A5095764906- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
Medical University Plovdiv
2024
The endometrium, the inner mucosal lining of uterus, undergoes complex molecular and cellular changes across menstrual cycle in preparation for embryo implantation. Transcriptome-wide analyses have mainly been utilized to study endometrial receptivity, prerequisite successful implantation, with most studies, so far, comparing transcriptomes between (i) secretory proliferative endometrium or (ii) mid-secretory early endometrium. In current study, we provide a complete transcriptome...
The endometrium, the inner mucosal lining of uterus, undergoes complex molecular and cellular changes across menstrual cycle in preparation for embryo implantation. Transcrip-tome-wide analyses have mainly been utilized to study endometrial receptivity, prerequisite successful implantation, with most studies, so far, comparing transcriptomes between (i) secretory versus proliferative endometrium or (ii) mid-secretory early-secretory endometrium. In current study, we provide complete...
The connection between the mother and child has been considered one of strongest bonds in nature. Though there are numerous factors that can influence establishment pregnancy, its essence three major: a good quality embryo, receptive endometrium successful cross-talk them. placenta, derives from trophoblast develops when implantation occurs. It is an ephemeral organ through which turnover nutrient, gas waste molecules realized. serves as barrier provide embryo with immune factors. Placental...
Abstract Study question Do extracellular vesicles (EVs) mirror the cyclic physiological changes in endometrial tissue, reflecting maturation along entire menstrual cycle? Summary answer Multi-omics data highlights importance of EVs during mid-secretory phase and cargo reflects state tissue throughout cycle. What is known already Extracellular isolated from uterine fluid (UF) have been characterized for their pivotal role embryo-maternal communication, particularly context microRNAs (miRNAs)...