A5028235293- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Estrogen and related hormone effects
- Phytoestrogen effects and research
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Hepatitis B Virus Studies
- Bone Metabolism and Diseases
- Ginger and Zingiberaceae research
- Cancer, Lipids, and Metabolism
- Spectroscopy and Chemometric Analyses
- Food Quality and Safety Studies
- Bioactive Compounds and Antitumor Agents
- Lipid metabolism and biosynthesis
- Genomics, phytochemicals, and oxidative stress
Hong Kong Polytechnic University
2014-2024
Shenzhen Polytechnic
2017-2022
State Council of the People's Republic of China
2019
Hong Kong Baptist University
2005-2017
MedStar Harbor Hospital
1970
Over recent decades sulfur fumigation has been becoming abused in processing some freshly harvested Chinese medicinal herbs, although it is questioned whether can result changes efficacy and safety of the herbs. One herbs commonly processed by Codonopsis Radix (Dangshen). A report showed that lobetyolin content sulfur-fumigated Dangshen was lower than air-dried Dangshen. Whereas there no investigation designed to compare chemical profiles In present study, a rapid versatile...
Tumorigenesis involves constant communication between tumor cells and neighboring normal such as adipocytes. The canonical function of adipocytes is to store triglyceride release fatty acids for other tissues. This study was aimed find out if promoted melanoma cell growth investigate the underlying mechanism. Here we isolated from inguinal adipose tissue in mice co-cultured with cells. We found that had higher lipid accumulation compared mono-cultured melanoma. In addition, fluorescently...
Cycloartane triterpenoids exhibited anticancer effects. This study aims to identify any potential novel cycloartane from Cimicifuga foetida L. rhizome (Sheng ma) and the mode of actions.Cycloartane were isolated C. by a series column chromatography identified IR, MS NMR. Their effects on several human cancer cell lines, MCF-7, HepG2, HepG2/ADM, HeLa, PC3, normal mammary epithelial cells MCF10A investigated colony formation MTT assays. Morphological analysis apoptosis induction was performed...
Inflammatory bowel disease (IBD) is a chronic progressive intestinal inflammatory disease, characterized by an altered gut microbiota composition and accompanying alterations in circulatory bile acids. Increasing evidence supports the beneficial effect of probiotics intake on health. Introduction to intestines can modulate turn regulate host immune system modify response. Probiotics also improve barrier function exhibit positive impact physiological pathological conditions via...
The ways in which agricultural soils are managed influence the production and emission of nitrous oxide (N 2 O). A field study was undertaken 2003, 2004, 2005 to quantify evaluate N O from tilled no-till under corn (Zea maysL.) soybeans (Glycine max L. Merr) Ontario. Overall, lowest driest coolest 3 yr. In significantly larger annual attributed an episode very high following application fertilizer during a period wet weather. That loss by occurred only large long-lasting (~4 wk) confirms...
Browning is the process of increasing number brite cells, which helps to increase energy expenditure and reduce obesity. Consumption natural non-toxic herbal extracts that possess browning effect an attractive anti-obesity strategy. In this study, we examined cinnamon extract. We found extract (CE) induced typical brown adipocyte multiocular phenotype in 3T3-L1 adipocytes. The treatment also increased adipocytes markers reduced white ex vivo studies, CE subcutaneous isolated from db/db mice...
Abstract Pinelliae Rhizoma (PR) is a commonly used Chinese medicinal herb, but it has been frequently reported about its toxicity. According to the traditional medicine theory, processing can reduce toxicity of herbs. Here, we aim determine if reduces raw PR, and explore underlying mechanisms PR-induced toxicities toxicity-reducing effect processing. Biochemical histopathological approaches were evaluate processed PR. Rat serum metabolites analyzed by LC-TOF-MS. Ingenuity pathway analysis...
ABSTRACT Introduction Semen Cassiae (SC), a traditional Chinese herbal medicine for the treatment of various diseases, is known to contain active anthraquinone ingredients. However, since content some anthraquinones too low, previous analytical methods only allow quantitation few or hydrolysis step has be included in sample preparation. A rapid and accurate method examine as many possible SC would desirable. Objective To develop rapid, sensitive high‐performance liquid chromatography–diode...
Abstract Schisandrin B (SchB) is one of the most abundant bioactive dibenzocyclooctadiene derivatives found in fruit Schisandra chinensis . Here, we investigated potential therapeutic effects SchB on non-alcoholic fatty-liver disease (NAFLD). In lipidomic study, ingenuity pathway analysis highlighted palmitate biosynthesis metabolic liver samples SchB-treated high-fat-diet-fed mice. Further experiments showed that treatment reduced expression and activity fatty acid synthase, expressions...
Chronic hepatitis B viral (HBV) infection remains a high underlying cause for hepatocellular carcinoma (HCC) worldwide, while the genetic mechanisms behind this remain unclear. This study elucidated contributing to tumor development induced by HBV X (HBx) gene of predominantly Asian genotype and its common HBx variants. To compare potential tumorigenic effects K130M/V131I (Mut) wild-type (WT) on HCC, Sleeping Beauty (SB) transposon system was used deliver Mut WT into livers...
Our previous study revealed that the bone anabolic effects of lignan-rich fraction (SWCA) from Sambucus williamsii Hance was involved in modulating metabolism tryptophan vivo and inhibiting serotonin (5-HT) synthesis vitro. This aimed to determine how SWCA modulates via vivo. The were evaluated by using 4-month-old Sprague-Dawley (SD) ovariectomized rats. serum levels 5-HT kynurenine, protein expressions hydroxylase 1 (TPH-1) TPH-2, genes proteins related signaling pathway as well gut...
Abstract The current approaches to the quality control of herbal medicines are either compound-oriented or pattern-oriented, former targeting specific components with some known chemical properties and latter all detectable components. marker approach uses compounds molecular structures, while multi-compound both structures those partial information e.g. retention times, mass spectra ultraviolet spectra. Apart from chromatographic techniques, new techniques such as oscillating...
Two new diarylheptanoids, 1-(3',5'-dihydroxy-4'-methoxyphenyl)-7-phenyl-3-heptanone (1) and 1-(2',4'-dihydroxy-3'-methoxyphenyl)-7-(4″-methoxyphenyl)-3-heptanone (2), along with known diarylheptanoid yakuchinone A (3), five flavanoids, tectochrysin (4), chrysin (5), izalpinin (6), kaempferol 7, 4'-dimethyl ether (7), kaempferide (8) were isolated from the fruits of Alpinia oxyphylla Miq. Their structures determined by means spectroscopic methods. Antioxidant activities all compounds...
Background The aim of this study is to reveal the clinical and histopathological features HBsAg-positive HBeAg-positive chronic hepatitis B infected patients with high level HBV DNA, from 17 hospitals medical centres in China, alanine aminotransferase levels within lower region normal range versus those upper investigate risk factors for requirement treatment through examination liver biopsy. Methods Liver biopsy was performed on DNA 455 infection persistently level. necroinflammation...
Patchoulic oil, the volatile oil of Pogostemon cablin (BLANCO) BENTH. and Chinese crude drug Herba Pogostemonis, is widely used in cosmetic oral hygiene industries. alcohol commonly as an indicator for quality assessment dried P. cablin. However, complexity herbal constituents makes it difficult using conventional gas chromatography (GC) analytical purpose. The present study established accurate, sensitive reproducible method patchouli herb based on patchoulic content. A...