A5023595978- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Peroxisome Proliferator-Activated Receptors
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Neurofibromatosis and Schwannoma Cases
- Nerve injury and regeneration
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Chromatin Remodeling and Cancer
- Bacteriophages and microbial interactions
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- EEG and Brain-Computer Interfaces
- Endoplasmic Reticulum Stress and Disease
- Pharmaceutical studies and practices
- Cancer-related gene regulation
- Muscle Physiology and Disorders
- Obstructive Sleep Apnea Research
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
Hong Kong Polytechnic University
2015-2023
Shenzhen Polytechnic
2018-2019
Montreal Clinical Research Institute
2016
University of Minnesota
2015
Masonic Cancer Center
2015
Chinese University of Hong Kong
2015
University of Southern California
2004
Chronic hepatitis B viral (HBV) infection remains a high underlying cause for hepatocellular carcinoma (HCC) worldwide, while the genetic mechanisms behind this remain unclear. This study elucidated contributing to tumor development induced by HBV X (HBx) gene of predominantly Asian genotype and its common HBx variants. To compare potential tumorigenic effects K130M/V131I (Mut) wild-type (WT) on HCC, Sleeping Beauty (SB) transposon system was used deliver Mut WT into livers...
Non-alcoholic fatty liver disease (NAFLD) is becoming an epidemic in adults and children worldwide. Importantly, there are currently no approved treatments available for NAFLD. This study aims to investigate the potential applications of sodium tanshinone IIA sulfonate (STS) on improving NAFLD condition using both vitro vivo approaches. The results showed that STS markedly inhibited lipid accumulation oleic acid (OA) palmitic (PA) treated HepG2 primary immortalized human hepatic (PIH) cells....
Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated as a potential oncogene in liver cancer. However, knockout studies have shown it to be transcriptional repressor of the alpha-foetoprotein (Afp) gene adult liver, reduced levels ZBTB20 allow for upregulation AFP with increased tumour severity certain cases hepatocellular carcinoma (HCC). As there are many discrepancies literature regarding its role tumourigenesis, aim this study was elucidate HCC tumourigenesis.A reverse...
Abstract Malignant peripheral nerve sheath tumors ( MPNST s) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. s can occur either sporadically or in association the neurofibromatosis type 1 NF 1) syndrome. Importantly, activation RAS / RAF MEK ERK , PI 3K/ AKT mTOR WNT CTNNB signaling pathways has been reported both 1‐related late‐stage sporadic s. In this study, we found that DAW 22, a natural sesquiterpene...
Scoring sleep stages is an essential procedure for the diagnosis of sleeping disorders. Conventional staging a laborious and costly requiring multimodal biological signals expert assessment. There has always been demand approaches which can exempt need to going through diagnostic procedures under specialized facilities enable automated staging. Herein, high‐performance multitask learning model enabling high‐accuracy using heart rate data reported. The proposed algorithm exhibits superior...
Abstract The neuromuscular junction (NMJ) consists of three components, namely presynaptic motor neurons, postsynaptic muscle fibers and perisynaptic Schwann cells (PSCs). role (SCs) in regulating NMJ structural functional development remains unclear. In this study, mice with conditional inactivation neurofibromin 1 (Nf1) phosphatase tensin homolog (Pten), specifically SCs, resulted delayed maturation that led to growth, recapitulating the muscular dystrophy condition observed human...
Various molecular subclasses of hepatocellular carcinoma (HCC) exists, with many novel cooperating oncogenes and tumor suppressor genes involved in its tumorigenesis. The emerging importance WNT signaling HCC has been established. However, the intricate genetic mechanisms this complex pathway remains to be elucidated. Importantly, while some have identified, there are still unknown associated catenin beta 1 (CTNNB1)-induced HCC. Mutations both required for emergence CRISPR/Cas9 system...
Abstract Metastases account for most cancer-related deaths as a result of primary cancer spreading to distant sites. Amongst human hepatocellular carcinoma (HCC), there is drastic decrease in the survival rate observed patients with early stage localized HCC late metastasis-associated HCC. Importantly, genetic mechanisms associated remains elusive. Therefore, forward screen mice using Sleeping Beauty (SB) insertional mutagenesis system was developed identify genes Truncated version epidermal...