A5090400633- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- Salivary Gland Disorders and Functions
- Spondyloarthritis Studies and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ocular Diseases and Behçet’s Syndrome
- Otitis Media and Relapsing Polychondritis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Salivary Gland Tumors Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Peripheral Neuropathies and Disorders
- Advancements in Semiconductor Devices and Circuit Design
- Psoriasis: Treatment and Pathogenesis
- Renal Diseases and Glomerulopathies
- Semiconductor materials and devices
- Growth Hormone and Insulin-like Growth Factors
- Dialysis and Renal Disease Management
- Advancements in Photolithography Techniques
- Family and Disability Support Research
- Dermatology and Skin Diseases
- Systemic Sclerosis and Related Diseases
- Insect and Pesticide Research
- Inflammatory Myopathies and Dermatomyositis
Seoul Medical Center
2014-2023
Seoul Metropolitan Government
2009-2021
Seoul National University
2002-2014
Seoul National University Bundang Hospital
2013
Objective To quantify autonomic dysfunction in fibromyalgia patients compared to healthy controls using heart rate variability (HRV). Methods Sixteen with and 16 were recruited this case control study. HRV was measured the time-domain method incorporating following parameters: total heartbeats, mean of intervals between consecutive heartbeats (R-R intervals), standard deviation normal R-R (SDNN), square root squared differences successive (RMSSD), ratio SDNN RMSSD (SDNN/RMSSD), difference...
Between 2003 and 2005, a total of 11,716 samples were collected analysed to determine the level pesticides residues. Multi-residue methods (MRMs) capable simultaneously determining 250 used. Of samples, 89.1% had no detectable residues 1.7% violative The detection rates by commodity group 11.4, 8.6, 0.3, 0.02% for vegetables, fruit, grain, mushrooms, others, respectively. Agricultural products with pesticide pepper, Perilla frutescens, leafy lettuce spinach in decreasing order. that...
Abstract To evaluate the efficacy and safety of infliximab biosimilar CT-P13 in patients with active Takayasu arteritis (TAK). In this single-center open-label trial, TAK received at a starting dose 5 mg/kg weeks 0, 2, 6, then every 8 up to week 46. They were followed until 54. From 14 46, inadequate response increased by 1.5 mg/kg. Concomitant prednisolone was allowed ≤ 10 mg/day. The primary end point achievement partial or complete remission 30. All underwent positron emission...
Background: Although microbes have been suggested to play a role in the pathogenesis of ankylosing spondylitis (AS), several studies present contradictory results regarding association between AS and chronic periodontitis (CP). Methods: Clinical, laboratory, medication data were collected from 84 patients with age‐ sex‐matched controls. Periodontal measurements, including probing depths (PDs), clinical attachment loss (AL), serum anti‐ Porphyromonas gingivalis titers, detection P. DNA...
The study investigated the association between disease activity and serum 25-hydroxyvitamin D3 (25(OH)-D3), B cell activation of tumor necrosis factor family (BAFF), or β 2 microglobulin in patients with primary Sjogren’s syndrome (SS). Sixty-nine SS 22 sicca control were included study. Disease was measured EULAR index (ESSDAI). Serum levels 25(OH)-D3 by radioimmunoassay BAFF an enzyme-linked immunosorbent assay. significantly lower compared to controls (<mml:math...
The objective of this study was to investigate CXC chemokines and its receptor in patients with Behcet's disease (BD) their associations activity. Blood samples were collected from 109 BD 36 age- sex-matched healthy controls (HCs). Twenty-two follow-up blood patients. Serum (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13 CXCL16) cell surface marker expression (CD3, CD4 CXCR3) peripheral mononuclear cells (PBMCs) assayed. Clinical features including activity evaluated at the time collection....
Objective The objective of this study is to examine the prevalence depression and its related factors including quality life, brain-derived neurotrophic factor (BDNF), vitamin D in patients with systemic lupus erythematosus (SLE). Methods Depression was assessed using center for epidemiologic studies (CES-D) scale. Disease activity, disease-related organ damage, EuroQol-5 dimensions (EQ-5D), sociodemographic features, laboratory tests serum level were surveyed. Serum BDNF measured an...
Background There is increasing interest in the quality of health care and considerable efforts are being made to improve it. Rheumatoid arthritis (RA) a disease that can result favorable outcomes when appropriate diagnosis treatment provided. However, several studies have shown RA often managed inappropriately. Therefore, Korean College Rheumatology aimed develop indicators (QIs) evaluate patients with RA. Methods Preliminary QIs were derived based on existing guidelines for The final...
Byoong Yong Choi, M.D., Myeung-Su Lee, Ph.D., Geun Tae Kim, Seung-Jae Hong, Eun Bong Han Joo Baek, Ph.D. J Rheum Dis -0001;0:. https://doi.org/10.4078/jrd.2023.0068
50 nm long MOSFETs with side-gates were optimised in terms of the side-gate length and successfully fabricated conventional MOS technology. The simulated MOSFET shows a reasonable subthreshold swing 81 mV/dec low drain induced barrier lowering 77 mV.
Background/Aims: It is unknown whether pulmonary rehabilitation (PR) an effective intervention to manage coal-worker pneumoconiosis (CWP).We evaluated the efficacy and safety of individualized PR program in 53 patients with CWP hospitalized two medical institutions.Methods: The consisted upper lower extremity exercises improve exercise endurance skeletal musculoskeletal strength.All subjects performed treadmill ergometer steady loading weights three times/week for 12 weeks.The following...
Objectives To investigate the clinical findings upon initial diagnosis and extraglandular manifestations in Korean patients with primary Sjögren's syndrome (pSS). Methods We collected laboratory data from 238 pSS enrolled at Seoul National University Hospital, Bundang Hospital Medical Center March 2011 to December 2014. All met American-European Consensus Group criteria for pSS. Results Upon diagnosis, sicca symptoms (xerophthalmia or xerostomia) as chief complaint were only observed 129...
Primary Sjögren's syndrome (pSS) is characterized by chronic inflammation and dysfunction in exocrine organs; however, it also has protean clinical features, including neuropsychiatric symptoms. A major neurological manifestation peripheral neuropathy involvement of the central nervous system uncommonly described pSS. 52-year-old female was admitted because depression, dysarthria, gait abnormality, memory disturbance, which had developed over two months, diagnosed as She treated successfully...
The twin SONOS memory (TSM) transistors for 2-bit/cell non-volatile-memory (NVM) application are presented and their reliability is evaluated so that they can be applied to next generation NVM technology. This new memory, which implemented by the damascene gate outer sidewall spacer processes, shows a high down 80 nm length.
Polyarteritis nodosa (PAN) has a broad spectrum of clinical presentation, since it affects small and medium-sized muscular arteries with microaneurysm formation, aneurysmal rupture hemorrhage, thrombosis, and, consequently, organ ischemia or infarction. Although skeletal muscle involvement is well documented in patients PAN, can mimic more common diseases, cause confusion delays diagnosis. PAN may have limited early systemic forms benign course excellent response to corticosteroid therapy....
The study aimed to ascertain the clinical manifestations of inflammatory arthritis accompanying tuberculosis (TB) for differential diagnosis.We retrospectively reviewed patients with active TB who presented arthropathy at Seoul Medical Center. Among 2,872 infection, 47 had 14 crystal-induced arthropathy; 12, arthritis; Poncet's disease (PD); 8, Rheumatoid (RA); and 1, septic arthritis. characteristics laboratory radiographic findings each group were analyzed.In arthritis, weight-bearing...
Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disorder that impairs patients' overall health-related quality of life (HRQOL) In this study, we evaluated the effect adalimumab in Korean patients with active RA on HRQOL.Patients included study had moderate to severe did not respond conventional drugs Disease Activity Score 28 joints >32 and were biologics-naïve All received 40 mg subcutaneously every other week followed for 24 weeks The primary endpoint was change baseline...
A 46-year-old man was admitted to our hospital because of a fever unknown origin.The patient had skin rash, arthralgia, and hepatosplenomegaly.Laboratory tests showed leukemoid leukocytosis, high serum ferritin level (31,200 ng/mL), abnormal liver function tests.He initially diagnosed with adult-onset Still's disease (AOSD).However, imaging studies incidentally detected cold abscess involving the 11th thoracic vertebra.A biopsy revealed histologically granulomatous caseous necrosis, positive...
Takayasu's arteritis (TA), a granulomatous vasculitis, affects the aorta and its major branches. Glucocorticoids are an effective treatment for patients with active TA, but some fail to achieve or maintain remission conventional therapy, side effects resulting from long-term glucocorticoid therapy potentially serious. Anti-tumor necrosis factor-α agents, such as infliximab, may be efficient in refractory TA. We report on 24-year-old female patient TA who 18 F-fluoro-2-de-was treated...
<h3>Background</h3> Chemokines are multifunctional mediators that control leukocyte recruitment into the inflammatory sites and enhance immune responses. It remains to be investigated which chemokines important in Behcet9s disease (BD). <h3>Objectives</h3> The objective of this study was investigate serum levels neutrophil lymphocyte chemoattractants BD patients its association with activity symptoms. <h3>Methods</h3> We collected sera from (n=64) age-, sex matched healthy controls (n=21)....