural hematoma (CSDH) is a common neurological disease often affecting the elderly. Long-term excess mortality for patients after CSDH has been suggested but causes of death are unknown. We hypothesize that related to frailty. In this article, we describe rates and compared with general population assess association frailty mortality. Methods A cohort study in which consecutive were regarding rates. Furthermore, six indicators (cognitive problems, frequent...
Patients with chronic subdural hematoma (CSDH) can present a variety of signs and symptoms. The relationship these symptoms functional outcome is unknown. Knowledge associations might aid clinicians in the choice to initiate treatment may allow them better inform patients on expected outcomes.To investigate if presenting influence CSDH.We conducted retrospective analysis consecutive CSDH three hospitals. Glasgow Outcome Scale Extended (GOS-E) scores were obtained from first follow-up visit...
Chronic subdural hematoma (CSDH) is a frequent pathological entity in daily clinical practice. However, evidence-based CSDH-guidelines are lacking and level I evidence from randomized trials (RCTs) limited. In order to establish subsequently implement guideline, insight into current practice attitudes toward CSDH-treatment required. The aim explore CSDH-management the Netherlands.A national online survey was distributed among Dutch neurologists neurosurgeons, examining variation through...
Abstract Serum concentrations of free thiols (key components the extracellular antioxidant machinery) reflect overall redox status human body. The objective this exploratory study was to determine serum in acute phase after traumatic brain injury (TBI) and their association with long-term outcome. In observational cohort study, patients TBI various severity were included from a biobank prospectively enrolled patients. Further eligibility criteria an available blood sample head computed...
A potential source of novel biomarkers for mTBI is the kynurenine pathway (KP), a metabolic tryptophan (Trp), that up-regulated by neuroinflammation and stress. Considering metabolites KP (kynurenines) are implicated in various neuropsychiatric diseases, exploration this could potentially bridge gap between physiological psychological factors recovery process after mTBI. This study, therefore, set out to characterize examine associations with long-term outcome. Patients were prospectively...
Few studies on traumatic brain injury (TBI) have investigated the stability of blood serum biomarkers after long-term storage at low temperatures. In current feasibility study we analyzed acute phase samples from patients with mild TBI as well moderate and severe that were collected more than 10 years ago ( old ). We particularly interested in TBI, because effects are subtle this category compared to moderate-severe TBI. Therefore, primary objective was find out whether several still...
Abstract Objective Chronic subdural hematoma (CSDH) is a common neurological condition, often affecting the elderly. Cognitive impairment frequently observed at presentation. However, course and longer term aspects of cognitive status CSDH patients are unknown. In this study, we aim to explore after treatment. Methods An exploratory study in which were assessed 3 months treatment compared healthy controls. A total 56 (age 72.1 SD ± 10.8 years with 43 [77%] males) 60 controls included 67.5...
Computed tomography (CT) brain imaging is routinely used to support clinical decision-making in patients with traumatic injury (TBI). Only 7% of scans, however, demonstrate evidence TBI. The other 93% scans contribute a significant cost the healthcare system and radiation risk patients. There may be better strategies identify which patients, particularly those mild TBI, are at deterioration require hospital admission. We introduce blood serum liquid biopsy that utilizes attenuated total...
Abstract Background Several prognostic models for outcomes after chronic subdural hematoma (CSDH) treatment have been published in recent years. However, these are not sufficiently validated use daily clinical practice. We aimed to assess the performance of existing prediction patients diagnosed with CSDH. Methods systematically searched relevant literature databases up February 2021 identify outcome For external validation models, we used a retrospective database, containing data 2384 from...
Abstract The erythropoietic porphyrias are primarily manifested by skin sensitivity. They are, unlike many other forms of porphyria, usually not associated with neurologic manifestations. Only a few cases have been reported neuropathy in patients porphyrias, all characterized an acute motor and proximally accentuated occurring the setting hepatic failure. In this report, we present patient without failure who presented sensorimotor axonal polyneuropathy before being diagnosed porphyrias....
Purpose Mild traumatic brain injury (TBI) is one of the most common causes morbidity worldwide. Patients at risk unfavourable outcome may benefit from additional attention and help but identification these patients necessitates development diagnostic methods to assess indices an early stage. The aim this overview highlight studies that reflect growing scientific diagnosis prognostication mild TBI. Recent findings value serum biomarkers for TBI severity has been acknowledged in recent...