Glucagon-like peptide-1 (GLP-1) is an incretin hormone known to stimulate glucose-dependent insulin secretion. The GLP-1 receptor agonist, exendin-4, has similar properties and currently in clinical use for type 2 diabetes mellitus. As exendin-4 confer cardioprotection after myocardial infarction, this study was designed assess the neuroprotective effects of against cerebral ischemia–reperfusion injury. Mice received a transvenous injection 60-minute focal ischemia. Exendin-4-treated vehicle...

<h3>BACKGROUND AND PURPOSE:</h3> The Low-Profile Visualized Intraluminal Support Device comprises a small-cell nitinol structure and single-wire braided stent that provides greater metal coverage than previously reported intracranial stents, as well assumed strong susceptibility artifacts. This study aimed to assess the benefits of non-contrast-enhanced MRA by using Silent Scan (Silent MRA) for anterior circulation aneurysms treated with stents. <h3>MATERIALS METHODS:</h3> Thirty-one stents...

Flow diverters (FDs) have been developed for intracranial aneurysms difficult to treat with conventional endovascular therapy and surgical clipping. We reviewed 94 patients 100 large or giant unruptured internal carotid artery (ICA) treated Pipeline embolization device (PED) from December 2012 June 2017 at Juntendo University Hospital. The patients' mean age was 63.4 years (range, 19-88), there were 90 women 89.4%. Aneurysm locations were: C4 (45), C3 (4), C2 (51) in ICA segments. Mean...

<h3>BACKGROUND AND PURPOSE:</h3> The flow-diverter device has been established as a treatment procedure for large unruptured intracranial aneurysms. purpose of this study was to compare the usefulness Silent MR angiography and time-of-flight MRA assess parent artery embolization state aneurysm after placement. <h3>MATERIALS METHODS:</h3> Seventy-eight large, internal carotid aneurysms in 78 patients were subjects study. After 6 months treatment, they underwent follow-up digital subtraction...

Flow diverter (FD) therapy using Pipeline embolization device (PED) has become an important alternative to treat internal carotid artery (ICA) aneurysms. Herein, we report the long-term outcome for 3 years after FD PED ICA aneurysms in Japan. The patients who underwent angiographical and/or clinical follow-up of large or giant unruptured from December 2012 at our university hospital are subjects this study. We retrospectively reviewed in- and outpatients' medical charts, written operative...

Intracranial aneurysms are extremely rare in infants, and to our knowledge only seven infants treated for ruptured spontaneous dissecting have been reported. Good outcomes achieved with endovascular treatment of infantile aneurysm. We the a one-month-old girl aneurysm located anterior communicating artery, unique radiological changes that were observed during perioperative follow-up periods. These suggest blood coagulation fibrinolytic response play part repair healing processes aneurysms....

There have recently been reports of patients who developed postprocedural symptoms or alterations due to delayed foreign body embolisms observed in imaging findings. Polymer coating devices described as a possible cause embolisms, manifesting granulomatous responses and exhibiting characteristic In four 4,025 underwent coil embolization our hospital its affiliated facilities, similar findings were observed. Delayed lesions appeared between 1 month year after the procedures. was extensive...

Abstract BACKGROUND Safe and appropriate harvesting of the donor scalp vessel is first key procedure in any type bypass surgery. OBJECTIVE To use so-called bipolar cutting method to harvest arteries, which arteries are skeletonized with cautery. The surgical preparation equipment described. results histological assessment presented. METHODS generator was set at 50 Malis units coagulation mode. Under microscope, surrounding tissue artery divided coagulated forceps. completely provide adequate...

Animal models of intracranial aneurysms are important for training surgeons and creating innovative endovascular treatment. Swine have physical dimensions close to those humans so widely used in cardiology research. swine as had difficulty maintaining long-term aneurysm patency. We present a model that may allow researchers follow outcomes after treatment.We developed terminal (n = 3) using vein pouch an end-to-side anastomosis the right carotid artery. anastomosed left artery end side,...

After coil embolization, recanalization in cerebral aneurysms adversely influences long-term prognosis. Proliferation of endothelial cells on the surface may reduce incidence and further improve outcomes after embolization. We aimed to map expression proliferating tissue over aneurysmal orifice define temporal profile growth a swine experimental aneurysm model. compared spontaneous thrombosis with those embolization using histological morphological techniques. In that we not coiled, was...

Purpose Antiplatelet therapy initiated before flow diverter placement is effective for the prevention of ischemic complications. However, effectiveness oral anticoagulant treatment unclear. This retrospective study evaluated complications and obliteration rates after in patients taking anticoagulants. Methods A total 155 cases were treated by Pipeline Flex unruptured large giant cerebral aneurysms our hospital between October 2015 June 2019. The groups 8 anticoagulants operation 147 not...

A delayed aneurysm rupture after flow diverter therapy is a rare but serious complication. Due to the anatomical specificity, of carotid cavernous may cause direct fistula (dCCF). We present novel therapeutic approach for treatment dCCF using Pipeline embolization device (PED). An 86-year-old woman suffered from PED embolization. microcatheter was advanced through transvenous into sinus (CS) and further inserted sac via point. Coil both small part CS adjacent fistulous site could achieve not...

Background Flow diversion with the Pipeline embolization device (PED) is a widely accepted treatment modality for aneurysm occlusion. Previous reports have shown no recanalization of aneurysms on long-term follow-up once total occlusion has been achieved. Case description We report 63-year-old male who had large internal carotid artery cavernous segment aneurysm. Treatment PED resulted in complete However, angiography at four years revealed recurrence due to disconnection two PEDs placed...

Objective: Distal anterior cerebral artery (DACA) aneurysms are rare, accounting for 1-9% of all intracranial aneurysms.These aneurysms, however, challenging to treat using surgical clipping and endovascular coiling.Nevertheless, according recent reports, advances in therapy devices technologies have produced better results.We therefore aimed assess the current status treatment DACA aneurysms.Methods: Between 2004 2017, we treated 47 consecutive patients with 49 coiling at Juntendo...

Lateral wall paraclinoid aneurysms (LPA) are a rare type of aneurysm located on the lesser curve side internal carotid artery (ICA) bend, at level anterior clinoid process. The objective this study was to assess influence flexion ICA morphology and outcome endovascular treatment. Between 2003 2018, we treated 643 cases unruptured with therapy in our institution. Of those cases, projecting laterally preoperative angiography were defined as LPA. degree bending (ICA angle) measured...

A 2-year-old girl who had previously been treated for stage IV intra-abdominal neuroblastoma presented with headache and vomiting. Computed tomography (CT) showed hematoma in the right temporal lobe. Two months previously, she suffered a generalized seizure but brain CT was unremarkable. The removed completely without evidence of vascular anomaly or tumor. Four weeks after surgery, magnetic resonance imaging gadolinium developing mass lesion bed. second operation tumor removal confirmed rare...

Among all stents available for neuroendovascular therapy, the low-profile visible intraluminal support stent bears highest metal coverage ratio. We deployed a with delivery wire or/and microcatheter system push action to shorten and thus achieve flow diversion effect. report our single-institution experience use of intentionally shortened deployment (shortening group) non-shortened (non-shortening unruptured intracranial aneurysms.We retrospectively reviewed medical records 130 patients 131...

Objective: Pipeline Embolization Device (PED; Medtronic, Minneapolis, NM, USA) is the first and currently only flow diversion device approved by Ministry of Health, Labour Welfare in Japan. The PED able to embolize unruptured intracranial aneurysm (UIA) due disruption blood into sac while preserving normal parent surrounding branch vessels. One drawbacks embolization require coil when aneurysms are deemed be high-risk delayed rupture.