A5067789606- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Food Allergy and Anaphylaxis Research
- Pediatric Pain Management Techniques
- Psoriasis: Treatment and Pathogenesis
- Airway Management and Intubation Techniques
- Contact Dermatitis and Allergies
- Thermoregulation and physiological responses
- Gender Roles and Identity Studies
- Delphi Technique in Research
- Exercise and Physiological Responses
- Herbal Medicine Research Studies
- Gastrointestinal motility and disorders
- Transgenic Plants and Applications
- Anesthesia and Sedative Agents
- Circadian rhythm and melatonin
- Fungal Infections and Studies
- Infectious Diseases and Tuberculosis
- Advancements in Transdermal Drug Delivery
- High Altitude and Hypoxia
- Facial Rejuvenation and Surgery Techniques
Jikei University School of Medicine
1996-2023
Deleted Institution
2012
University Hospital Münster
2012
University of Shizuoka
2009
The Jikei University Hospital
2004
Tokyo Medical and Dental University
1990-1993
The most commonly used tool for self-report of pruritus intensity is the visual analogue scale (VAS). Similar tools are numerical rating (NRS) and verbal (VRS). In present study, initiated by International Forum Study Itch assessing reliability these tools, 471 randomly selected patients with chronic itch (200 males, 271 females, mean age 58.44 years) recorded their on VAS (100-mm line), NRS (0-10) VRS (four-point) scales. Re-test was analysed in a subgroup 250 after one hour. Statistical...
Pruritus in haemodialysis patients is an intractable disease and substantially impairs their quality of life. Based on the results our earlier clinical study, we hypothesized that micro-(mu) opioid system itch-inducible, whereas kappa (kappa) itch-suppressive.The efficacy safety nalfurafine hydrochloride (a novel kappa-receptor agonist) were prospectively investigated by randomly (1:1:1) administering 5 or 2.5 microg drug a placebo orally for 14 days using double-blind design 337 with itch...
Chronic pruritus is a common symptom and there an urgent need to test new anti-pruritic substances in high-quality clinical trials. However, no widely accepted standardized validated method for objectively measuring yet available. A special interest group of the International Forum Study Itch has been established assess scoring methods questionnaires use This paper presents our current recommendations. The set measures we recommend includes intensity scales, instruments assessment scratch...
<b><i>Background:</i></b> Our previous placebo-controlled, prospective, double-blind study demonstrated that a new opioid ĸ-receptor agonist, nalfurafine hydrochloride, effectively reduced treatment-resistant pruritus in 337 hemodialysis patients. Thus, we designed this to evaluate prospectively the efficacy, safety, addiction liability, and pharmacokinetics of given orally for 1 year. <b><i>Methods:</i></b> This open-label examined effects...
The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains atopic eczema (AE) clinical trials. Previous consensus meetings have agreed on preferred instruments clinician-reported signs (Eczema Area and Severity Index, EASI) patient-reported symptoms (Patient-Oriented Measure, POEM). This paper reports decisions from the HOME VII meeting.To complete AE by agreeing quality life (QoL), long-term control itch intensity.A face-to-face meeting was...
Measuring outcomes in clinical practice can aid patient care, quality improvement, and real-world evidence generation. The Harmonising Outcome Measures for Eczema (HOME) Clinical Practice initiative is developing a list of validated, feasible instruments to measure atopic eczema care. Prior work identified symptoms long-term control as the most important domains practice. Patient-Oriented Measure (POEM) Scoring Atopic Dermatitis Index (PO-SCORAD) were recommended by consensus practice, but...
Itching tends to worsen at night in patients with itchy skin diseases, such as atopic dermatitis. Unconscious scratching during sleep can exacerbate symptoms, cause disturbances, or reduce quality of life. Therefore, evaluating nocturnal behaviour is important for better patient care. However, no report exists on the specific detection overnight dermatitis using a non-wearable sensor. A novel algorithm was developed specifically detect sheet-shaped body vibrometer placed under mattress. To...
The amount of nocturnal scratching can be an indirect correlate itch in pruritic dermatoses. We have previously used infrared video camera to measure atopic dermatitis (AD). Although this is a reliable method measuring scratching, it not suitable for routine monitoring clinical use.To find simplified way itch.We tried using wrist activity monitor (ActiTrac) the measurement patients with AD. ActiTrac wristwatch-shaped device that contains piezoceramic sensor and record limb movement over...
Three clinical studies were conducted to test a newly-developed app for smartwatches, which included an algorithm measure nocturnal scratching using acceleration data. The first study in 5 patients with atopic dermatitis demonstrated high reliability of the measurement compared video monitoring (positive predictive value 90.2???6.6%, sensitivity 84.6???10.2%, correlation duration per h r?=?0.851?0.901, p?
Abstract We used an infrared video camera and tape recorder system to record analyze nocturnal scratching in seven patients with atopic dermatitis (AD) three non‐itchy healthy controls. The patterns the locations of were successfully observed. Scratching bouts lasting more than 5 sec counted/and summation duration all (total time, TST) was as index scratching. TST AD turned out be some hundreds ten thousands seconds; controls between zero a hundred seconds. measured simply reliably without...
To use a sheet-shaped body vibrometer (SBV) for measuring sleep in adult patients with atopic dermatitis (AD) of various severities and to compare the results those measured by wrist actigraphy (WA).Simultaneous measurements activity during WA SBV were performed 20 outpatients AD 5 10 days. The mean count per minute (ACT) efficiency (SE) obtained using each device. severity was evaluated scoring (SCORAD), serum thymus activation-regulated chemokine (TARC) level, total immunoglobulin E...
BACKGROUND: Difelikefalin, a peripherally specific selective agonist of kappa opioid receptors, has been approved for the treatment pruritus in hemodialysis patients United States. However, there is limited evidence postdialysis intravenous use non-U.S. populations. METHODS: In this double-blind, placebo-controlled, phase 3 trial Japan, with moderate to severe were randomly allocated 1:1 receive either placebo or 0.5 μg/kg difelikefalin three times per week intravenously 6 weeks. The primary...
Abstract Serum levels of sex hormones were measured in adult patients with atopic dermatitis (AD) and compared those sex‐ age‐matched healthy controls. In 40 male AD, serum testosterone (T) (447 ± 96 vs 593 149 ng/dl, P<0.001), free (FT) (14.6 3.2 20.0 5.1 pg/ml, P<0.001) estradiol (E 2 ) (27.2 7.2 33.2 7.9 P<0.05) significantly lower luteinizing hormone (LH) (4.57 1.6 3.11 1.2 mIU/ml, higher than There no significant differences dihydrotestosterone (DHT), dehydroepiandrosterone...
Pruritus in patients undergoing hemodialysis reduces quality of life via insomnia and depression, negatively affects prognosis. For diagnosing pruritus, selecting therapeutic strategies, determining outcomes, methods are needed for objectively quantifying the degree itchiness. In 2015, Japanese version 5-D itch scale (5D-J), originally developed USA 2010, was as a simple self-administered questionnaire; it evaluated itchiness based on five components: (1) duration itchiness, (2) (3)...
Atopic dermatitis itch may cause sleep disturbance and impair quality of life. For patients finding topical therapy difficult to continue, it is important control reduce scratching. This study developed algorithms measure nocturnal scratch, using an actigraph device worn on the back hand, assessed smartphone application feedback improve adherence with therapy. In first trial, measurements in 5 participants who wore were highly correlated by a sleep-monitoring beneath mattress. Total...
ABSTRACT Our patient was a 77‐year‐old Japanese woman, who under treatment for idiopathic thrombocytopenic purpura (ITP) and chronic renal failure. She had warm nodules cord‐like induration on her left knee that appeared similar to Bazin's erythema induratum. A chest X‐ray examination revealed miliary tuberculosis; after anti‐mycobacterial therapy, the were transformed into cold, non‐tender abscess drained. Histopathological findings showed caseation necrosis in subcutaneous tissue, however,...
A total of 185 elderly Japanese patients with mild to severe dementia were surveyed on itch, using multiple methods evaluation including self-evaluation itch conducted by as well scratching behavior and marks the body surface others. As a result, 36.8% self-evaluated that they suffering from whereas 53.5% found scratch. Of those who themselves denied presence 31.4% Dry skin was in 74.1%, severity which positively correlated rating marks. These results indicate high prevalence pruritus...