A5101554289- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Blood Pressure and Hypertension Studies
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Orthopedic Surgery and Rehabilitation
- Chronic Lymphocytic Leukemia Research
- Shoulder Injury and Treatment
- Cytomegalovirus and herpesvirus research
- DNA Repair Mechanisms
- Infant Nutrition and Health
- Neurological Disease Mechanisms and Treatments
- Retinoids in leukemia and cellular processes
- Cardiac tumors and thrombi
- Epigenetics and DNA Methylation
Yokohama City University
2012-2024
Kanagawa Cancer Center
2016-2021
Kanagawa Prefectural Hospital Organization
2016-2021
Satou Hospital
2019
University of the Ryukyus
2019
Okinawa Prefectural Chubu Hospital
2019
Toyohashi Municipal Hospital
2018
Yokohama City University Medical Center
2015-2016
Shizuoka Red Cross Hospital
2013-2014
Chukyo University
2009
The tumor microenvironment, including tumor-infiltrating lymphocytes and myeloid-derived cells, is an important factor in the pathogenesis clinical behavior of malignant lymphoma. However, prognostic significance peripheral monocytes lymphoma remains unclear.We evaluated impact absolute lymphocyte count (ALC), monocyte (AMC), lymphocyte/monocyte ratio (LMR) 359 diffuse large B-cell (DLBCL) patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone...
Background The quick sequential organ failure assessment (qSOFA) score has recently been introduced to the emergency department (ED) and wards, it predicted a higher number of deaths among patients with sepsis compared baseline risk. However, studies about application qSOFA are limited in prehospital settings. Thus, this study aimed assess performance predicting risk mortality infection. Methods This single center, retrospective cohort was conducted Japanese tertiary care teaching hospital...
This study evaluated the efficacy of central nervous system (CNS) prophylaxis using intrathecal methotrexate (IT-MTX) in patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively studied 322 who achieved first complete remission (CR) after rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy. The CNS consisted four doses IT-MTX (15 mg) hydrocortisone (25 administered CR was achieved. Forty (12%) received (group A) 282 (88%) did not B)....
Background: Combination antihypertensive therapy with an angiotensin receptor blocker (ARB) and a calcium channel (CCB) or diuretics is common. This subanalysis investigated blood pressure (BP) variability in patients receiving ARB-based combination therapy. Methods: In prospective, randomized, open-label trial, hypertensive outpatients (≥65 years) who did not achieve their target BP ARB monotherapy switched to losartan 50 mg/hydrochlorothiazide 12.5 mg (ARB + D) plus amlodipine 5 C) for 12...
Treatment with a free radical scavenger could be new option for ischemic brain attack, however, little is known about the alteration of oxidative stress markers induced by edaravone, novel scavenger, in human attack.We investigated effects edaravone on patients attack. Twenty-one attack and 19 controls were enrolled this study. Blood samples obtained just before soon after first administration (30 mg) or ozagrel (40 mg). Intracellular reactive oxygen species neutrophils measured using...
Objectives Patient outcomes after out-of-hospital cardiac arrest (OHCA) varies at multilevel (geographical regions, emergency medical service agencies and receiving hospitals) in the USA. However, it remains unclear whether there is a variation patient OHCA between relevant units of healthcare system such as hospitals Japan. Therefore, we aimed to quantify Design Secondary analysis prospective multicentre registry. Setting The Japan Association for Acute Medicine Registry, registry,...
Abstract Pirarubicin tetrahydropyranyl adriamycin (THP‐ADR) is an analogue of doxorubicin. This agent exhibits activity against some doxorubicin‐resistant cell lines. We performed a phase II study biweekly THP‐COP [50 mg/m 2 pirarubicin, 750 cyclophosphamide, 1.4 vincristine (2.0 mg maximum) on day 1, and 100 mg/body predonisolone days 1–5] in patients with peripheral T‐cell lymphoma (PTCL). Seventeen newly diagnosed PTCL were enrolled. Histological diagnoses PTCL, not otherwise specified (...
Objective: Combination therapy with angiotensin receptor blockers (ARBs) and calcium channel or diuretics is common for hypertensive patients. This study aimed to determine which combination better elderly Methods: In this prospective, randomized, open-label trial, outpatients aged at least 65 years who had not achieved their target blood pressure (BP) standard ARB dosages were randomly assigned receive either a fixed-dose of losartan (50 mg) hydrochlorothiazide (12.5 (ARB+D; n = 72)...
Cytomegalovirus (CMV) reactivation and natural killer (NK) cell reconstitution are well-recognized immunologic events occurring after allogeneic stem transplantation (allo-SCT). We aimed to study the outcome of CMV (CMVR) NK in patients with hematologic malignancies allo-SCT. retrospectively studied 246 adult (152 men, 94 women; median age, 51 years [range, 18 69]) who underwent allo-SCT for at Kanagawa Cancer Center. CMVR was defined as initiation preemptive therapy pp65 antigenemia...
The prognosis for disease relapse after first hematopoietic cell transplantation (HCT1) is poor. Here, we present a retrospective multicenter study to evaluate the clinical outcome and prognostic factors second (HCT2). cohort in this comprised 60 patients diagnosed with acute leukemia, who underwent HCT2 due hematological HCT1. overall survival (OS) at two years, non-relapse mortality (NRM), (RM) were 30.3%, 40.9%, 28.8%, respectively. Multivariate analysis OS identified use of donor other...
"Musculoskeletal pain may be associated with imatinib withdrawal syndrome in chronic myeloid leukemia patients." Leukemia & Lymphoma, 57(2), pp. 496–497
This report examined the temporal consistency of preshot routines and similarity variability between simulated movements before after a shot. 12 male amateur golfers ages 32 to 69 years ( M = 53.4, SD 10.5) were assigned into two groups according their handicaps: skilled 4.0 handicap, 3.1) less-skilled 16.0 6.5). They performed shots mentally from points when balls came rest, then same physically again recalled mentally. For each four par-three holes, participants' performances filmed,...
Angiotensin receptor blockers (ARBs) plus calcium channel (CCBs) are a widely used combination therapy for hypertensive patients. In order to determine which was better as the next-step standard-dose of ARBs and CCBs, with high-dose CCBs or triple diuretics, authors conducted prospective, randomized, open-label trial following is treatment: diuretics. Hypertensive outpatients who did not achieve their target blood pressure (BP) usual dosages amlodipine 5 mg were randomly assigned treatment...
BACKGROUND:Acquired platythorax, or flattening of the chest with a reduction in anteroposterior (AP) diameter, is very rare and prognosis depends on degree deformity, respiratory function, any underlying disease. Drug-induced pulmonary fibrosis associated hypoplasia. A case acquired platythorax presented young man previously treated cyclophosphamide childhood. CASE REPORT:A 20-year-old began to experience cough, pain, mild exertional dyspnea. He was admitted hospital at 23 years age failure....
Objective Fludarabine plus melphalan (FM) and fludarabine busulfan (FB) are two major conditioning regimens for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods We retrospectively analyzed patients who underwent allo-HSCT after a regimen consisting of FM or FB with/without total body irradiation hematological malignancies between 2005 2014. Results There were 41 met the criteria. The median follow-up time survivors was 3 years. Thirty-two received nine regimen....