A5084812992- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Neurological disorders and treatments
- Neuroscience and Music Perception
- Meningioma and schwannoma management
- Multisensory perception and integration
- Functional Brain Connectivity Studies
- Neurogenesis and neuroplasticity mechanisms
- Sleep and Wakefulness Research
- RNA Research and Splicing
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Memory and Neural Computing
- Intraoperative Neuromonitoring and Anesthetic Effects
- Advanced Neuroimaging Techniques and Applications
- RNA regulation and disease
- Adrenal and Paraganglionic Tumors
- Molecular Communication and Nanonetworks
- Advanced MRI Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Trigeminal Neuralgia and Treatments
- Surgical Simulation and Training
- Electrical and Bioimpedance Tomography
Oregon Health & Science University
2020-2024
Neurological Surgery
2020-2024
Center for Neurosciences
2023-2024
Oxford University Press (United Kingdom)
2020
Electrophysiological devices are critical for mapping eloquent and diseased brain regions therapeutic neuromodulation in clinical settings extensively used research brain-machine interfaces. However, the existing experimental often limited either spatial resolution or cortical coverage. Here, we developed scalable manufacturing processes with a dense electrical connection scheme to achieve reconfigurable thin-film, multithousand-channel neurophysiological recording grids using platinum...
Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby such “binding” different components mental events into unified representations occurs is unknown. “binding-by-synchrony” theory proposes that distributed encoding areas are bound by synchronous oscillations enabling enhanced communication. However, evidence for sparse. Brief high-frequency (“ripples”) occur hippocampus cortex help...
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration their connections that drives progressive disability in demyelinating disease. However, whether chronic triggers neurodegeneration how it may do so remain unclear. We characterize two genetic mouse models inducible demyelination, one distinguished by effective remyelination other failure demyelination. While both lines feature axonal damage, mice with blocked have elevated neuronal...
OBJECTIVE Whether obesity is associated with meningioma and the impact of by gender has been debated. The primary objective this study was to investigate differences in BMI between male female patients undergoing craniotomy for compare those other intracranial tumors. secondary location progression-free survival (PFS) obese nonobese a multi-institutional cohort. METHODS National data were obtained from Surgical Quality Improvement Program (NSQIP) database. Male analyzed separately. Patients...
Intracranial electrophysiology analysis requires precise location and anatomical labeling of electrode recording contacts before a signal processing the data can be interpreted.Signal techniques are common to other modalities, such as magnetoencephalography (MEG) electroencephalography (EEG), so ideally locating intracranial electrodes would an integrated part single software package.This work covers addition localization intracranial-specific analyses MNE-Python (Gramfort et al., 2013)...
Intraoperative neuromonitoring (IONM) is a widely used practice in spine surgery for early detection and minimization of neurological injury. IONM most commonly conducted by indirectly recording motor somatosensory evoked potentials from either muscles or the scalp, which requires large-amplitude electrical stimulation provides limited spatiotemporal information. may inform inadvertent events during neurosurgery after they occur, but it does not guide safe surgical procedures when anatomy...
Modular organization is fundamental to cortical processing, but its presence human association cortex unknown. We characterized phoneme processing with 128-1024 channel micro-arrays at 50-200µm pitch on superior temporal gyrus of 7 patients. High gamma responses were highly correlated within ~1.7mm diameter modules, sharply delineated from adjacent modules distinct time-courses and phoneme-selectivity. suggest that receptive language may be organized in discrete modules.
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration their connections that drives progressive disability in demyelinating disease. However, whether chronic triggers neurodegeneration how it may do so remain unclear. We characterize two genetic mouse models inducible demyelination, one distinguished by effective remyelination other failure demyelination. While both lines feature axonal damage, mice with blocked have elevated neuronal...
Previous electrophysiological research has characterized canonical oscillatory patterns associated with movement mostly from recordings of primary sensorimotor cortex. Less work attempted to decode based on a broader array brain areas such as those sampled by stereoelectroencephalography (sEEG), especially in humans. We aimed identify and characterize different movement-related oscillations across relatively broad sampling humans if they extended beyond previously movement.
Abstract Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby such ‘binding’ different components mental events into unified representations occurs is unknown. ‘binding-bysynchrony’ theory proposes that distributed encoding areas are bound by synchronous oscillations enabling enhanced communication. However, evidence for sparse. Brief high-frequency (‘ripples’) occur hippocampus cortex,...
Electrophysiological devices are critical for mapping eloquent and diseased brain regions therapeutic neuromodulation in clinical settings extensively utilized research brain-machine interfaces. However, the existing often limited either spatial resolution or cortical coverage, even including those with thousands of channels used animal experiments. Here, we developed scalable manufacturing processes dense connectorization to achieve reconfigurable thin-film, multi-thousand channel...
Modular organization at approximately 1 mm scale could be fundamental to cortical processing, but its presence in human association cortex is unknown. Using custom-built, high-density electrode arrays placed on the surface of 7 patients undergoing awake craniotomy for tumor excision, we investigated receptive speech processing left (dominant) posterior superior temporal gyrus. Responses consonant-vowel syllables and noise-vocoded controls recorded with 1,024 channel micro-grids 200 μm pitch...
The study objective was to evaluate intraoperative experience with newly developed high-spatial-resolution microelectrode grids composed of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and those platinum nanorods (PtNRs).
Abstract Globally, traumatic brain injury (TBI) affects 69 million individuals every year. However, there are wide variations in the management of TBI across low-, middle- and high-income countries which reflects on outcomes worldwide. This study aims to provide a comprehensive global picture surgical nonsurgical TBI. The Global NeuroSurg 1 is prospective international multicentre cohort conducted self-selected registered centers. Any hospital receiving managing patients eligible participate...
Stedelin, Brittany; Cleary, Daniel MD; Paulk, Angelique; Bourhis, Andrew; Dayeh, Shadi; Tchoe, Youngbin; Halgren, Eric PhD; Raslan, Ahmed M.T Author Information
Processing auditory human speech requires both detection (early and transient) analysis (sustained). We analyzed high gamma (70-110 Hz) activity of intracranial electroencephalography waveforms acquired during an task that paired forward speech, reverse signal correlated noise. identified widespread superior temporal sites with sustained responding only to regardless order. More localized onset responded all stimulus types when presented first in a pair recurrent fashion the second select...
Bakr, Salma; Basha, Ahmed; Stedelin, Brittany; Ernst, Lia; Kellogg, Marissa; Raslan, Ahmed M.T Author Information
Nugent, Joseph G; Stedelin, Brittany; Teton, Zoe E BS; Siler, Dominic A MD, PhD; Motika, Paul; Cetas, Justin S Zonies, David; Schreiber, Martin MD; Raslan, Ahmed M.T Author Information
Abstract BACKGROUND The female predominance of meningiomas may reflect hormonal influences on meningioma development, with known presence estrogen and progesterone receptors. Progestin-associated demonstrate a shift in the mutational landscape are more frequently located at skull base. Obesity increased adipocytes increase aromatase affect male hormone synthesis, thus increases circulating estrogen. OBJECTIVE Report prevalence obesity consecutive series patients presenting interaction...
Stedelin, Brittany; Pangelinan, Kelsey; Edwards, Jared; Cheaney, Barry II BS; Raslan, Ahmed M.T; Ernst, Lia Author Information