A5010594594- Wnt/β-catenin signaling in development and cancer
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Proteoglycans and glycosaminoglycans research
- Tissue Engineering and Regenerative Medicine
Tokyo University of the Arts
2022-2023
The University of Tokyo
2021-2023
Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible can be achieved with diffusing molecules, especially when that concerns differentiation of thin tissues. Wnt morphogen organizes cardiac development. Wnt6 patterns cardiogenic mesoderm to induce tissue, the pericardium, Xenopus. In this study, we revealed receptor, frizzled-7, expressed Wnt-dependent With combination experiments and mathematical...
Neural tissue is derived from three precursor regions: neural plate, crest, and preplacodal ectoderm. These regions are determined by morphogen-mediated signaling. Morphogen distribution generally regulated binding to an extracellular matrix component, heparan sulfate (HS) proteoglycan. HS modified many enzymes, such as N-deacetyl sulfotransferase 1 (Ndst1), which highly expressed in early development. However, functions of modifications ectodermal patterning largely unknown. In this study,...
Abstract Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible can be achieved with diffusing molecules, especially when differentiation of thin region. Wnt morphogen that organizes cardiac development; Wnt6 patterns the cardiogenic mesoderm to induce pericardium Xenopus . It is, however, pattern such tissue. In this study, we reveal receptor, frizzled7 , expressed Wnt-dependent manner prospective...