A5068868519- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Sperm and Testicular Function
- Endometriosis Research and Treatment
- Cancer Risks and Factors
- Prenatal Screening and Diagnostics
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Sexual Differentiation and Disorders
- Birth, Development, and Health
- Childhood Cancer Survivors' Quality of Life
- Endometrial and Cervical Cancer Treatments
- Gestational Diabetes Research and Management
- Family Support in Illness
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Hormonal and reproductive studies
- Nutrition, Genetics, and Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Family Dynamics and Relationships
- Ectopic Pregnancy Diagnosis and Management
University of Utah
2016-2025
Palo Alto Institute
2018
University of California, San Francisco
2008-2017
Institute for Reproductive Health
2017
University of Oxford
2014
Kaiser Permanente
2009-2011
University of Michigan–Ann Arbor
2009-2011
California Institute for Regenerative Medicine
2011
Stanford University
2010-2011
Weatherford College
2011
<h3>Importance</h3> Dietary supplements marketed for male fertility commonly contain folic acid and zinc based on limited prior evidence improving semen quality. However, no large-scale trial has examined the efficacy of this therapy quality or live birth. <h3>Objective</h3> To determine effect daily supplementation <h3>Design, Setting, Participants</h3> The Folic Acid Zinc Supplementation Trial was a multicenter randomized clinical trial. Couples (n = 2370; men aged ≥18 years women 18-45...
Women with obesity and infertility are counseled to lose weight prior conception treatment improve pregnancy rates birth outcomes, although confirmatory evidence from randomized trials is lacking. We assessed whether a preconception intensive lifestyle intervention acute loss superior neutral at achieving healthy live birth.In this open-label, controlled study (FIT-PLESE), 379 women (BMI ≥ 30 kg/m2) unexplained were randomly assigned in 1:1 ratio 2 modification groups lasting 16 weeks,...
The age-specific prevalence of polycystic ovaries (PCO), as defined by the Rotterdam criteria, among normal ovulatory women, has not yet been reported. It is also uncertain whether these women differ from their peers in hormonal or metabolic profile.A total 262 Caucasian aged 25-45 yr, enrolled a community-based ovarian aging study (OVA), underwent transvaginal ultrasound assessment volume and antral follicle count (AFC) early follicular phase were categorized to they met definition PCO AFC...
What are the pain characteristics among women, with no prior endometriosis diagnosis, undergoing laparoscopy or laparotomy regardless of clinical indication? Women surgically visualized reported highest chronic/cyclic and significantly greater dyspareunia, dysmenorrhea, dyschezia compared women other gynecologic pathology (including uterine fibroids, pelvic adhesions, benign ovarian cysts, neoplasms congenital Müllerian anomalies) a normal pelvis. Prior research has shown that various...
The field of reproductive endocrinology and infertility (REI) is at a crossroads; there mismatch between demand for endocrinology, assisted technology (ART) services, availability care. This document's focus to provide data justifying the critical need increased provision fertility services in United States now into future, offer approaches rectify developing physician shortage problem, suggest framework discussion on how meet that increase demand. Society REI recommend following: 1. Our...
Nonobstructive azoospermia (NOA) and primary ovarian insufficiency (POI) have common genetics that may also predispose patients to cancer risk. We hypothesized NOA or severe oligozoospermia the risk of male cancers would be higher in families women with POI. Women POI were identified using International Classification Disease codes electronic medical records (1995-2021) from 2 major healthcare systems Utah reviewed for accuracy. Using genealogy information Population Database, (n = 392)...
Objective: To assess pregnancy outcomes following non-surgical tubal occlusion using the FemBloc® system in a population of women seeking permanent contraception. Methods: Three prospective, multi-center clinical trials (Clinicaltrials.gov NCT03067272, NCT03433911, and NCT04273594) females aged 21-45 years desiring contraception, who underwent non-surgical, in-office procedure with FemBloc system, conducted collectively at twenty-five academic private medical centers United States. An...
What thresholds for total sperm count, concentration, progressive motility, and motile count (TPMC) are associated with earlier time-to-conception in couples undergoing fertility evaluation?Values well above the World Health Organization (WHO) references values up to 100 million TPMC were consistently higher conception rates.Although individual semen parameters generally not able distinguish between fertile infertile men, they can provide clinically useful information on time-to-pregnancy...
Objective To determine agreement on endometriosis diagnosis between real‐time laparoscopy and subsequent expert review of digital images, operative reports, magnetic resonance imaging ( MRI ), histopathology, viewed sequentially. Design Inter‐rater study. Setting Five urban surgical centres. Population Women, aged 18–44 years, who underwent a regardless clinical indication. A random sample 105 women with 43 without postoperative was obtained from the ENDO Methods Laparoscopies were...
Complex diseases have multifactorial etiologies making actionable diagnostic biomarkers difficult to identify. Diagnostic research must expand beyond single or a handful of genetic epigenetic targets for complex disease and explore broader system biological pathways. With the objective develop tool designed analyze comprehensive network profiles in diseases, we used publicly available DNA methylation data from over 2,400 samples representing 20 cell types various diseases. This tool, rather...
In Brief OBJECTIVE: To estimate the interrater and intrarater reliability of endometriosis diagnosis severity disease among gynecologic surgeons viewing operative digital images. METHODS: The study population comprised a random sample (n=148 [36%]) women who participated in Endometriosis: Natural History, Diagnosis Outcomes study. Four academic expert four local, specialized reviewed images, diagnosed presence or absence for each woman, rated using revised American Society Reproductive...
Abstract Context DNA damage/repair gene variants are associated with both primary ovarian insufficiency (POI) and cancer risk. Objective We hypothesized that a subset of women POI family members would have increased risk for cancer. Design Case-control population-based study using records from 1995 to 2022. Setting Two major Utah academic health care systems serving 85% the state. Subjects Women (n = 613) were identified International Classification Diseases codes reviewed accuracy....