A5021023870- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Hepatitis C virus research
- Renal Diseases and Glomerulopathies
- Inflammatory Bowel Disease
- Multiple Sclerosis Research Studies
- Toxin Mechanisms and Immunotoxins
- Orthopedic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Peripheral Neuropathies and Disorders
- Cytokine Signaling Pathways and Interactions
- Biochemical and Molecular Research
- Ocular Diseases and Behçet’s Syndrome
- Colorectal and Anal Carcinomas
- Chronic Lymphocytic Leukemia Research
- Delphi Technique in Research
- Autoimmune and Inflammatory Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Lymphoma Diagnosis and Treatment
- Complement system in diseases
- Mitochondrial Function and Pathology
University of Michigan
2023
Tufts University
2021
Brigham and Women's Hospital
2018-2020
Harvard University
2019-2020
Objective To investigate the impact and timing of smoking cessation on developing rheumatoid arthritis (RA) serologic phenotypes. Methods We investigated RA risk in Nurses’ Health Study (NHS) (1976–2014) NHS II (1989–2015). Smoking exposures covariates were obtained by biennial questionnaires. Self‐reported was confirmed medical record review for American College Rheumatology/European League Against Rheumatism criteria. Cox regression used to estimate hazard ratios (HRs) 95% confidence...
Objective To evaluate the effects of long‐term physical activity on subsequent risk rheumatoid arthritis ( RA ) in a prospective cohort study. Methods This study investigated and among women from Nurses' Health Study II (1989–2015). Physical exposures covariates were prospectively obtained using biennial questionnaires. Two rheumatologists independently reviewed medical records who self‐reported new diagnosis questionnaires screened positive for based supplemental survey. All incident cases...
Anti-citrullinated protein antibodies (ACPA) are central to rheumatoid arthritis (RA) pathogenesis and may develop at inflamed mucosa. We investigated whether asthma, a disease of airway mucosal inflammation, was associated with elevated ACPA before RA diagnosis.We performed nested case-control study among women in two prospective cohorts, the Nurses' Health Study (NHS; 1976-2014) NHSII (1989-2015). Blood obtained on subset (NHS: 1989-1990; NHSII: 1996-1999). Cases met 1987 ACR or 2010...
To investigate elevation of anti-citrullinated protein antibodies (ACPAs) before diagnosis rheumatoid arthritis (RA) and risks for chronic obstructive pulmonary disease (COPD) or asthma.
Abstract Objectives RA develops slowly over years. We tested for metabolic changes prior to onset using a large non-targeted metabolomics platform identify novel pathways and advance understanding of development. Methods Two hundred fifty-four incident cases with plasma samples drawn pre-RA in the Nurses’ Health Study (NHS) cohorts were matched 1:2 501 controls on age, race, menopause/post-menopausal hormone use blood collection features. Relative abundances 360 unique, known metabolites...
Objective Non-infectious myelitis in systemic lupus erythematosus (SLE) may be due to SLE myelitis, comorbid multiple sclerosis (MS), or neuromyelitis optica (NMO). We compared characteristics of these three conditions patients at a large academic institution. Methods searched for neurologic diagnoses NMO and MS among 2297 with least four 1997 American College Rheumatology revised criteria between 2000 2015. Each subject was reviewed by neurologist confirm the underlying diagnosis....
SLE is associated with high risks of cardiovascular disease (CVD) and mortality, has a wide spectrum presentations. We investigated whether severity at diagnosis was CVD or mortality risk.Within Medicaid (2000-10), we identified patients 18-65 years age incident SLE. Initial classified-mild, moderate, severe-during the baseline year prior to start follow-up (incident index date) using published algorithm based on SLE-related medications diagnoses. Patients were followed from date first event...
To identify interactions between genetic factors and current or recent smoking in relation to risk of developing systemic lupus erythematosus (SLE).For the study, 673 patients with SLE (diagnosed according American College Rheumatology 1997 updated classification criteria) were matched by age, sex, race (first 3 principal components) 3,272 control subjects without a history connective tissue disease. Smoking status was classified as smoking/having recently quit within 4 years before...
Abstract Objective Lupus nephritis (LN) increases the risks of end-stage renal disease (ESRD) and death, but these are difficult to estimate. Since complement factors play an essential role in pathogenesis deposited kidneys as C1q C3, we studied whether deposits predict ESRD death patients with LN. Methods We collected demographic, clinical pathological data from 183 adult LN classes II–V diagnosed a first native kidney biopsy. Pathological included localization intensity immunofluorescence...
<h3>Background</h3> Anti-citrullinated protein antibodies (ACPA) are central to RA pathogenesis, with serum ACPA titers elevated years prior clinical onset. Aberrant citrullination may occur in inflamed airway mucosa, forming neoantigens producing before articular involvement. Thus, individuals inflammatory diseases, such as asthma, be susceptible RA-related autoimmunity. <h3>Objectives</h3> To investigate asthma a risk factor for ACPA+ <h3>Methods</h3> We performed cross-sectional analysis...
<h3>Background</h3> SLE severity is heterogeneous: some patients have mild disease with rashes and arthritis, while others severe multi-organ system involvement. It challenging to study in administrative databases given this heterogeneity. Garris et al developed an claims-based algorithm derived from elements of the SLEDAI, SLAM BILAG instruments (Garris, J Med Econ 2013). employs ICD-9, CPT NDC claims over a 1 year period classifies as having mild, moderate or disease. We sought validate...
May 5, 2019April 9, 2019Free AccessMyelitis Associated with Systemic Lupus Erythematous: Is it Myelitis, Neuromyelitis Optica, or Multiple Sclerosis? (P1.2-079)Anne-Katrin Pröbstel, Jessica N. Williams, Cameron B. Speyer, Dorlan Kimbrough, Christoph Schankin, Carlo Chizzolini, Marten Trendelenburg, Tobias Derfuss, Karen Costenbader, and Shamik BhattacharyyaAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P1.2-079 Letters to the Editor