A5053721516- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Healthcare Technology and Patient Monitoring
- High Altitude and Hypoxia
- Patient Safety and Medication Errors
- Cardiovascular and Diving-Related Complications
- Cardiovascular and exercise physiology
- Mechanical Circulatory Support Devices
- Neuroscience of respiration and sleep
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Clinical Nutrition and Gastroenterology
- Intravenous Infusion Technology and Safety
- Simulation-Based Education in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Health, Medicine and Society
- Anesthesia and Sedative Agents
Feinstein Institute for Medical Research
2020-2024
Northwell Health
2020-2024
Nihon Kohden (Japan)
2014-2023
Tokyo Institute of Technology
2008
The concept that resuscitation from cardiac arrest (CA) results in a metabolic injury is broadly accepted, yet patients never receive this diagnosis. We sought to find evidence of injuries after CA by measuring O
Background Cardiac arrest (CA) can induce oxidative stress after resuscitation, which causes cellular and organ damage. We hypothesized that post-resuscitation normoxic therapy would protect organs against improve oxygen metabolism survival. tested the oxygen-sensitive reactive species from mitochondria to determine association with hyperoxia-induced stress. Methods Results Sprague-Dawley rats were subjected 10-minute asphyxia-induced CA a fraction of inspired O2 0.3 or 1.0 (normoxia versus...
Abstract Cardiac arrest (CA) and concomitant post‐CA syndrome lead to a lethal condition characterized by systemic ischemia–reperfusion injury. Oxygen (O 2 ) supply during cardiopulmonary resuscitation (CPR) is the key success in resuscitation, but sustained hyperoxia can produce toxic effects post CA. However, only few studies have investigated optimal duration dosage of O administration. Herein, we aimed determine whether high concentrations at are beneficial or harmful. After rats were...
Traditional capillary refill time (CRT) is a manual measurement that commonly used by clinicians to identify deterioration in peripheral perfusion status. Our study compared novel method of measuring using an investigational device with standardized visual CRT and tested the clinical usefulness this device, existing pulse oximetry sensor, emergency department (ED) setting.An ED attending physician quantitatively measured chronometer (standardized CRT). The sensor was attached same hand....
Abstract Background High-quality cardiopulmonary resuscitation (HQ-CPR) is of paramount importance to improve neurological outcomes cardiac arrest (CA). The purpose this study was evaluate chest compression methods by combining two theories: and thoracic pumps. Methods Male Sprague-Dawley rats were used. Three types studied. 1-side method performed vertically with 2 fingers over the sternum. 2-side horizontally fingers, bilaterally squeezing wall. 3-side combined methods. Rats underwent 10...
Abstract Using a new method for measuring the molecular ratio (R) of inhalation to exhalation, we investigated effect high fraction inspired oxygen (FIO2) on consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ) in mechanically ventilated rats. Twelve rats were equally assigned into two groups by anesthetics: intravenous midazolam/fentanyl vs. inhaled isoflurane. R, VO2, VCO2, RQ measured at FIO2 0.3 or 1.0. R error was ± 0.003. 1.0099 0.0023 with isoflurane...
To develop a system that is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (V̇o2), carbon dioxide generation (V̇co2), and respiratory quotient (RQ) validate its use in clinical settings.This was prospective, observational study conducted at suburban, quaternary care teaching hospital. Healthy volunteers patients 18 years or older who received mechanical ventilation were enrolled.Data from 3 healthy 7 analyzed this study. The interrater reliability...
Develop an automated approach to detect flash (<1.0 s) or prolonged (>2.0 capillary refill time (CRT) that correlates with clinician judgment by applying several supervised machine learning (ML) techniques pulse oximeter plethysmography data.Data was collected in the Pediatric Intensive Care Unit (ICU), Cardiac ICU, Progressive Unit, and Operating Suites a large academic children's hospital. Ninety-nine children 30 adults were enrolled testing validation cohorts, respectively. Patients had 5...
Capillary refill time(CRT) is a non-invasive method to assess tissue perfusion, routinely performed in pediatric practice. Current methods measure CRT have limitations objectivity and reproducibility. The measurement depends on clinician’s assessment. New analytic approach using pulse oximeter waveform has been developed. Hypothesis: measured by device clinicians(critical care/anesthesiologist attending physicians) were different across skin color finger thickness. Method: Children(1-12 yr)...
Capnometry is a method to measure carbon dioxide (CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) in exhaled gas and its use during polysomnography (PSG) for diagnostic of sleep apnea-hypopnea syndrome expanding. However, some problems exist using capnometer combination with other respiratory monitoring devices because capnometry requires additional sampling cannula or airway adapter attached patients. To resolve these problems, we...
Abstract Background Oxygen consumption (VO 2 ), carbon dioxide generation (VCO and respiratory quotient (RQ), which is the ratio of VO to VCO , are critical indicators human metabolism. To seek a link between patient’s metabolism pathophysiology illness, we investigated correlation these values with mortality in care patients. Methods This was prospective, observational study conducted at suburban, quaternary teaching hospital. Age 18 years or older healthy volunteers patients who underwent...
Abstract Objective: Using a system, which accuracy is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (VO 2 ), carbon dioxide generation (VCO and respiratory quotient (RQ), we aimed continuously measure these metabolic indicators compare values between post-cardiothoracic surgery critical care patients. Methods: This was prospective, observational study conducted at suburban, quaternary teaching hospital. Age 18 years or older healthy volunteers...
Using a system, which accuracy is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ), we aimed continuously measure these metabolic indicators compare values between post-cardiothoracic surgery critical care patients.This was prospective, observational study conducted at suburban, quaternary teaching hospital. Age 18 years or older patients who underwent mechanical ventilation were...
Objective: The traditional capillary refill time (CRT) assessment is a manual measurement that commonly used by clinicians to identify shock status. Given the only, it relatively subjective measurement. Our study tested an investigational CRT device, comprised of existing pulse oximeter technology paired with novel measuring algorithm, at emergency department (ED) setting determine its reliability and clinical usefulness compared traditional, assessment. Methods: Three healthcare providers...
Objective: Capillary refill time (CRT) measured at the bedside is widely promulgated as an acceptable method to identify patients in shock. However, inter-observer reliability of CRT visual assessments questionable. To investigate variability that occurs when healthcare providers (HCP) visually assess CRT, we conducted a study emergency department (ED) simultaneously while recording change patients’ fingertip color by video. Methods: Three HCPs were selected perform manual classified having...