A5006536202- Alcohol Consumption and Health Effects
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Genetics and Neurodevelopmental Disorders
- Face Recognition and Perception
- Liver Disease Diagnosis and Treatment
- Alcoholism and Thiamine Deficiency
- Obsessive-Compulsive Spectrum Disorders
- Family and Disability Support Research
- Behavioral and Psychological Studies
- Signaling Pathways in Disease
- Child Development and Digital Technology
- Folate and B Vitamins Research
- Neurotransmitter Receptor Influence on Behavior
- Metabolomics and Mass Spectrometry Studies
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Visual perception and processing mechanisms
- Psychosomatic Disorders and Their Treatments
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Metabolism and Genetic Disorders
- Virology and Viral Diseases
- Diet and metabolism studies
Keio University
2015-2024
Kanazawa University
2017-2024
Osaka University
2017-2024
Nagasaki International University
2024
Advanced Telecommunications Research Institute International
2024
Nagasaki University
2024
Kurihama Medical and Addiction Center
1995-2019
National Institute of Advanced Industrial Science and Technology
2017
Keio University Hospital
2004-2016
Tokyo Medical and Dental University
1999-2012
Pruritus in haemodialysis patients is an intractable disease and substantially impairs their quality of life. Based on the results our earlier clinical study, we hypothesized that micro-(mu) opioid system itch-inducible, whereas kappa (kappa) itch-suppressive.The efficacy safety nalfurafine hydrochloride (a novel kappa-receptor agonist) were prospectively investigated by randomly (1:1:1) administering 5 or 2.5 microg drug a placebo orally for 14 days using double-blind design 337 with itch...
Cerebrospinal fluid from 70 patients with Alzheimer's disease (AD) and 96 non-AD neurological diseases as well 19 normal control subjects was surveyed by sandwich enzyme-linked immunosorbent assay to quantitate levels of the microtubule-associated protein tau in cerebrospinal fluid. The level significantly increased AD compared that subjects. Increased were found irrespective age at onset, apolipoprotein E genotype, clinical stage. Western blots proteins revealed two three tau-immunoreactive...
<b><i>Background:</i></b> Our previous placebo-controlled, prospective, double-blind study demonstrated that a new opioid ĸ-receptor agonist, nalfurafine hydrochloride, effectively reduced treatment-resistant pruritus in 337 hemodialysis patients. Thus, we designed this to evaluate prospectively the efficacy, safety, addiction liability, and pharmacokinetics of given orally for 1 year. <b><i>Methods:</i></b> This open-label examined effects...
Patients with chronic liver disease sometimes develop cholestasis, which induces severe whole-body pruritus that may disrupt daily activities and sleep. To determine the efficacy of nalfurafine hydrochloride (5 μg), is a selective κ-opioid receptor agonist, in improving pruritus, we undertook double-blind placebo-controlled study patients refractory pruritus. Nalfurafine at 2.5 μg was also used to evaluate dose-response relationship.In total, 318 subjects were randomly assigned receive...
The effects of the genotype alcohol dehydrogenase-2 (ADH2) and mitochondrial aldehyde dehydrogenase (ALDH2) on drinking behavior were investigated in a population 451 Japanese. Although ALDH2*2 allele had significant inhibitory effect consumption, hence problems, apparent association was not confirmed between ADH2 overall patterns for either males or females. However, frequency ADH2*2 significantly lower male Japanese classified as alcoholic basis Kurihama Alcoholism Screening Test than...
This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in Japanese population. The 48 bp repeat third exon of dopamine D4 receptor 153 normal female students correlated with personality feature results from version Cloninger's Temperament Character Inventory. Novelty Seeking subscale Exploratory Excitability had a significant long alleles polymorphic III sequence D4DR. Our suggest that there is an traits Excitability, regardless racial...
Job interviews are significant barriers for individuals with autism spectrum disorder because these lack good nonverbal communication skills. We developed a job interview training program using an android robot. The robot consists the following three stages: (1) tele-operating and conversing others through robot, (2) face-to-face mock (3) feedback based on exercises participants were randomly assigned to two groups: one group received combined intervention "interview guidance by teachers...
The incidence and mortality statistics for oral squamous cell carcinoma (OSCC) were 10th 12th, respectively, in human cancers diagnosed worldwide 2008. In this study, to identify novel tumor-suppressive microRNAs (TS-miRNAs) their direct targets OSCC, we performed methylation-based screening 43 miRNAs encoded by 46 miRNA genes located within 500bp downstream of 40 CpG islands genome-wide gene expression profiling combination with a prediction database analysis, 18 lines, resulting the...
Background Studies have consistently demonstrated that inactive aldehyde dehydrogenase‐2 (ALDH2), encoded by ALDH2*1/2*2 , is closely associated with alcohol‐related carcinogenesis. Recently, the contributions of alcohol (ADH2) polymorphism to alcoholism, esophageal cancer, and flushing response also been described. Methods To determine effects ALDH2 ADH2 genotypes in genetically based cancer susceptibility, lymphocyte DNA samples from 668 Japanese alcoholic men more than 40 years age (91...
In this study, 1,000 Japanese male alcoholics were consecutively screened by upper gastrointestinal endoscopy with esophageal iodine staining. Associations among cancer-detection rates, drinking and smoking habits, aldehyde dehydrogenase-2 (ALDH2) genotypes evaluated. A total of 53 patients (5.3%) had histologically confirmed cancer. Esophageal cancer was diagnosed in 36, gastric 17, oropharyngolaryngeal 9 patients: 8 the esophageal-cancer multiple-cancer patients, additional cancer(s)...
A unique isoform of the catalytic subunit calmodulin-dependent protein phosphatase (CaM-PrP) was cloned from a murine testis library. The cDNA sequence 1964 base pairs contained an open reading frame encoding 513 amino acids (Mr approximately 58,706), predicted isoelectric point which (pI 7.1) much more basic than those brain isoforms 5.6-5.8). deduced acid 77-81% identical to two other CaM-PrP genes and displayed distinct Southern blot hybridization pattern, indicating that it derived...
Recent rapid technological advances have enabled robots to fulfill a variety of human-like functions, leading researchers propose the use such technology for development and subsequent validation interventions individuals with autism spectrum disorder (ASD). Although been proposed as possible therapeutic tools, physical appearances humanoid currently used in therapy these patients are highly varied. Very little is known about how varied designs experienced by ASD. In this study, we...