A5067100846- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Dermatological and COVID-19 studies
- Organ and Tissue Transplantation Research
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune and Inflammatory Disorders Research
- Peripheral Neuropathies and Disorders
- Colorectal Cancer Treatments and Studies
- Genetic Associations and Epidemiology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Colorectal and Anal Carcinomas
- Organ Donation and Transplantation
- Dermatologic Treatments and Research
Tufts University
2022-2025
Innsbruck Medical University
2024
Universität Innsbruck
2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Brigham and Women's Hospital
2018-2022
Harvard University
2018-2022
Ibero American University
2019
To evaluate rheumatoid arthritis (RA) disease activity and risk of RA-associated interstitial lung (RA-ILD).We investigated RA-ILD using the Brigham RA Sequential Study (BRASS, 2003-2016). All patients were diagnosed as having according to accepted criteria. Disease Activity Scores in 28 joints (DAS28) covariate data measured prospectively at annual study visits. Diagnosis was determined by review images from clinically indicated chest computed tomography scans. We analyzed without baseline....
Objective To evaluate the effects of long‐term physical activity on subsequent risk rheumatoid arthritis ( RA ) in a prospective cohort study. Methods This study investigated and among women from Nurses' Health Study II (1989–2015). Physical exposures covariates were prospectively obtained using biennial questionnaires. Two rheumatologists independently reviewed medical records who self‐reported new diagnosis questionnaires screened positive for based supplemental survey. All incident cases...
Patients with immune-mediated diseases treated anti-CD20 monoclonal antibodies may have worse coronavirus disease 2019 (COVID-19) outcomes due to impaired humoral immunity, but differences compared the general population are unknown.We identified patients who received within 1 year prior index date of polymerase chain reaction-confirmed COVID-19 between January 31, 2020, and 2021. General comparators were matched up 5:1 by age, sex, reaction date. Unadjusted multivariable adjusted (for race,...
To investigate the associations of common MUC5B promoter variant with timing RA-associated interstitial lung disease (RA-ILD) and RA onset.We identified patients meeting 2010 ACR/EULAR criteria available genotype information in Mass General Brigham Biobank, a multihospital biospecimen clinical data collection research study. We determined RA-ILD presence by reviewing all who had CT imaging, biopsy or autopsy results. dates diagnoses manual records review. examined (G>T at rs35705950) RA-ILD,...
To identify predictors of rheumatic immune-related adverse events (irAEs) following immune checkpoint inhibitor (ICI) treatment for cancer.
Background: Robin sequence is an anomaly of micrognathia, glossoptosis, and airway obstruction. Mandibular distraction osteogenesis (MDO) performed in early infancy relieves obstruction improves feeding difficulties. Though clinical outcomes data for MDO are strong, studies examining the cost drivers procedure scarce. Methods: A retrospective 10-year single-institution chart review examined medical billing records infants undergoing at urban tertiary care center. Data included hospital...
Anti-citrullinated protein antibodies (ACPA) are central to rheumatoid arthritis (RA) pathogenesis and may develop at inflamed mucosa. We investigated whether asthma, a disease of airway mucosal inflammation, was associated with elevated ACPA before RA diagnosis.We performed nested case-control study among women in two prospective cohorts, the Nurses' Health Study (NHS; 1976-2014) NHSII (1989-2015). Blood obtained on subset (NHS: 1989-1990; NHSII: 1996-1999). Cases met 1987 ACR or 2010...
To investigate elevation of anti-citrullinated protein antibodies (ACPAs) before diagnosis rheumatoid arthritis (RA) and risks for chronic obstructive pulmonary disease (COPD) or asthma.
We aimed to determine whether specific respiratory tract diseases are associated with increased rheumatoid arthritis (RA) risk.This case-control study within the Mass General Brigham Biobank matched newly diagnosed RA cases 3 controls on age, sex, and electronic health record history. identified using a validated algorithm confirmed by medical review. Respiratory disease exposure required 1 inpatient or 2 outpatient codes at least years before index date of clinical diagnosis date. Logistic...
Objective To investigate the risk of progression to rheumatoid arthritis (RA) in patients who were cyclic citrullinated peptide (CCP) antibody positive without RA at initial presentation. Methods We performed a retrospective cohort study CCP+ individuals seen US tertiary care system between 2009 and 2018 or other systemic rheumatic disease by medical record review time CCP positivity. Progression classifiable was determined through review. investigated overall stratified level (low: >1 2×...
Abstract Objectives Pulmonary disease is a common extraarticular manifestation of RA associated with increased morbidity and mortality. No current strategies exist for screening this at-risk population parenchymal lung disease, including emphysema interstitial (ILD). Methods patients without diagnosis ILD or chronic obstructive pulmonary underwent prospective comprehensive clinical, laboratory, functional radiological evaluations. High resolution CT (HRCT) scans were scored preclinical...
To investigate the effect of providing comprehensive personalized risk information on concern for chronic disease development.Unaffected first-degree relatives (FDRs) rheumatoid arthritis (RA) patients (n = 238) were randomly allocated to: 1) disclosure RA to demographics, genetics, biomarkers, and behaviors using a web-based tool (PRE-RA arm, n 78); 2) PRE-RA with interpretation by health educator Plus 80); 3) standard education (Comparison 80). Concern developing was assessed at baseline...
COVID-19 patients with rheumatic disease have a higher risk of mechanical ventilation than the general population. The present study was undertaken to assess lung involvement using validated deep learning algorithm that extracts quantitative measure radiographic severity.We performed comparative cohort and ≥1 chest radiograph within ±2 weeks diagnosis matched comparators. We used unadjusted adjusted (for age, Charlson comorbidity index, interstitial disease) quantile regression compare...
Oncoplastic breast reduction mammoplasty (ORM) is an excellent treatment option for women with cancer and macromastia undergoing conservation therapy. Here, we aim to better understand the risks associated ORM compared standard (SRM).A retrospective chart review was performed of patients or SRM from 2015 2021. Primary outcomes included occurrence major minor postoperative complications in two groups delays adjuvant therapy (>90 days) among ORM.Women group (n = 198) were significantly older...
Vascularized Composite Allotransplantation (VCA) offers a unique option to restore form and function after limb loss or facial trauma that cannot be satisfactorily accomplished through traditional prosthetics reconstructions. Establishing successful Upper Extremity Transplantation (UET) program requires strong leadership structured surgical team, extensive interdisciplinary collaboration. We conducted qualitative study among 12 health care professionals patients. Informed consent was...
Abstract Objective Patients with immune-mediated diseases treated CD20 inhibitors may have worse COVID-19 outcomes due to impaired humoral immunity, but differences versus the general population are unknown. Methods We identified patients who received within one year prior index date of PCR-confirmed between January 31, 2020, and 2021. Comparators were matched up 5:1 by age, sex, PCR date. Hazard ratios (HRs) 95% confidence intervals (CIs) for hospitalization, mechanical ventilation, death...
To describe disease-modifying antirheumatic drug (DMARD) disruption, rheumatic disease flare/activity, and prolonged COVID-19 symptom duration among survivors with systemic autoimmune diseases (SARDs).