A5089255444- Cardiac Arrest and Resuscitation
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Cardiac and Coronary Surgery Techniques
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Anesthesia and Neurotoxicity Research
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Infection Control and Ventilation
- Healthcare Technology and Patient Monitoring
- Heart Rate Variability and Autonomic Control
- Chromosomal and Genetic Variations
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Disaster Response and Management
- Aortic aneurysm repair treatments
- Genomics and Phylogenetic Studies
- Cardiovascular Health and Risk Factors
- SARS-CoV-2 detection and testing
- Sphingolipid Metabolism and Signaling
- Blood transfusion and management
- Endoplasmic Reticulum Stress and Disease
Northwell Health
2019-2025
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2018-2025
Feinstein Institute for Medical Research
2019-2025
North Shore University Hospital
2021-2025
Hofstra University
2019-2021
Muhlenberg College
2015-2018
Valley Hospital
2015-2017
University of Ottawa
2016
Bon Secours Heart & Vascular Institute
2016
Columbia University
2014-2015
Abstract Background Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in current knowledge, we test hypothesis that MTx can improve outcomes CA resuscitation. Methods This study consists of both vitro and vivo studies. We initially examined migration exogenous mitochondria into primary neural cell culture vitro. Exogenous extracted from...
The human brain possesses three predominate phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS), which account for approximately 35–40%, 20% of the brain’s respectively. Mitochondrial membranes are relatively diverse, containing aforementioned PC, PE, PS, as well phosphatidylinositol (PI) phosphatidic acid (PA); however, cardiolipin (CL) phosphatidylglycerol (PG) exclusively present in mitochondrial membranes. These phospholipid interactions...
Recent studies have demonstrated the superiority of bilateral internal mammary arteries (BIMAs) as conduit material for coronary artery bypass grafting (CABG) surgery. However, there is limited research on effects other graft conduits used in patients who require additional bypasses. The goal this study was to evaluate impact radial (RA) when conjunction with BIMAs.From beginning 2000 end 2013, 4370 underwent CABG three or more vessels at our institution. There were 568 and 183 received BIMA...
Increased detection of plasma lysophosphatidic acid (LPA) has been proposed as a potential diagnostic biomarker in ovarian cancer, but inconsistency exists these reports. It shown that LPA can undergo an artificial increase during sample processing and analysis, which not accounted for cancer research. The aim this study is to provide explanation about how the may have interfered with previous analysis Using established LC-MS method, we measured other lysophospholipid levels obtained from...
Bilateral internal thoracic artery (BITA) bypass provides long-term survival benefits over strategies that use single mammary arteries during coronary grafting (CABG). However, the rate of adoption this strategy remains very low. Moreover, optimal BITA configuration and cardiopulmonary still remain a matter debate. We investigated results revascularization strategy, utilising exclusively BITA-Y composite grafts using off-pump platform sequential anastomoses.From March 2000 to November 2010,...
OBJECTIVES: Utilization of bilateral internal mammary arteries (BIMAs) has been shown to improve long-term outcomes in patients undergoing coronary artery bypass grafting. To achieve complete revascularization, BIMAs may be used as either sole conduits for revascularization through a Y-graft configuration (BIMA-Y) or deployed with additional grafts conjunction BIMAs. The purpose this study was compare the two institutions that predominantly BIMA-Y BIMA plus optimal revascularization....
<ns4:p>Cardiac arrest remains a significant cause of death and disability throughout the world. However, as our understanding cardiac resuscitation physiology has developed, new technologies are fundamentally altering potential to improve survival neurologic sequela. Some advances relatively simple, requiring only alterations in current basic life support measures or integration with pre-hospital organization, whereas others, such extra-corporeal membrane oxygenation, require time resource...
Ovarian cancer remains a highly lethal disease due to its late clinical presentation and lack of reliable early biomarkers. Protein-based diagnostic markers have presented limitations in identifying ovarian cancer. We tested the potential phospholipids as by utilizing inter-related regulation phospholipids, unique property that allows use ratios between phospholipid species for quantitation. High-performance liquid chromatography mass spectrometry was used measure phospholipid,...
Abstract Background and study aims The COVID-19 pandemic has disrupted routine medical care due to uncertainty regarding the risk of viral spread. One major concern for transmission both patients providers is performing aerosol-generating procedures such as endoscopy. As such, we performed a prospective examine extent contamination present in local environment before after endoscopic on positive patients. Materials methods A total 82 samples were collected from 23 surfaces procedure area...
BACKGROUND Blood transfusions are a common and costly intervention for cardiac surgery patients. Evidence suggests that more restrictive transfusion strategy may reduce costs transfusion‐related complications without increasing perioperative morbidity mortality. STUDY DESIGN AND METHODS A transfusion‐limiting protocol was developed implemented in cardiovascular unit. Over 5‐year period, data were collected on patient characteristics, procedures, utilization of blood products, morbidity,...
Background: Health care systems in the United States are continuously expanding and contracting spaces to treat patients with coronavirus disease 2019 (COVID-19) intensive units (ICUs). As a result, hospitals must effectively decontaminate contain severe acute respiratory syndrome 2 (SARS-CoV-2) constructed deconstructed ICUs that for COVID-19. We assessed decontamination of COVID-19 ICU examined containment efficacy combined contact droplet precautions creating maintaining...