A5047549203- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Reproductive Biology and Fertility
- Circular RNAs in diseases
- Carbon and Quantum Dots Applications
- Analytical Chemistry and Sensors
- Carbohydrate Chemistry and Synthesis
- MicroRNA in disease regulation
- Porphyrin and Phthalocyanine Chemistry
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
Manipal Academy of Higher Education
2023
Rajiv Gandhi Centre for Biotechnology
2019-2023
Indian Institute of Science Bangalore
2023
Photodynamic therapy (PDT) emerged as a promising cancer therapeutic technique due to the prospect of triggering and controlling drug action with light, which will reduce detrimental side effects traditional chemotherapy. In recent years, in PDT design, progressive approaches such use nanocarriers targeted delivery systems have been achieved improve bioavailability efficacy therapy. Herein, we report synthesis, photophysical, photobiological properties graphene oxide quantum dot (GQD)–BODIPY...
The major challenge in photodynamic therapy (PDT) is to discover versatile photosensitizers (PSs) that possess good solubility biological media, enhanced singlet oxygen generation efficacy, and activity. Working this direction, we synthesized a picolylamine-functionalized porphyrin conjugate, compound 1, its zinc complex 2. Compound 1 forms spherical structures methanol, whereas 2 exhibited vesicular structures. Compared the existing PSs like foscan photofrin, high efficiency triplet quantum...
With an objective to develop efficient photosensitizers cancerous tissues, we synthesized two novel biocompatible sensitizers based on aza-BODIPYs incorporated with heavy atoms and biotin moieties. The bioconjugates DPR2a DPR2b exhibited a favorable absorption range (600–750 nm) excellent triplet-state quantum yields (up 79%) singlet oxygen generation 75%). In vitro photobiological investigations employing MDA-MB-231 breast cancer cell lines rapid cellular uptake, negligible dark toxicity,...
The stringent regulation of RAGs (Recombination activating genes), the site-specific endonuclease responsible for V(D)J recombination, is important to prevent genomic rearrangements and chromosomal translocations in lymphoid cells. In present study, we identify a microRNA, miR-501, which can regulate expression RAG1 Overexpression pre-miRNA construct led generation mature miRNAs concomitant reduction expression, whereas inhibition using anti-miRs resulted its enhanced expression. direct...
Two BODIPY-biotin conjugates
Aza-BODIPY biotin-based nano-self-assembly has been designed for selective NIR turn-on fluorescence activity against cancer cells.