In rodents, waking firing patterns replay in NREM sleep during hippocampal sharpwave ripples (HC-SWRs), correlated with neocortical graphoelements (NC-GEs). NC-GEs include theta bursts, spindles, downstates, and upstates. humans, consolidation is scalp-recorded spindles downstates/upstates, but HC-SWRs cannot be recorded noninvasively. Here we show humans of both sexes that are highly NREM, significantly more related HC-SWRs/NC-GEs for downstates or upstates than bursts N2 N3, posterior...

Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby such “binding” different components mental events into unified representations occurs is unknown. “binding-by-synchrony” theory proposes that distributed encoding areas are bound by synchronous oscillations enabling enhanced communication. However, evidence for sparse. Brief high-frequency (“ripples”) occur hippocampus cortex help...

Human anterior and posterior hippocampus (aHC, pHC) differ in connectivity behavioral correlates. Here we report physiological differences humans of both sexes. During NREM sleep, the human generates sharpwave ripples (SWRs) similar to those which rodents mark memory replay. We show that while pHC SWRs, it also approximately as many spindle (SSR: phase-locked local spindles). In contrast, SSRs are rare aHC. Like often co-occur with neocortical theta bursts (TBs), downstates (DSs), sleep...

Animal studies support the hypothesis that in slow-wave sleep, replay of waking neocortical activity under hippocampal guidance leads to memory consolidation. However, no intracranial electrophysiological evidence for exists humans. We identified consistent sequences population firing peaks across widespread cortical regions during complete periods. The occurrence these "Motifs" were compared between sleeps preceding period ("Sleep-Pre") when Motifs identified, and those following...

Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for consolidation memories in cortex during non-rapid eye movement sleep (NREM). Recently, cortical humans have been shown to enfold replay neuron cued recall. Here, using intracranial recordings from 18 patients (12 female), we show that also occur NREM humans, with similar density, oscillation frequency (∼90 Hz), duration, and amplitude waking. Ripples occurred all regions characteristics,...

The formation of flower color is closely related to anthocyanin synthesis. In this study, flowers Bletilla striata (Orchidaceae) exhibiting distinct morphs were collected and analyzed. HPLC results showed significantly higher total flavonoid contents in purple compared pink counterparts, with increases 2.20-fold (p < 0.01) 15.22-fold 0.01), respectively. Cyanidin was the predominant B. striata. Resequencing analyses highlighted SNP as primary variation associated divergence. A...

The dialogue between cortex and hippocampus is known to be crucial for sleep-dependent memory consolidation. During slow wave sleep, replay depends on oscillation (SO) spindles in the (neo)cortex sharp wave-ripples (SWRs) hippocampus. mechanisms underlying interaction of these rhythms are poorly understood. We examined cortical SO hippocampal SWRs a model hippocampo-cortico-thalamic network compared results with human intracranial recordings during sleep. observed that ripple occurrence...

Sino-Russian higher education cooperation has made significant progress in recent years, especially language and cultural exchange diversification. The the field of between two countries is reflected not only academic research joint degree programs but also integration culture. With promotion "Belt Road" initiative, diversity systematic nature have gradually increased, providing important support for enhancing influence competitiveness both global system. This paper explores mechanisms...

In humans, sleep spindles are 10- to 16-Hz oscillations lasting approximately 0.5–2 s. Spindles, along with cortical slow oscillations, may facilitate memory consolidation by enabling synaptic plasticity. Early recordings of at the scalp found anterior channels had overall slower frequency than central-posterior channels. This robust, topographical finding led dichotomizing as “slow” versus “fast,” modeled two distinct spindle generators in frontal posterior cortex. Using a large dataset...

Abstract In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) during hippocampal sharp wave ripples (HC‐SWR). humans, HC‐SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human rigorous rejection of epileptiform activity, requiring multiple oscillations and coordinated waves. We demonstrated typical SWR those rare HC recordings which lack interictal spikes (IIS) no or minimal...

Current brain-computer interface (BCI) studies demonstrate the potential to decode neural signals obtained from structured and trial-based tasks drive actuators with high performance within context of these tasks. Ideally, maximize utility, such systems will be applied a wide range behavioral settings or contexts. Thus, we explore augment ability abstract contextual states activity.To feasibility decoding, used electrocorticography (ECoG) stereo-electroencephalography (sEEG) data recorded...

Abstract Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for consolidation memories in cortex during non-rapid eye movement sleep (NREM). Recently, cortical humans have been shown to enfold replay neuron cued recall. Here, using intracranial recordings from 18 patients (12 female), we show that also occur NREM humans, with similar density, oscillation frequency (∼90 Hz), duration, and amplitude waking. Ripples occurred all regions...

Abstract Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby such ‘binding’ different components mental events into unified representations occurs is unknown. ‘binding-bysynchrony’ theory proposes that distributed encoding areas are bound by synchronous oscillations enabling enhanced communication. However, evidence for sparse. Brief high-frequency (‘ripples’) occur hippocampus cortex,...

In analyzing the neural correlates of naturalistic and unstructured behaviors, features activity that are ignored in a trial-based experimental paradigm can be more fully studied investigated. Here, we analyze from two patients using electrocorticography (ECoG) stereo-electroencephalography (sEEG) recordings, reveal multiple signal characteristics exist discriminate between behavioral states such as "engaging dialogue" "using electronics". Using high gamma amplitude an estimate neuronal...

Abstract The dialogue between cortex and hippocampus is known to be crucial for sleep dependent consolidation of long lasting memories. During slow wave memory replay depends on oscillation (SO) spindles in the (neo)cortex sharp wave-ripple complexes (SWR) hippocampus, however, mechanisms underlying interaction these rhythms are poorly understood. Here, we examined cortical SOs hippocampal SWRs a computational model hippocampo-cortico-thalamic network compared results with human intracranial...

Abstract Human anterior and posterior hippocampus (aHC, pHC) differ in connectivity behavioral correlates. Here we report physiological differences. During NREM sleep, the human generates sharpwave-ripples (SWR) similar to those which rodents mark memory replay. We show that while pHC SWR, it also about as many spindle-ripples (SSR: ripples phase-locked local spindles). In contrast, SSR are rare aHC. Like often co-occur with neocortical theta bursts (TB), downstates (DS), spindles (SS)...

Abstract In rodents, waking firing patterns replay in NREM sleep during hippocampal sharpwave-ripples (HC-SWR), correlated with neocortical graphoelements (NC-GE). NC-GE include theta-bursts, spindles, downstates and upstates. humans, consolidation is scalp-recorded spindles down-upstates, but HC-SWR cannot be recorded non-invasively. Here we show humans of both sexes that are highly NREM, significantly more related HC-SWR/NC-GE for or upstates than theta-bursts N2 N3, posterior anterior HC,...

Abstract Studies in animals have demonstrated a strong relationship between cortical and hippocampal activity, autonomic tone. However, the extent, distribution, nature of this not been investigated with intracranial recordings humans during sleep. Cortical population neuronal firing was estimated from high γ band activity (HG) 70 to 110 Hz local field potentials (LFPs) recorded 15 subjects (nine females) nonrapid eye movement (NREM) Autonomic tone heart rate variability (HRV). HG HRV were...

The driving interaction-a critical yet complex aspect of daily driving-lies at the core autonomous research. However, real-world scenarios sparsely capture rich interaction events, limiting availability comprehensive trajectory datasets for this purpose. To address challenge, we present InterHub, a dense dataset derived by mining events from extensive naturalistic records. We employ formal methods to describe and extract multi-agent exposing limitations existing solutions. Additionally,...

Abstract In rodents, pyramidal cell firing patterns from waking may be replayed in NREM sleep during hippocampal sharpwave-ripples (HC-SWR). humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenesis. Here, we characterize human rigorous rejection of epileptiform activity, requiring multiple oscillations and coordinated sharpwaves. We demonstrated typical SWR those rare HC recordings which lack interictal spikes (IIS), no or minimal seizure involvement....

Abstract In humans, sleep spindles are 10-16 Hz oscillations lasting approximately 0.5-2 s. Spindles, along with cortical slow oscillations, facilitate memory consolidation by enabling synaptic plasticity. Early recordings of at the scalp found anterior channels had overall slower frequency than central-posterior channels. This robust, topographical finding led to dichotomizing as ‘slow’ versus ‘fast’, modelled two distinct spindle generators in frontal posterior cortex. Using a large...

Intracranial electrophysiology (iEEG) studies using cognitive tasks contribute to the understanding of neural basis language. However, though iEEG is recorded continuously during clinical treatment, due patient considerations task time limited. To increase usefulness recordings for language study we provided patients with a tablet pre-loaded media filled natural language, wirelessly synchronised iEEG. This data collected and time-locked presentation particularly applicable studying combining...