A5067254386- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Urinary Bladder and Prostate Research
- Soft Robotics and Applications
- CCD and CMOS Imaging Sensors
- Gastrointestinal Bleeding Diagnosis and Treatment
- Platelet Disorders and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Fractures and Fixation Techniques
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Analog and Mixed-Signal Circuit Design
- Myofascial pain diagnosis and treatment
- Electrochemical Analysis and Applications
University of California, San Diego
2021-2024
BioSurfaces (United States)
2022
Tufts University
2017
Electrophysiological devices are critical for mapping eloquent and diseased brain regions therapeutic neuromodulation in clinical settings extensively used research brain-machine interfaces. However, the existing experimental often limited either spatial resolution or cortical coverage. Here, we developed scalable manufacturing processes with a dense electrical connection scheme to achieve reconfigurable thin-film, multithousand-channel neurophysiological recording grids using platinum...
Abstract Over the past decade, stereotactically placed electrodes have become gold standard for deep brain recording and stimulation a wide variety of neurological psychiatric diseases. Current electrodes, however, are limited in their spatial resolution ability to record from small populations neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable up 128 channels able at 10 cm tissue. This...
Abstract The Utah array powers cutting‐edge projects for restoration of neurological function, such as BrainGate, but the underlying electrode technology has itself advanced little in last three decades. Here, dual‐side lithographic microfabrication processes is exploited to demonstrate a 1024‐channel penetrating silicon microneedle (SiMNA) that scalable its recording capabilities and cortical coverage suitable clinical translation. SiMNA first with flexible backing affords compliancy brain...
We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes potentials from 3D tissue-like networks neurons and cardiomyocytes obtained. Individual electrical addressability is necessary for high-fidelity electrophysiological recordings. This study paves the way toward predictive, high-throughput, low-cost drug screening platforms.
Abstract Electrophysiological recording and stimulation are the gold standard for functional mapping during surgical therapeutic interventions as well capturing cellular activity in intact human brain. A critical component probing brain is interface material at electrode contact that electrochemically transduces signals to from free charge carriers measurement system. Here, we summarize state-of-the-art array systems context of translation use stimulating activity. We leverage parametric...
Functional mapping during brain surgery is applied to define areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon electrophysiologist, which can time-consuming. In addition, electrode grids are used measure activity identify boundaries of pathological versus functional regions have low resolution limited conformity surface. Here, we present development an intracranial electroencephalogram...
Intraoperative neuromonitoring (IONM) is a widely used practice in spine surgery for early detection and minimization of neurological injury. IONM most commonly conducted by indirectly recording motor somatosensory evoked potentials from either muscles or the scalp, which requires large-amplitude electrical stimulation provides limited spatiotemporal information. may inform inadvertent events during neurosurgery after they occur, but it does not guide safe surgical procedures when anatomy...
This article presents a digitally-assisted multi-channel neural recording system. The system uses 16-channel chopper-stabilized Time Division Multiple Access (TDMA) scheme to record multiplexed signals into single shared analog front end (AFE). choppers reduce the total integrated noise across modulated spectrum by 2.4 × and 4.3 in Local Field Potential (LFP) Action (AP) bands, respectively. In addition, novel impedance booster based on Sign-Sign least mean squares (LMS) adaptive filter (AF)...
Electrophysiological devices are critical for mapping eloquent and diseased brain regions therapeutic neuromodulation in clinical settings extensively utilized research brain-machine interfaces. However, the existing often limited either spatial resolution or cortical coverage, even including those with thousands of channels used animal experiments. Here, we developed scalable manufacturing processes dense connectorization to achieve reconfigurable thin-film, multi-thousand channel...
Abstract Brain surgeries are among the most delicate clinical procedures and must be performed with technologically robust advanced tools. When such surgical in functionally critical regions of brain, functional mapping is applied as a standard practice that involves direct coordinated interactions between neurosurgeon neurology electrophysiology team. However, information flow during these commonly verbal well time consuming which turn increases duration cost surgery, possibly compromising...
Microneedle Arrays In article number 2112045, Shadi A. Dayeh and co-workers have invented an advanced brain–computer interface with a flexible moldable backing penetrating microneedles, which are 10 times thinner than the human hair. The allows device to more evenly conform brain's complex curved surface uniformly distribute microneedles that pierce cortex without piercing venules record signals from nearby nerve cells across wide area of cortex.
This paper presents a smart cage platform using magnetic sensors for 3D tracking of the location and orientation magnetically marked capsule (MMC) targeted drug delivery. For this study, small permanent magnet is placed inside to be tracked. A developed eight 3-axis magnetometers that tracks source imaging (MSI) algorithm. The was estimated within 2–3 mm in XY 6 Z direction. results presented here demonstrate noninvasive system holds great promise monitoring transit any device (such as pill) marked.
Abstract Over the past decade, stereotactically placed electrodes have become gold standard for deep brain recording and stimulation a wide variety of neurological psychiatric diseases. Current electrodes, however, are limited in their spatial resolution ability to record from small populations neurons, let alone individual neurons. Here, we report on novel, reconfigurable, monolithically integrated human-grade flexible depth electrode capable up 128 channels able at 10 cm tissue. This thin,...
Intracellular access with high spatiotemporal resolution can enhance our understanding of how neurons or cardiomyocytes regulate and orchestrate network activity, this activity be affected pharmacology other interventional modalities. Nanoscale devices often employ electroporation to transiently permeate the cell membrane record intracellular potentials, which tend decrease rapidly extracellular potential amplitudes time. Here, we report innovative scalable, vertical, ultra-sharp nanowire...