A5034086343- Vascular Malformations Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Air Quality and Health Impacts
- Cerebrospinal fluid and hydrocephalus
- Adipose Tissue and Metabolism
- Neuroendocrine Tumor Research Advances
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Child Abuse and Related Trauma
- Restraint-Related Deaths
- Cytomegalovirus and herpesvirus research
- Combustion and Detonation Processes
- Traumatic Ocular and Foreign Body Injuries
- Vascular Malformations and Hemangiomas
- Iron and Steelmaking Processes
- Traumatic Brain Injury and Neurovascular Disturbances
- Teratomas and Epidermoid Cysts
- Neurosurgical Procedures and Complications
- Vehicle emissions and performance
- Chromatin Remodeling and Cancer
- Cardiovascular Disease and Adiposity
- Toxoplasma gondii Research Studies
- Energy and Environment Impacts
Juntendo University Shizuoka Hospital
2023-2024
Yamagata University
2024
Neurological Surgery
2021
Kumamoto University
2010-2021
Juntendo University Urayasu Hospital
2021
Saga University
2003-2020
National Institutes of Health
2011
Tokai University
2011
RIKEN Advanced Science Institute
2011
Juntendo University
1974-1990
The induction of beige adipogenesis within white adipose tissue, known as "browning", has received attention a novel potential anti-obesity strategy. expression some characteristic genes including PR domain containing 16 is induced during the browning process. Although acetate been reported to suppress weight gain in both rodents and humans, its effects on tissue have not fully characterized. We examined treatment 3T3-L1 cells obese diabetic KK-Ay mice. mRNA levels involved adipocyte...
MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally regulate gene expression and have been shown to participate in almost every cellular process. Several miRNAs recently implicated glucose metabolism, but the roles of insulin-resistant conditions, such as obesity or type 2 diabetes, largely unknown. Herein, we focused on miR-222, which was increased livers high fat/high sucrose diet-fed mice injected with gold thioglucose (G+HFHSD). Overexpression miR-222 primary mouse...
Ectopic adrenocorticotropic hormone (ACTH) production by the pancreatic neuroendocrine tumor (p-NET) is relatively rare, and patients with this show poor prognosis. In study, we present case of a 64-year-old woman who presented ectopic ACTH syndrome due to p-NET multiple liver metastases. Computed tomography revealed that she had masses in solid mass head pancreas. Endocrinological examinations markedly elevated plasma (735.0 pg/mL) cortisol (34.7 μg/dL) levels associated hypokalemia (2.7...
Unique cytolytic degeneration of keratinocytes adjacent to Langerhans cells was observed in five cases pityriasis rosea (Gilbert). In the area, normal keratinocyte structures were absent except for free ribosomes. addition, a similar part enveloped by elongated dendrites cell and detected within its cytoplasm. The significance these findings is discussed with respect anticytoplasmic antibodies sera patients rosea.
Heat shock protein 72 (HSP72) is a major inducible molecule in the heat response that enhances intracellular stress tolerance. Decreased expression of HSP72 observed type 2 diabetes, which may contribute to development insulin resistance and chronic inflammation. We used knockout (HSP72-KO) mice investigate impact on glucose metabolism endoplasmic reticulum (ER) stress, particularly liver. Under high-fat diet (HFD) condition, HSP72-KO showed intolerance, resistance, impaired secretion,...
The age-related incidence of spontaneously occuring neoplastic and non-neoplastic lesions in untreated F-344/Jcl rats, used as controls carcinogenicity testing, were studied from the histological examination tissues 469 males 354 females. spontaneous tumors was 83.2% 71.2% most common neoplasms leukemia (males : 24.3%, females 24.0%), pituitary adenoma 16.0%, 45.2%), pheochromocytoma 14.7% 7.3%, testicular interstitial cell tumor 79.1%), uterine endometrial stromal polyp(females 16.4%)....
In hypertensive patients, primary aldosteronism (PA) is the most prevalent type of secondary hypertension, and screening for PA has become very important. Calcium channel blockers (CCB) are widely used to treat but CCBs stimulate plasma renin activity (PRA) increase aldosterone concentration (PAC), both which in PA. The aim this study was determine whether newly introduced CCB, azelnidipine, affects PRA PAC.40 patients were treated with 16 mg azelnidipine 4 weeks.Azelnidipine treatment...
All cloned sialyltransferases from vertebrates are classified into four subfamilies and characterized as having type II transmembrane topology. The catalytic domain has highly conserved motifs known sialylmotifs. Besides sialylmotifs, each family several unique cysteine (Cys) residues mainly in the domain. number loci of amino acids, however, differ with subfamily, suggesting that Cys-residues and/or disulphide linkages they make may contribute to linkage specificity. Using Matrix Assisted...
Abstract is not availeble.
Arachnoid cysts arising in the quadrigeminal cistern (ACQCs) are uncommon. A 68-year-old woman presented with an unsteady gait, facial spasm, and cerebellar ataxia. Non-contrast head computed tomography showed a cystic mass centered accompanying ventriculomegaly. On MRI, cyst appeared hypointense on T1- hyperintense T2-weighted sequence. There was no restricted diffusion diffusion-weighted imaging. The cerebral aqueduct obstructed prepontine narrowed. left vertebral artery (VA) coursed...
Nonalcoholic fatty liver disease (NAFLD) is often accompanied by metabolic disorders such as syndrome and type 2 diabetes (T2DM). Heat shock response (HSR) one of the most important homeostatic abilities but deteriorated chronic insults. (HS) with an appropriate mild electrical stimulation (MES) activates HSR improves abnormalities including insulin resistance, hyperglycemia inflammation in disorders. To analyze effects HS + MES treatment on NAFLD biomarkers, three cohorts healthy men (two...
Penetrating head trauma (PHT) includes any traumatic injury where an object pierces the skull and breaches dural membrane surrounding brain. PHTs are less prevalent than blunt injuries. However, they often have more complex damage, worse prognosis, higher rates of morbidity mortality. An 83-year-old man fell at his home hit on right side toward a shoji (a Japanese-style paper sliding door). He reported to emergency room following day with family. had small wound before ear, which was sutured...
Sustainable energy societies demand rechargeable batteries using ubiquitous-material electrodes of geopolitical-risk-free elements. We aim to develop low-overpotential oxygen-evolution-reaction (OER) catalysts that suppress carbon corrosion gas-diffusion (GDEs) realize two-electrode Zn-air (r-ZABs). Herein, single-walled-carbon-nanotube (SWNT) thin films are used as a scaffold for benchmark OER catalyst, doping-free NiFe-layered double hydroxide (NiFeLDHs), operating in r-ZABs alkali aqueous...
Dural arteriovenous fistula (dAVF) of the anterior cranial fossa is an aggressive entity with a high risk intracranial hemorrhage. A 38-year-old woman presented to our institution nasal obstruction and discharge. Computed tomography (CT) scans performed for suspected sinusitis revealed erosion crista galli predominantly on left side. The frontal ethmoidal sinuses adjacent were clear did not communicate galli. Contrast computed ectatic vessels galli, coursing cortical surface. Cerebral...
Calvarial erosion is an infrequent manifestation associated with oligodendrogliomas, astrocytomas, dysembryoplastic neuroepithelial tumors, astroblastomas, glioblastomas, and meningiomas. Anaplastic ependymoma (AE), a rare malignant form of ependymoma, commonly results in poor prognosis. During the last 12 years, six patients were diagnosed supratentorial ependymomas. All them AEs extraventricular location identified right parietal, left frontal lobes, respectively. Three them, 7-, 15,...
A 6-month-old, previously healthy boy presented with poor feeding and vomiting for 2 weeks. At presentation, his left supraorbital vein was found to engorge considerably. cranial computed tomography (CT) scan revealed a large cyst in the posterior fossa prominent superior ophthalmic (SOV). Magnetic resonance imaging delineated well-demarcated markedly compressing right cerebellar hemisphere. The patient underwent microscopic fenestration of wall through lateral suboccipital craniotomy. wall,...
A 69-year-old woman sustained progressive proptosis for 2 months. The patient had undergone surgery resection of colon cancer 10 years prior, which was considered to have been completely cured 5 prior. She also aware a hard mass in her left breast, but it untreated. Furthermore, she experienced back pain month. Blood examination revealed an elevated level serum carcinoembryonic antigen, at 17.4 ng/mL (< 5). Computed tomography (CT) tumor occupying the superolateral part right orbit, with...
A 6-month-old, previously healthy boy hit the right frontal region of his head against corner a plastic toy box. At presentation, small area with scalp discoloration was noted in region. Head computed tomography at level revealed an intracranial hematoma, 5 mm maximal thickness, below coronal suture. In addition, there were bony bridges connecting and parietal bones. Furthermore, linear crack found diploe bone contact Cerebral MRI confirmed hyperintensity between inner tables. We assumed...