A5002318945- bioluminescence and chemiluminescence research
- Photoreceptor and optogenetics research
- Vibration Control and Rheological Fluids
- Chemical Synthesis and Analysis
- Vehicle Dynamics and Control Systems
- Lung Cancer Treatments and Mutations
- Biochemical and Molecular Research
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Cell death mechanisms and regulation
- Hydraulic and Pneumatic Systems
- Seismic Performance and Analysis
- Tardigrade Biology and Ecology
- Click Chemistry and Applications
- Melanoma and MAPK Pathways
- Phagocytosis and Immune Regulation
- Multicomponent Synthesis of Heterocycles
- RNA and protein synthesis mechanisms
- Plant and animal studies
- Vibration and Dynamic Analysis
- SARS-CoV-2 detection and testing
- Viral Infectious Diseases and Gene Expression in Insects
- Hippo pathway signaling and YAP/TAZ
- Signaling Pathways in Disease
- Cancer therapeutics and mechanisms
Czech Technical University in Prague
2022-2023
KU Leuven
2022-2023
Forma Therapeutics (United States)
2019
Scripps Research Institute
2013
Screen
2013
Pontifícia Universidade Católica do Rio Grande do Sul
2013
University of California, San Diego
2010
Kyoto University
2006
Kyoto University Institute for Chemical Research
2006
Kinases are known to regulate fundamental processes in cancer including tumor proliferation, metastasis, neovascularization, and chemoresistance. Accordingly, kinase inhibitors have been a major focus of drug development, several now approved for various indications. Typically, selected via high-throughput screening using catalytic domains at low ATP concentration, this process often yields mimetics that lack specificity and/or function poorly cells where levels high. Molecules targeting the...
There are reports of greater survival rates in nonsmall cell lung cancer (NSCLC) patients female gender. The objective this study was to evaluate the role gender NSCLC treated surgically with curative intent (stage I/II).In a retrospective cohort design, we screened 498 submitted thoracotomies at hospital Sγo Lucas, Porto Alegre, Brazil from 1990 2009. After exclusion that did not fit all inclusion criteria, analyzed 385 subjects. Survival using Kaplan-Meier method. Cox regression model used...
This article presents a control design method for simultaneous shaping of the poles and zeros linear time-invariant systems, motivated by application non-collocated vibration suppression to flexible multi-body systems. An entire vibrations at target mass given excitation frequencies can be recast into problem assigning transfer function from force mass' position. The requirement achieving sufficient damping in closed loop system combined with suppressing target, leads minimization spectral...
The problem of non-collocated vibration absorption is targeted utilizing a multiparameter delay-based controller. combined objective to achieve closed-loop stability and suppression at target location, which different from the position absorber. This can be translated into an optimization shaping poles system with delays subject zero-location constraints. solution approach involves remodelling as delay-differential algebraic equations (DDAEs) allows systematically account for in control law,...
We have developed a synthetic route for the preparation of hybrid bisubstrate small molecule based on nucleoside. A prototype compound was designed and docked into catalytic domain AdSS enzyme bridging region between magnesium center protein to nucleoside region. The synthesis involves coupling brominated peptide fragment capable complexing thiolated obtain model compound.
Abstract KRAS is the most frequently mutated oncogene with high prevalence in pancreatic, colorectal, and non-small cell lung cancers. signaling tightly regulated release of negative feedback pathways have limited clinical efficacy inhibitors downstream MAPK mutant context. Here we report discovery BI-3406, a highly potent selective, first-in-class, orally bioavailable SOS1::KRAS inhibitor that binds to catalytic domain guanine exchange factor SOS1 thereby preventing interaction KRAS-GDP. In...