Mami Chihara
A5045410775- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Cardiac tumors and thrombi
- Vestibular and auditory disorders
- Cancer Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Cardiac electrophysiology and arrhythmias
- T-cell and B-cell Immunology
- Heat shock proteins research
- Sarcoma Diagnosis and Treatment
- Pharmacological Effects and Assays
- Reproductive Biology and Fertility
- Dermatology and Skin Diseases
- Receptor Mechanisms and Signaling
- Galectins and Cancer Biology
- Inflammatory Myopathies and Dermatomyositis
- Vascular Tumors and Angiosarcomas
- Chronic Lymphocytic Leukemia Research
- Biochemical Analysis and Sensing Techniques
- Immune Cell Function and Interaction
- Blood disorders and treatments
Jikei University School of Medicine
2018-2021
Hokkaido University
2015
Akita University
2011-2013
Epidemiological studies have shown that the prevalence of adult asthma and severe is higher in women. It has also been reported female mice are more susceptible than males to development allergic airway inflammation hyperresponsiveness (AHR). The influence gender difference pathogenesis asthma, especially remodelling an animal model, studied rarely. We investigated using a long-term antigen-challenged mouse model.Following ovalbumin (OVA)/alum intraperitoneal injection, male or (BALB/c) were...
<i>Background:</i> Tissue eosinophilia is one of the hallmarks allergic diseases and Th2-type immune responses including asthma. Systemic inflammation caused by adipose tissue in obesity via production adipokines such as leptin has been attracting attention recently a contributor to exacerbation reactions. In this study, we examined whether might affect eosinophil chemotactic responses. <i>Methods:</i> Peripheral blood eosinophils were purified, effect on migration...
Signaling through coinhibitory receptors downregulates the immune response to prevent excessive activation and maintain optimal immunity tolerance. The aim of this study was examine levels soluble forms their ligands, namely, galectin-9 (the ligand T-cell immunoglobulin mucin domain 3) CD155 T cell immunoreceptor tyrosine-based inhibitory motif domain), association with clinical features in patients systemic sclerosis (SSc). serum sCD155 were examined by enzyme-linked immunosorbent assays...
Abstract The T‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT) is a co‐inhibitory receptor mainly expressed on T cells. Although TIGIT plays an important role in various autoimmune diseases, its atopic dermatitis (AD) remains unclear. In this study, we examined the expression levels of their association with clinical features patients AD. CD4 + cells, central memory effector cells regulatory was determined by flow cytometry. exhibited enhanced AD...
MRL/MpJ mice possess highly heat-shock-resistant spermatocytes (HRS) in comparison with C57BL/6 mice. This resistance depends on the MRL/MpJ-type loci at 81 cM region of Chromosome (Chr) 1 and 40 Chr 11. To evaluate functions these detail, we examined histopathological changes resulting from experimental cryptorchidism or transient scrotal heat stress (SHS) testes C57BL/6-based congenic strains (B6.MRLc1, B6.MRLc11, B6.MRLc1c11) carrying MRL/MpJ-derived responsible for HRS. Among cryptorchid...
Background Epidemiological studies have already shown that females are dominant in terms of the sex ratio adult asthma prevalence and severe asthma. It has also been reported female mice more susceptible to development allergic airway inflammation hyperresponsiveness (AHR) than males. However, there few reports on difference pathogenesis asthma, especially remodeling an animal model. In this study, we investigated formation using a long-term antigen challenged