A5058620289- Vasculitis and related conditions
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Otitis Media and Relapsing Polychondritis
- Vaccine Coverage and Hesitancy
- Pneumocystis jirovecii pneumonia detection and treatment
- Spondyloarthritis Studies and Treatments
- Neurogenetic and Muscular Disorders Research
- Biochemical and Molecular Research
- Systemic Sclerosis and Related Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Case Reports on Hematomas
- interferon and immune responses
- Gout, Hyperuricemia, Uric Acid
- Disaster Response and Management
- Patient-Provider Communication in Healthcare
- Ultrasound in Clinical Applications
Fred Hutch Cancer Center
2025
University of Washington
2013-2025
Seattle University
2021-2025
Virginia Mason Medical Center
2024
Boston University
2022
Tufts University
2022
St. Elizabeth's Medical Center
2022
Digital Research Alliance of Canada
2021
Psoriasis Association
2021
Center for Rheumatology
2018
Background: Communication with patients and families is an essential component of high-quality care in serious illness. Small-group skills training can result new communication behaviors, but past studies have used facilitators extensive experience, raising concerns this not scalable. Objective: The objective was to investigate the effect experiential building workshop (Codetalk), led by newly trained facilitators, on internal medicine trainees' nurse practitioner students' ability...
Objective To test whether messenger RNA (mRNA) splicing is altered in neutrophils from patients with systemic lupus erythematosus (SLE) and can produce neoantigens. Methods sequencing of SLE (n = 15) healthy donors 12) were analyzed for mRNA using the RiboSplitter pipeline, an event‐focused tool based on SplAdder subsequent translation protein domain annotation. SARS‐CoV2–infected individuals was used as additional comparator. Results Neutrophils contained 521 statistically significant...
ABSTRACT Approximately 17% of our genome consists copies the retrotransposon “ l ong in terspersed e lement‐1” (LINE‐1 or L1). Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against L1‐encoded ORF1 protein (ORF1p), which correlate disease activity and interferon gene signature. ORF1p is present neutrophils from patients active perinuclear ribonucleoprotein particles that also contain Ro60 nucleic acid sensors. Here, we report treatment monocytes demethylating...
Objective Despite the high risk for permanent vision loss in elderly individuals with giant cell arteritis (GCA), initiation of subcutaneous tocilizumab (TCZ) is often delayed. We used chart review GCA patients prescribed TCZ to investigate delays drug initiation. Methods included 82 at University Washington between 2017 and 2024. Time from medication request approval/start cost were compared by insurance payor using 1-way ANOVA. Use copay assistance, prior authorization requirement,...
To illuminate the poorly understood aetiology of SLE by comparing gene expression profile neutrophils with that from patients infected SARS-CoV-2, a disease (COVID-19) well-defined antigens and similar type I interferon response. RNA sequencing (n=15) healthy controls (n=12) was analysed for differential modulated pathways. The same analyses were performed on neutrophil dataset SARS-CoV-2 infection (n=30) (n=8). Next, we carried out comparative to identify common unique transcriptional...
Abstract Background Patients with systemic lupus erythematosus (SLE) have autoantibodies against the L1-encoded open-reading frame 1 protein (ORF1p). Here, we report (i) which immune cells ORF1p emanates from, (ii) L1 loci are transcriptionally active, (iii) whether express L1-dependent interferon and interferon-stimulated genes, (iv) effect of inhibition ORF2p by reverse transcriptase inhibitors. Results was detected flow cytometry primarily in SLE CD66b + CD15 regular low-density...
Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an unpredictable course of recurrent exacerbations alternating more stable disease. SLE characterized by broad immune activation and autoantibodies against double-stranded DNA numerous proteins that exist in cells as aggregates nucleic acids, such Ro60, MOV10, the L1 retrotransposon-encoded ORF1p. Results Here we report these 3 are co-expressed co-localized subset granulocytes concentrated cytosolic...
ObjectiveLassa fever (LF) a hemorrhagic endemic to Western has an incidence of approximately 500,000 cases per year. Here, we evaluate hearing loss and other sequelae following LF.MethodsThis case-control study enrolled laboratory confirmed LF survivors, non-LF Febrile controls Matched Community with no history or recent hospitalization for febrile illness.Study participants completed symptom questionnaire. Pure-tone audiometry was by subset participants.ResultsOne hundred forty-seven...
The study objective was to assess sociodemographic disparities in telehealth use among patients an urban adult rheumatology clinic during the coronavirus disease 2019 (COVID-19) pandemic.In this retrospective cohort study, patient-level data associated with all visits following two periods were reviewed: pre-COVID-19 (March 1, February 28, 2020) and COVID-19 (April 2020 March 31, 2021). Data extracted from electronic health record. Multivariable logistic regression analyses performed...
We developed a fast-track clinic (FTC) to expedite the evaluation of patients suspected having giant cell arteritis (GCA) using vascular ultrasound. Though FTCs have demonstrated efficacy in Europe, no protocolized United States has been developed. This study introduces new FTC model unique States, sonographers, and describes protocols used develop reliable findings. evaluate clinical outcomes ultrasound temporal artery biopsy (TAB).
Many patients suffering from autoimmune diseases have autoantibodies against proteins encoded by genomic retroelements, suggesting that normal epigenetic silencing is insufficient to prevent the production of for which immune tolerance appears be limited. One such protein transmembrane envelope (Env) human endogenous retrovirus K (HERV-K). We reported recently with rheumatoid arthritis (RA) IgG recognize Env. Here, we use RNA sequencing RA neutrophils analyze HERV-K expression and find only...
Vascular ultrasound has been increasingly used to diagnose giant cell arteritis (GCA). The temporal and axillary arteries are commonly evaluated. However, the usefulness of including subclavian artery remains unclear. This study investigated whether inclusion in addition evaluation GCA improves accuracy examination beyond ultrasonography alone.We formed a fast-track clinic use rapidly evaluate patients with suspected GCA. In this cohort study, referred for new concern received vascular...
Tuberculous pleural effusion occurs in approximately 5% of patients with Mycobacterium tuberculosis (TB) infection[1][1] and accounts for 4% all TB cases the United States.[2][2] Diagnosis is challenging, 48–96% tuberculous effusions negative by sputum acid-fast bacilli (AFB
Treat-to-target is the recommended strategy for management of rheumatoid arthritis (RA) and involves regular assessment disease activity using validated measures subsequent adjustment medical therapy if patients are not in remission or low activity. Recommendations published 2012 detailed preferred but there have been few publications on implementation a real-world clinic setting. Plan-Do-Study-Act (PDSA) methodology was used over two cycles with goal increasing provider measurement during...
Therapies for COVID-19 prevention or treatment continue to play a significant role individuals who are not able mount an adequate immune response after vaccination and/or in patients at high-risk severe outcomes of infection. As these modalities have become more available, it is important assess the public's interest agents ensure both and physicians aware therapeutics available them. Google Trends freely tool that researchers can use monitoring public by analyzing trends search queries...
Vascular ultrasound is commonly used to diagnose giant cell arteritis (GCA). Most protocols include the temporal arteries and axillary arteries, but it unclear which other should be included. This study investigated whether inclusion of intima media thickness (IMT) common carotid artery (CCA) in evaluation GCA improves accuracy examination.