A5069353202- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Plant Molecular Biology Research
- Wnt/β-catenin signaling in development and cancer
- Fibroblast Growth Factor Research
- Leaf Properties and Growth Measurement
- Drug-Induced Adverse Reactions
- Autoimmune and Inflammatory Disorders
- Blood disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Plant Reproductive Biology
- Skin and Cellular Biology Research
- Skin Diseases and Diabetes
The University of Tokyo
2021-2022
Nippon Medical School Hospital
2016
Abstract Background Acanthosis nigricans ( AN ) can occur as a cutaneous manifestation of genetic diseases, one which is associated with activating mutations the fibroblast growth factor receptor 3 gene FGFR ). Objective We explored familial patients and examined effectiveness glycolic acid GA peeling in improving their skin manifestations. Methods Sanger sequencing was performed for genomic DNA extracted from leucocytes family members involving . carried out two once every 2 weeks. Results...
Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible can be achieved with diffusing molecules, especially when that concerns differentiation of thin tissues. Wnt morphogen organizes cardiac development. Wnt6 patterns cardiogenic mesoderm to induce tissue, the pericardium, Xenopus. In this study, we revealed receptor, frizzled-7, expressed Wnt-dependent With combination experiments and mathematical...
Abstract Organisms have a variety of three-dimensional (3D) structures that change over time. These changes include twisting, which is 3D deformation cannot happen in two dimensions. Twisting linked to important adaptive functions organs, such as adjusting the orientation leaves and flowers plants align with environmental stimuli (e.g. light, gravity). Despite its importance, underlying mechanism for twisting remains be determined, partly because there no rigorous method quantifying plant...
Abstract Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible can be achieved with diffusing molecules, especially when differentiation of thin region. Wnt morphogen that organizes cardiac development; Wnt6 patterns the cardiogenic mesoderm to induce pericardium Xenopus . It is, however, pattern such tissue. In this study, we reveal receptor, frizzled7 , expressed Wnt-dependent manner prospective...