A5054713555- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Cerebral Venous Sinus Thrombosis
- Kruppel-like factors research
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Ocular Oncology and Treatments
- Microtubule and mitosis dynamics
- Spinal Fractures and Fixation Techniques
- Restraint-Related Deaths
- Epilepsy research and treatment
- Periodontal Regeneration and Treatments
- Spondyloarthritis Studies and Treatments
- CRISPR and Genetic Engineering
- Neurofibromatosis and Schwannoma Cases
- Oral and Maxillofacial Pathology
- Child Abuse and Related Trauma
- Spine and Intervertebral Disc Pathology
- Cancer Mechanisms and Therapy
Juntendo University Urayasu Hospital
2009-2022
University of Toronto
2018-2021
Neurological Surgery
2021
St. Michael's Hospital
2019-2021
Hospital for Sick Children
2014-2020
SickKids Foundation
2014-2020
Juntendo University
2008-2020
Queen's University
2018
Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in adults. Despite current treatment modalities, such as surgical resection followed by chemotherapy radiotherapy, only modest improvements median survival have been achieved. Frequent recurrence invasiveness of GBM are likely due to resistance glioma stem cells conventional treatments; therefore, novel alternative strategies desperately needed. Recent advancements molecular biology gene technology...
// Hidehiro Okura 1, 2 , Brian J. Golbourn 1 Uswa Shahzad Sameer Agnihotri Nesrin Sabha 7 Jonathan R. Krieger 8 Carlyn A. Figueiredo Alan Chalil Natalie Landon-Brace Alexandra Riemenschneider Hajime Arai Christian Smith Songli Xu 5 Stefan Kaluz 4, 6 Adam I. Marcus 5, Erwin G. Van Meir James T. Rutka 3 The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Peter Gilgan Centre Learning, Toronto, Ontario, M5G 0A4, Canada Department of Neurosurgery, Juntendo...
We aimed to clarify the mechanisms of neural plasticity involved in language. hypothesized that alterations which occur bilinguals could reflect acquisition a second language and simulate related compared spatial characteristics story listening-related hemodynamic modulations subcortical fiber networks between monolinguals bilinguals. Participants were Japanese Japanese-English whose first was Japanese. divided into early late depending on whether age before after 7 years age. applied...
Summary Objective Polymicrogyria ( PMG ) is a common malformation of cortical development. Many patients with will have medically refractory epilepsy but the role surgery unclear. The objective this study was to assess efficacy surgical resection/disconnection in achieving seizure control pediatric . Methods A retrospective review children undergoing for between 2002 and 2017 at Hospital Sick Children Toronto, Canada, performed. Results total 12 aged 6 months 17.8 years (median 8.8 years)...
The tumor-suppressor genes TSC1 and TSC2 are mutated in tuberous sclerosis, an autosomal dominant multisystem disorder. gene products of form a protein complex that inhibits the signaling mammalian target rapamycin complex1 (mTORC1) pathway. mTORC1 is crucial molecule regulation cell growth, proliferation survival. When TSC1/TSC2 not functional, uncontrolled activity accelerates cycle triggers tumorigenesis. Recent studies have suggested also regulate activities Rac1 Rho, members Rho family...
A 61-year-old man presented with a rare pleural malignant mesothelioma of the spine manifesting as progressive weakness bilateral lower extremities, numbness in body and both legs, dysfunction bladder bowel. He had previous occupational exposure to asbestos while working at car repair shop undergone right panpleuropneumonectomy under diagnosis sarcomatous type space. Magnetic resonance imaging gadolinium showed an enhanced intramedullary tumor T4 level. Operative findings disclosed clouded...
Genetic crossing experiments were performed between tuberous sclerosis‐2 ( Tsc2 ) KO and expressed in renal carcinoma Erc mice to analyze the function of / mesothelin gene carcinogenesis. We found number size tumors significantly less +/−; −/− than +/+ +/− mice. Tumors from exhibited reduced cell proliferation increased apoptosis, as determined by proliferating nuclear antigen (Ki67) TUNEL analysis, respectively. Adhesion collagen‐coated plates vitro was enhanced ‐restored cells decreased...
Recent studies indicated that the tuberous sclerosis 2 (TSC2) gene product, tuberin, regulates Rac1 activity. However, underlying mechanism by which tuberin activity has not been clearly elucidated to date. To better understand molecular link between function and Rac1, we characterized distribution of in mouse Tsc2-deficient renal tumor cells using restoration experiments with wild-type tuberin. was significantly higher tuberin-expressing compared control cells. Further, activation induced...
An 85-year-old female presented with a 3-month history of worsening hyperlacrimation and blurred vision following blunt head injury. Her past medical was unremarkable. blood examination identified no abnormal findings. Neuroophthalmological inspection revealed extraocular movement disorder mild exophthalmos on the affected side. visual acuity not disturbed. Neuroimaging showed cystic mass located extraconally in superolateral compartment anterior orbit, without enhancement by contrast...
Arachnoid cysts arising in the quadrigeminal cistern (ACQCs) are uncommon. A 68-year-old woman presented with an unsteady gait, facial spasm, and cerebellar ataxia. Non-contrast head computed tomography showed a cystic mass centered accompanying ventriculomegaly. On MRI, cyst appeared hypointense on T1- hyperintense T2-weighted sequence. There was no restricted diffusion diffusion-weighted imaging. The cerebral aqueduct obstructed prepontine narrowed. left vertebral artery (VA) coursed...
A 2-year-old girl who had previously been treated for stage IV intra-abdominal neuroblastoma presented with headache and vomiting. Computed tomography (CT) showed hematoma in the right temporal lobe. Two months previously, she suffered a generalized seizure but brain CT was unremarkable. The removed completely without evidence of vascular anomaly or tumor. Four weeks after surgery, magnetic resonance imaging gadolinium developing mass lesion bed. second operation tumor removal confirmed rare...
A 90-year-old, non-hypertensive woman presented gait disturbance followed by falls. She had developed a lacunar infarction in the right frontal lobe 1 month previously that subsequently resulted subtle motor weakness left lower extremity. At presentation, patient showed upper and extremities with normal findings on blood test. Cranial computed tomography (CT) revealed subcortical hemorrhage anterior part of was accompanied perilesional edema. In addition, two small subdural hematomas,...
Penetrating head trauma (PHT) includes any traumatic injury where an object pierces the skull and breaches dural membrane surrounding brain. PHTs are less prevalent than blunt injuries. However, they often have more complex damage, worse prognosis, higher rates of morbidity mortality. An 83-year-old man fell at his home hit on right side toward a shoji (a Japanese-style paper sliding door). He reported to emergency room following day with family. had small wound before ear, which was sutured...
Many patients with primary vitreoretinal lymphoma (PVRL) exhibit central nervous system (CNS) involvement either at the diagnosis or during follow-up. The prognosis in of PVRL relapsed refractory CNS remains extremely poor. We herein report a patient who had recurrence spinal cord despite receiving high-dose methotrexate-based chemotherapy and whole-brain radiotherapy. surprisingly responded to tirabrutinib temporarily. believe that this case suggests utility new target therapy.
Endodermal cyst (EC) is a benign tumor that can arise along the craniospinal axis. Infrequently, ECs undergo malignant transformation. A 43-year-old man presented with numbness in right arm, leg and occipitalgia. MRI revealed multicystic, intradural extramedullary at C2 enhancement ventral surface of spinal cord. Blood test showed an abnormal increase serum carbohydrate antigen 19-9 (CA 19-9) level. Systemic positron emission tomography-computed tomography was normal. He underwent total...
Abstract Introduction: Malignant astrocytoma is a highly proliferative and invasive neoplasm that infiltrates diffusely into regions of normal brain rendering total surgical extirpation impossible effective local radiation therapy difficult. Conventional chemotherapy frequently fails because most agents administered systemically will not cross the blood-brain barrier. Despite recent reports which have shown 2-month survival advantage when adjuvant temozolomide used for glioblastoma...
Dural arteriovenous fistula (dAVF) of the anterior cranial fossa is an aggressive entity with a high risk intracranial hemorrhage. A 38-year-old woman presented to our institution nasal obstruction and discharge. Computed tomography (CT) scans performed for suspected sinusitis revealed erosion crista galli predominantly on left side. The frontal ethmoidal sinuses adjacent were clear did not communicate galli. Contrast computed ectatic vessels galli, coursing cortical surface. Cerebral...
Calvarial erosion is an infrequent manifestation associated with oligodendrogliomas, astrocytomas, dysembryoplastic neuroepithelial tumors, astroblastomas, glioblastomas, and meningiomas. Anaplastic ependymoma (AE), a rare malignant form of ependymoma, commonly results in poor prognosis. During the last 12 years, six patients were diagnosed supratentorial ependymomas. All them AEs extraventricular location identified right parietal, left frontal lobes, respectively. Three them, 7-, 15,...
A 6-month-old, previously healthy boy presented with poor feeding and vomiting for 2 weeks. At presentation, his left supraorbital vein was found to engorge considerably. cranial computed tomography (CT) scan revealed a large cyst in the posterior fossa prominent superior ophthalmic (SOV). Magnetic resonance imaging delineated well-demarcated markedly compressing right cerebellar hemisphere. The patient underwent microscopic fenestration of wall through lateral suboccipital craniotomy. wall,...
A 69-year-old woman sustained progressive proptosis for 2 months. The patient had undergone surgery resection of colon cancer 10 years prior, which was considered to have been completely cured 5 prior. She also aware a hard mass in her left breast, but it untreated. Furthermore, she experienced back pain month. Blood examination revealed an elevated level serum carcinoembryonic antigen, at 17.4 ng/mL (< 5). Computed tomography (CT) tumor occupying the superolateral part right orbit, with...
Meningeal hemangiopericytoma (HPC) is an infrequent but distinct entity affecting the craniospinal axis. A previously healthy 48-year-old man sustained a gradually progressing motor weakness in left lower extremity. CT showed hyperdense mass right frontal lobe. On MRI, it was 29 × 30 36 mm dimension, appeared isointense on T1 and hyperintense T2, intensely enhanced with erosive changes inner table adjacent to tumor. The patient underwent tumor resection. Reflection of bone flap revealed...